Lawrence M. Samkoff, MD, Associate Professor of Neurology at the School of Medicine and Dentistry, University of Rochester Medical Center,  Rochester, NY, USA Andrew D. Goodman, MD, Professor of Neurology, Chief of the Neuroimmunology Unit, and Director of the Multiple Sclerosis Center at the School of Medicine and Dentistry, University of Rochester Medical Center , Rochester, NY, USA

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• Contributors viiSeries Foreword xPreface xichapter 1 1EtiologySonya U. Steele and Ellen M. Mowrychapter 2 10Immunopathogenesis of Multiple SclerosisAnne H. Cross and Laura Picciochapter 3 18Diagnostic ProcessDalia Rotstein and Paul O’Connorchapter 4 29MRI in Diagnosis and Disease MonitoringMaría I. Gaitán and Daniel S. Reichchapter 5 45Relapsing MS: Disease Staging and Therapeutic AlgorithmsMohsen Khoshnam and Mark Freedmanchapter 6 57 Progressive MS Treatment AlgorithmsMegan H. Hyland and Jeffrey A. Cohenchapter 7 67Sex-Determined Issues in Multiple SclerosisCallene Momtazee and Barbara Giesserchapter 8 77Pediatric Multiple SclerosisRobert Thompson Stone and Brenda Banwellchapter 9 91Complementary and Alternative Medicine: Risks and BenefitsAllen C. Bowlingchapter 10 102Symptomatic Management of MSJessica Robb, Lawrence M. Samkoff, and Andrew D. Goodmanchapter 11 114Invisible Symptoms of MS: Fatigue, Depression, and CognitionLeigh E. Charvet, Benzi Kluzer, and Lauren B. Kruppchapter 12 122RehabilitationNesanet S. Mitiku, Alexius E. G. Sandoval, and George H. Kraftchapter 13 134Psychosocial Adaptation to Multiple SclerosisDavid J. Rintellchapter 14 144Transverse Myelitis and Acute Disseminated EncephalomyelitisBenjamin M. Greenbergchapter 15 153Neuromyelitis OpticaMarcelo Matiello and Brian G. Weinshenkerchapter 16 163NeurosarcoidosisThomas F. Scottchapter 17 169Lyme NeuroborreliosisErica Patrick and Eric Logigianchapter 18 178Neuro-Behçet SyndromeAksel Siva and Sabahattin SaipIndex 191

Lawrence M. Samkoff, MD, Associate Professor of Neurology at the School of Medicine and Dentistry, University of Rochester Medical Center,  Rochester, NY, USA Andrew D. Goodman, MD, Professor of Neurology, Chief of the Neuroimmunology Unit, and Director of the Multiple Sclerosis Center at the School of Medicine and Dentistry, University of Rochester Medical Center , Rochester, NY, USA

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• Contributors viiSeries Foreword xPreface xichapter 1 1EtiologySonya U. Steele and Ellen M. Mowrychapter 2 10Immunopathogenesis of Multiple SclerosisAnne H. Cross and Laura Picciochapter 3 18Diagnostic ProcessDalia Rotstein and Paul O’Connorchapter 4 29MRI in Diagnosis and Disease MonitoringMaría I. Gaitán and Daniel S. Reichchapter 5 45Relapsing MS: Disease Staging and Therapeutic AlgorithmsMohsen Khoshnam and Mark Freedmanchapter 6 57 Progressive MS Treatment AlgorithmsMegan H. Hyland and Jeffrey A. Cohenchapter 7 67Sex-Determined Issues in Multiple SclerosisCallene Momtazee and Barbara Giesserchapter 8 77Pediatric Multiple SclerosisRobert Thompson Stone and Brenda Banwellchapter 9 91Complementary and Alternative Medicine: Risks and BenefitsAllen C. Bowlingchapter 10 102Symptomatic Management of MSJessica Robb, Lawrence M. Samkoff, and Andrew D. Goodmanchapter 11 114Invisible Symptoms of MS: Fatigue, Depression, and CognitionLeigh E. Charvet, Benzi Kluzer, and Lauren B. Kruppchapter 12 122RehabilitationNesanet S. Mitiku, Alexius E. G. Sandoval, and George H. Kraftchapter 13 134Psychosocial Adaptation to Multiple SclerosisDavid J. Rintellchapter 14 144Transverse Myelitis and Acute Disseminated EncephalomyelitisBenjamin M. Greenbergchapter 15 153Neuromyelitis OpticaMarcelo Matiello and Brian G. Weinshenkerchapter 16 163NeurosarcoidosisThomas F. Scottchapter 17 169Lyme NeuroborreliosisErica Patrick and Eric Logigianchapter 18 178Neuro-Behçet SyndromeAksel Siva and Sabahattin SaipIndex 191

Lawrence M. Samkoff, MD, Associate Professor of Neurology at the School of Medicine and Dentistry, University of Rochester Medical Center,  Rochester, NY, USA Andrew D. Goodman, MD, Professor of Neurology, Chief of the Neuroimmunology Unit, and Director of the Multiple Sclerosis Center at the School of Medicine and Dentistry, University of Rochester Medical Center , Rochester, NY, USA

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• Contributors viiSeries Foreword xPreface xichapter 1 1EtiologySonya U. Steele and Ellen M. Mowrychapter 2 10Immunopathogenesis of Multiple SclerosisAnne H. Cross and Laura Picciochapter 3 18Diagnostic ProcessDalia Rotstein and Paul O’Connorchapter 4 29MRI in Diagnosis and Disease MonitoringMaría I. Gaitán and Daniel S. Reichchapter 5 45Relapsing MS: Disease Staging and Therapeutic AlgorithmsMohsen Khoshnam and Mark Freedmanchapter 6 57 Progressive MS Treatment AlgorithmsMegan H. Hyland and Jeffrey A. Cohenchapter 7 67Sex-Determined Issues in Multiple SclerosisCallene Momtazee and Barbara Giesserchapter 8 77Pediatric Multiple SclerosisRobert Thompson Stone and Brenda Banwellchapter 9 91Complementary and Alternative Medicine: Risks and BenefitsAllen C. Bowlingchapter 10 102Symptomatic Management of MSJessica Robb, Lawrence M. Samkoff, and Andrew D. Goodmanchapter 11 114Invisible Symptoms of MS: Fatigue, Depression, and CognitionLeigh E. Charvet, Benzi Kluzer, and Lauren B. Kruppchapter 12 122RehabilitationNesanet S. Mitiku, Alexius E. G. Sandoval, and George H. Kraftchapter 13 134Psychosocial Adaptation to Multiple SclerosisDavid J. Rintellchapter 14 144Transverse Myelitis and Acute Disseminated EncephalomyelitisBenjamin M. Greenbergchapter 15 153Neuromyelitis OpticaMarcelo Matiello and Brian G. Weinshenkerchapter 16 163NeurosarcoidosisThomas F. Scottchapter 17 169Lyme NeuroborreliosisErica Patrick and Eric Logigianchapter 18 178Neuro-Behçet SyndromeAksel Siva and Sabahattin SaipIndex 191