Chiara Noli, DVM, DipECVDDr. Chiara Noli graduated in veterinary medicine from the University of Milan, Italy, in 1990. After a residency at the University of Utrecht, Holland, she obtained the European Diploma in Veterinary Dermatology in 1996. Since then she works as referral dermatologist and dermatopathologist in Northen Italy. Dr. Noli is Past President and Founder Member of the Italian Society of Veterinary Dermatology, Past President of the European Society of Veterinary Dermatology and has been Board Member of the International Society of Veterinary Dermatopathology and of the World Association for Veterinary Dermatology. Dr. Noli lectures extensively in national and international meetings, is author of more than 100 articles in Italian and international journals, of nine book chapters and of three veterinary dermatology textbooks.Aiden Foster PhD, DipACVD, MRCVSAiden Foster worked for 20 years dealing with companion animal dermatology cases in referral and first opinion practices. He trained in veterinary dermatology at the College of Veterinary Medicine, University of Wisconsin, USA and taught veterinary dermatology at the University of Bristol veterinary school. He has been the editor of the BSAVA Manual of Small Animal Dermatology 2nd edition and was an editor of the proceedings of the 5th World Congress of Veterinary Dermatology published as Advances in Veterinary Dermatology volume 5. He is a past president of the European Society of Veterinary Dermatology and has been editor-in-chief of the Wiley-Blackwell journal Veterinary Dermatology since 2006. He works for the Animal Health and Veterinary Laboratories Agency which deals with diseases of livestock. Wayne Rosenkrantz DVM, DipACVDWayne Rosenkrantz graduated from the University of California Davis in 1982. He obtained Diplomate status with the American College of Veterinary Dermatology (ACVD) in 1986. Dr. Rosenkrantz is a co-owner of all of the Animal Dermatology Clinics in the United States, and continues to actively see cases. He is a past-president of the American College of Veterinary Dermatology (ACVD) executive board and has been on past and current organizing committees for the World Congress of Veterinary Dermatology (WCVD) and a current member of the World Association for Veterinary Dermatology (WAVD). He has served on the examination committees for the ACVD as well as the Australian Board examinations. Dr. Rosenkrantz lectures and teaches extensively, and has published numerous articles and book chapters on small animal and equine dermatology. He is very active in clinical drug trials, research studies and consults with several dermatological therapeutic companies. He also received the ACVD Award for Excellence for outstanding contributions in veterinary dermatology in 2007.

“This is an excellent update on the new discoveries in the field of immunology that have increased the understanding of the pathogenesis of allergic diseases.”  (Doody’s, 16 January 2015)“These features make this a useful reference for veterinarians with an interest in veterinary allergy.”  (Journal of the American Veterinary Medical Association, 15 September 2014)“I enjoyed this book, learned and was reminded of a lot, and I recommend it as essential reading for all veterinary dermatologists and residents. The book is good value and a good choice for practices with a library. It is available in print and electronically.”  (Veterinary Record, 29 November 2014)“A must for anyone wishing to understand and manage accordingly those itchy, diarrhoeic or suffocating animals.”  (Vets Today, 1 August 2014)“In this context, one sees the importance of books of this nature. As is the case with other specialized titles in veterinary medicine, I hope that Veterinary Allergy has come to stay and we will have successive revised, expanded and updated editions, helping to keep us informed and to manage our allergic patients properly.”(Veterinary Dermatology, 5 July 2014)“From clinical presentation and treatment to allergic diseases, science and references for specialists and researchers, and chapters written by experts, this provides a powerful and highly recommended veterinary exploration that any clinician or vet student must have in their reference collections.”  (Midwest Book Review, 1 June 2014)

