Viral Hepatitis

Arie Zuckerman is chair of the Hepatitis B Foundation UK. He was the Director of?WHO Collaborating Centre for Reference and Research on Viral Hepatitis from 1974-1989 and 1990-2006. He was also?Principal and Dean of the Royal Free and University College Medical School and Principal and Dean of the Royal Free Hospital School of Medicine. Howard Thomas?is Vice President of British Liver Trust, 1993-present and Hepatitis B Foundation — Trustee, 2005-present. He was also President of British Association for the Study of the Liver 1996-1998. Anna Lok is a Professor of Internal Medicine and Director of Clinical Hepatology at the University of Michigan Medical Center. Her contributions include:?hepatitis B's?role in infection, treatment of hepatitis-induced diseases, development?of?cost-effective methods for preventing recurrent hep B infection following liver transplantation, and long-term effects of interferon treatment in patients with hep C. Stephen Locarnini's research group is composed of: molecular diagnostics, new drug targets in HBV and molecular pathogenesis. Stephen is also the Director of the World Health Organisation (WHO) Collaborating Centre for Virus Reference and Research at the VIDRL.

• List of Contributors viiPreface xiiSection I: Introduction to Liver Biology1 Liver regeneration and fibrosis 3Stuart J. Forbes and Malcolm R. Alison2 Hepatic immunology 13Gyongyi Szabo and Johanna BruneauSection II: Hepatitis A Virus3 Structure, molecular virology, natural history, and experimental models 29Gerardo G. Kaplan, Krishnamurthy Konduru, Mohanraj Manangeeswaran, Jerome Jacques, Nadia Amharref, and Siham Nakamura4 Epidemiology and prevention 43Benjamin Cowie and Stephen A. LocarniniSection III: Hepatitis B Virus and OtherHepadnaviridae5 Structure and molecular virology 65Souphalone Luangsay and Fabien Zoulim6 Epidemiology and prevention 81Philip R. Spradling, Dale J. Hu, and Brian J. McMahon7 Other Hepadnaviridae (Avihepadnaviridae (DHBV) and Orthohepadnaviridae (WHV)) 96Stephen A. Locarnini and Michael Roggendorf8 Molecular variants of hepatitis B surface antigen (HBsAg) 107Seyed Mohammad Jazayeri, Seyed Moayed Alavian, Payam Dindoost, Howard C. Thomas, and Peter Karayiannis9 Molecular variants of the precore, core, and core promoter regions of hepatitis B virus, and theirclinical significance 127Peter Karayiannis, William F. Carman, and Howard C. Thomas10 Natural history of chronic hepatitis B virus infection 143Yun-Fan Liaw11 Extrahepatic manifestations of hepatitis B infection 154Christian Trépo, Majid Amiri, and Loïc Guillevin12 Hepatitis B and hepatocellular carcinoma 163Marie Annick Buendia and Pierre Tiollais13 Murine models and human studies of pathogenesis of chronic hepatitis B 176Juandy Jo, Anthony Tanoto Tan, and Antonio Bertoletti14 Treatment of hepatitis B 188Hellan K. Kwon and Anna S.F. Lok15 Liver transplantation for chronic hepatitis B and C 203Ed GaneSection IV: Hepatitis C Virus16 Structure and molecular virology 221Michael J. McGarvey and Michael Houghton17 Epidemiology and prevention 246Josep Quer and Juan I. Esteban Mur18 The immune response to HCV in acute and chronic infection 266Robert Thimme and Salim I. Khakoo19 Animal models of hepatitis C virus infection 280Patrizia Farci and Jens Bukh20 Extrahepatic manifestations of hepatitis C virus infection 295Benjamin Maasoumy, Michael P. Manns, and Markus Cornberg21 Central nervous system complications of hepatitis c virus infection 310Daniel M. Forton, Simon Taylor-Robinson, Markus Gess, and Howard C. Thomas22 In vitro replication models 325Volker Lohmann, Sandra Bühler, and Ralf Bartenschlager23 Natural history of chronic HCV infection and non-invasive assessment of hepatic fibrosis 341Laurent Castera24 Hepatitis C and hepatocellular carcinoma 353Hubert E. Blum25 Treatment of hepatitis C 362Christoph Welsch and Stefan Zeuzem26 Development of anti-HCV drugs 377Esperance Schaefer and Raymond T. ChungSection V: Hepatitis D Virus27 Structure and molecular virology 395Francesco Negro28 Epidemiology and natural history 403Heiner Wedemeyer, Svenja Hardtke, and Michael P. Manns29 Treatment of hepatitis D 410Alessia Ciancio and Mario RizzettoSection VI: Hepatitis E Virus30 Structure and molecular virology 419Xiang-Jin Meng31 Epidemiology, experimental models, and prevention: zoonotic aspects of hepatitis E 431Subrat Kumar Panda and Satya Pavan Kumar Varma32 Clinical and pathological features, and diagnosis 442Cyril Sieberhagen and Matthew E. CrampSection VII: Clinical Aspects of Viral Liver Disease33 Clinical and diagnostic aspects of viral hepatitis 453Cui Li Lin, Chelsea Q. Xu, and Jack R. Wands34 Treatment of acute hepatitis, severe acute hepatitis, and acute liver failure 468Hans L. Tillmann and Alastair D. Smith35 Hepatitis and hemophilia 486Mike Makris and Geoffrey Dusheiko36 Hepatitis in persons infected with HIV 494Janice Main and Brendan McCarron37 Migration, hepatitis B, and hepatitis C 506Manuel Carballo, Rowan Cody, Megan Kelly and Angelos Hatzakis38 Occupational aspects of hepatitis 515William L. Irving and Fortune Ncube39 Neonatal and pediatric infection 529Deirdre A. Kelly and C.Y. William Tong40 Management of hepatocellular carcinoma 544Massimo Iavarone and Massimo Colombo41 Application of molecular biology to the diagnosis of viral hepatitis 552Stéphane Chevaliez, Christophe Rodriguez, and Jean-Michel Pawlotsky42 Disinfection and sterilization 564Martin S. Favero and Walter W. Bond43 Evolution of hepatitis viruses 575Peter Simmonds and Donald B. SmithIndex 587