• Acknowledgments viiiContributors ixForeword xiiiRichard E.W. HalliwellIntroduction: the immunological basis of allergic diseases xvMichael J. DayPart 1 – Canine Allergy (Editor: Chiara Noli) 1Section 1 – Canine Atopic Dermatitis 31 Introduction: canine atopic dermatitis as an evolving, multifactorial disease 5Douglas J. DeBoer2 Canine immunoglobulin E 8Bruce Hammerberg3 The aberrant immune system in atopic dermatitis 16Rosanna Marsella4 Allergens and environmental influence 24Pascal Prélaud5 The genetics of canine atopic dermatitis 32Tim Nuttall6 Skin barrier and its role in the pathophysiology of atopic dermatitis 42Koji Nishifuji7 The role of bacterial agents in the pathogenesis of canine atopic dermatitis 51David H. Lloyd8 The role of fungal agents in atopic dermatitis 58Ross Bond 9 Clinical signs of canine atopic dermatitis 65Claude Favrot10 Diagnosis of canine atopic dermatitis 70Craig E. Griffin11 Allergen avoidance 78Daniel O. Morris12 Allergen-specific immunotherapy 85Ralf S. Mueller13 Guidelines for symptomatic medical treatment of canine atopic dermatitis 90Douglas J. DeBoer 14 Non-conventional treatments 96Ralf S. MuellerSection 2 – Food Hypersensitivity 10115 The pathogenesis of food allergy 103Hilary A. Jackson16 Cutaneous manifestations of food hypersensitivity 108Didier N. Carlotti17 Adverse reactions to food: a gastroenterologist’s perspective 115Paola Gianella18 Diagnostic workup of food hypersensitivity 119Edmund J. Rosser Jr19 Long-term management of food hypersensitivity in the dog 124Nick J. CaveSection 3 – Flea Bite Allergy 13320 Flea biology and ecology 135Marie-Christine Cadiergues 21 The pathogenesis of flea bite allergy in dogs 140Richard E.W. Halliwell22 Clinical signs of flea allergy dermatitis in dogs 145Emmanuel Bensignor23 Diagnostic investigation of canine flea bite allergy 149Dawn Logas24 Implementing an effective flea control programme 152Michael W. Dryden25 Symptomatic relief for canine flea bite hypersensitivity 158Dawn LogasSection 4 – Complicating Infections in Allergic Dogs 16126 Complicating microbial skin infections in allergic dogs 163Anette Loeffler27 Otitis in the allergic dog 175James O. NoxonSection 5 – Other Allergic Diseases in Dogs 18328 Contact allergy 185Rosanna Marsella 29 Venomous insect hypersensitivity 191Mona J. Boord30 Canine urticaria and angioedema 195Peter HillPart 2 – Feline Allergy (Editor: Aiden Foster) 201Section 1 – Cutaneous Allergy in Cats 20331 Pathogenesis—immunopathogenesis 205Petra J. Roosje32 Clinical presentations and specificity of feline manifestations of cutaneous allergies 211Claude Favrot 33 Complications of cutaneous skin allergies (skin infections) 217Laura Ordeix34 Diagnostic investigation of the allergic feline 223William E. Oldenhoff and Karen A. Moriello35 Symptomatic treatments 228Alison B. Diesel36 Allergen-specific immunotherapy 234Alison B. DieselSection 2 – Feline Asthma 23737 Feline asthma 239Carol R. ReineroSection 3 – Flea Bite Allergy 24738 Pathogenesis 249Ross Bond39 Clinical presentations 252Dawn Logas40 Diagnostic workup 255Dawn Logas41 Therapy 259Marie-Christine CadierguesSection 4 – Mosquito Bite Allergy 26542 Mosquito bite 267Masahiko Nagata Part 3 – Equine Allergy (Editor: Wayne Rosenkrantz) 271Section 1 – Culicoides Hypersensitivity and Other Insect Allergies 27343 Pathogenesis and epidemiology of Culicoides hypersensitivity 275Bettina Wagner44 Equine immunoglobulin E 279Eliane Marti and Eman Hamza 45 Clinical manifestations of Culicoides hypersensitivity 287Janet D. Littlewood46 Culicoides hypersensitivity: diagnosis 291Kerstin Bergvall47 Culicoides hypersensitivity: therapy 297Anthony A. Yu48 Other biting insect allergies 307Gwendolen LorchSection 2 – Atopic Disease in Horses—Atopic Dermatitis and Food Hypersensitivity 32749 Equine atopic dermatitis: pathogenesis 329Valerie A. Fadok50 Clinical aspects of equine atopic disease 334Wayne Rosenkrantz and Stephen White51 Equine urticaria 338Valerie A. Fadok52 Equine headshaking syndrome 344Harold C. Schott II and Annette D. Petersen53 Diagnostic workup of equine atopic disease 353Wayne Rosenkrantz and Stephen White54 Equine atopic disease symptomatic therapy and allergen-specific immunotherapy 360Wayne Rosenkrantz and Stephen WhiteSection 3 – Recurrent Airway Obstruction and Inflammatory Airway Disease 37155 Recurrent airway obstruction and inflammatory airway disease 373Vinzenz GerberSection 4 – Contact and Other Allergic Diseases 38556 Equine allergic contact dermatitis 387Chris Reeder and Joya GriffinPart 4 – Allergy in Other Domestic Species (Editor: Aiden Foster) 39557 Immunopathogenesis of allergic skin disease in livestock 397Adri van den Broek58 Psoroptes ovis 402Adri van den Broek and Stewart T.G. Burgess59 Allergic diseases of livestock species 411Aiden P. Foster60 Allergies in birds 422Claudia S. Nett-Mettler61 Allergic diseases in other pets (rodents, rabbits, and ferrets) 428Ian SayersIndex 433

Chiara Noli, DVM, DipECVDDr. Chiara Noli graduated in veterinary medicine from the University of Milan, Italy, in 1990. After a residency at the University of Utrecht, Holland, she obtained the European Diploma in Veterinary Dermatology in 1996. Since then she works as referral dermatologist and dermatopathologist in Northen Italy. Dr. Noli is Past President and Founder Member of the Italian Society of Veterinary Dermatology, Past President of the European Society of Veterinary Dermatology and has been Board Member of the International Society of Veterinary Dermatopathology and of the World Association for Veterinary Dermatology. Dr. Noli lectures extensively in national and international meetings, is author of more than 100 articles in Italian and international journals, of nine book chapters and of three veterinary dermatology textbooks.Aiden Foster PhD, DipACVD, MRCVSAiden Foster worked for 20 years dealing with companion animal dermatology cases in referral and first opinion practices. He trained in veterinary dermatology at the College of Veterinary Medicine, University of Wisconsin, USA and taught veterinary dermatology at the University of Bristol veterinary school. He has been the editor of the BSAVA Manual of Small Animal Dermatology 2nd edition and was an editor of the proceedings of the 5th World Congress of Veterinary Dermatology published as Advances in Veterinary Dermatology volume 5. He is a past president of the European Society of Veterinary Dermatology and has been editor-in-chief of the Wiley-Blackwell journal Veterinary Dermatology since 2006. He works for the Animal Health and Veterinary Laboratories Agency which deals with diseases of livestock. Wayne Rosenkrantz DVM, DipACVDWayne Rosenkrantz graduated from the University of California Davis in 1982. He obtained Diplomate status with the American College of Veterinary Dermatology (ACVD) in 1986. Dr. Rosenkrantz is a co-owner of all of the Animal Dermatology Clinics in the United States, and continues to actively see cases. He is a past-president of the American College of Veterinary Dermatology (ACVD) executive board and has been on past and current organizing committees for the World Congress of Veterinary Dermatology (WCVD) and a current member of the World Association for Veterinary Dermatology (WAVD). He has served on the examination committees for the ACVD as well as the Australian Board examinations. Dr. Rosenkrantz lectures and teaches extensively, and has published numerous articles and book chapters on small animal and equine dermatology. He is very active in clinical drug trials, research studies and consults with several dermatological therapeutic companies. He also received the ACVD Award for Excellence for outstanding contributions in veterinary dermatology in 2007.

“This is an excellent update on the new discoveries in the field of immunology that have increased the understanding of the pathogenesis of allergic diseases.”  (Doody’s, 16 January 2015)“These features make this a useful reference for veterinarians with an interest in veterinary allergy.”  (Journal of the American Veterinary Medical Association, 15 September 2014)“I enjoyed this book, learned and was reminded of a lot, and I recommend it as essential reading for all veterinary dermatologists and residents. The book is good value and a good choice for practices with a library. It is available in print and electronically.”  (Veterinary Record, 29 November 2014)“A must for anyone wishing to understand and manage accordingly those itchy, diarrhoeic or suffocating animals.”  (Vets Today, 1 August 2014)“In this context, one sees the importance of books of this nature. As is the case with other specialized titles in veterinary medicine, I hope that Veterinary Allergy has come to stay and we will have successive revised, expanded and updated editions, helping to keep us informed and to manage our allergic patients properly.”(Veterinary Dermatology, 5 July 2014)“From clinical presentation and treatment to allergic diseases, science and references for specialists and researchers, and chapters written by experts, this provides a powerful and highly recommended veterinary exploration that any clinician or vet student must have in their reference collections.”  (Midwest Book Review, 1 June 2014)

• Acknowledgments viiiContributors ixForeword xiiiRichard E.W. HalliwellIntroduction: the immunological basis of allergic diseases xvMichael J. DayPart 1 – Canine Allergy (Editor: Chiara Noli) 1Section 1 – Canine Atopic Dermatitis 31 Introduction: canine atopic dermatitis as an evolving, multifactorial disease 5Douglas J. DeBoer2 Canine immunoglobulin E 8Bruce Hammerberg3 The aberrant immune system in atopic dermatitis 16Rosanna Marsella4 Allergens and environmental influence 24Pascal Prélaud5 The genetics of canine atopic dermatitis 32Tim Nuttall6 Skin barrier and its role in the pathophysiology of atopic dermatitis 42Koji Nishifuji7 The role of bacterial agents in the pathogenesis of canine atopic dermatitis 51David H. Lloyd8 The role of fungal agents in atopic dermatitis 58Ross Bond 9 Clinical signs of canine atopic dermatitis 65Claude Favrot10 Diagnosis of canine atopic dermatitis 70Craig E. Griffin11 Allergen avoidance 78Daniel O. Morris12 Allergen-specific immunotherapy 85Ralf S. Mueller13 Guidelines for symptomatic medical treatment of canine atopic dermatitis 90Douglas J. DeBoer 14 Non-conventional treatments 96Ralf S. MuellerSection 2 – Food Hypersensitivity 10115 The pathogenesis of food allergy 103Hilary A. Jackson16 Cutaneous manifestations of food hypersensitivity 108Didier N. Carlotti17 Adverse reactions to food: a gastroenterologist’s perspective 115Paola Gianella18 Diagnostic workup of food hypersensitivity 119Edmund J. Rosser Jr19 Long-term management of food hypersensitivity in the dog 124Nick J. CaveSection 3 – Flea Bite Allergy 13320 Flea biology and ecology 135Marie-Christine Cadiergues 21 The pathogenesis of flea bite allergy in dogs 140Richard E.W. Halliwell22 Clinical signs of flea allergy dermatitis in dogs 145Emmanuel Bensignor23 Diagnostic investigation of canine flea bite allergy 149Dawn Logas24 Implementing an effective flea control programme 152Michael W. Dryden25 Symptomatic relief for canine flea bite hypersensitivity 158Dawn LogasSection 4 – Complicating Infections in Allergic Dogs 16126 Complicating microbial skin infections in allergic dogs 163Anette Loeffler27 Otitis in the allergic dog 175James O. NoxonSection 5 – Other Allergic Diseases in Dogs 18328 Contact allergy 185Rosanna Marsella 29 Venomous insect hypersensitivity 191Mona J. Boord30 Canine urticaria and angioedema 195Peter HillPart 2 – Feline Allergy (Editor: Aiden Foster) 201Section 1 – Cutaneous Allergy in Cats 20331 Pathogenesis—immunopathogenesis 205Petra J. Roosje32 Clinical presentations and specificity of feline manifestations of cutaneous allergies 211Claude Favrot 33 Complications of cutaneous skin allergies (skin infections) 217Laura Ordeix34 Diagnostic investigation of the allergic feline 223William E. Oldenhoff and Karen A. Moriello35 Symptomatic treatments 228Alison B. Diesel36 Allergen-specific immunotherapy 234Alison B. DieselSection 2 – Feline Asthma 23737 Feline asthma 239Carol R. ReineroSection 3 – Flea Bite Allergy 24738 Pathogenesis 249Ross Bond39 Clinical presentations 252Dawn Logas40 Diagnostic workup 255Dawn Logas41 Therapy 259Marie-Christine CadierguesSection 4 – Mosquito Bite Allergy 26542 Mosquito bite 267Masahiko Nagata Part 3 – Equine Allergy (Editor: Wayne Rosenkrantz) 271Section 1 – Culicoides Hypersensitivity and Other Insect Allergies 27343 Pathogenesis and epidemiology of Culicoides hypersensitivity 275Bettina Wagner44 Equine immunoglobulin E 279Eliane Marti and Eman Hamza 45 Clinical manifestations of Culicoides hypersensitivity 287Janet D. Littlewood46 Culicoides hypersensitivity: diagnosis 291Kerstin Bergvall47 Culicoides hypersensitivity: therapy 297Anthony A. Yu48 Other biting insect allergies 307Gwendolen LorchSection 2 – Atopic Disease in Horses—Atopic Dermatitis and Food Hypersensitivity 32749 Equine atopic dermatitis: pathogenesis 329Valerie A. Fadok50 Clinical aspects of equine atopic disease 334Wayne Rosenkrantz and Stephen White51 Equine urticaria 338Valerie A. Fadok52 Equine headshaking syndrome 344Harold C. Schott II and Annette D. Petersen53 Diagnostic workup of equine atopic disease 353Wayne Rosenkrantz and Stephen White54 Equine atopic disease symptomatic therapy and allergen-specific immunotherapy 360Wayne Rosenkrantz and Stephen WhiteSection 3 – Recurrent Airway Obstruction and Inflammatory Airway Disease 37155 Recurrent airway obstruction and inflammatory airway disease 373Vinzenz GerberSection 4 – Contact and Other Allergic Diseases 38556 Equine allergic contact dermatitis 387Chris Reeder and Joya GriffinPart 4 – Allergy in Other Domestic Species (Editor: Aiden Foster) 39557 Immunopathogenesis of allergic skin disease in livestock 397Adri van den Broek58 Psoroptes ovis 402Adri van den Broek and Stewart T.G. Burgess59 Allergic diseases of livestock species 411Aiden P. Foster60 Allergies in birds 422Claudia S. Nett-Mettler61 Allergic diseases in other pets (rodents, rabbits, and ferrets) 428Ian SayersIndex 433