Dr Stuart Warren, Department of Chemistry, University of Cambridge, UKDr Warren is the author of the bestselling textbooks Organic Synthesis: The Disconnection Approach (Wiley), Organic Synthesis: Strategy and Control (Wiley) and Organic Chemistry (OUP).Dr Paul Wyatt, School of Chemistry, University of Bristol, UKDr Wyatt is Director of Undergraduate Studies for the School of Chemistry at Bristol University and also Director of BRISTOL ChemLabS - a HEFCE Centre for Excellence in Teaching & Learning. He is co-author, with Warren, of Organic Synthesis: Strategy and Control.

?The authors have succeeded admirably in the updating of a classic in the pedagogy of organic chemistry.? ( Journal of Medicinal Chemistry , August 2009) ?This book is suitable for advanced undergraduate students, researchers and professional chemists. Both the writing and the diagrams are simple and clear.? ( Reviews, May 2009)

• Preface ixGeneral References xi1. The Disconnection Approach 12. Basic Principles: Synthons and Reagents Synthesis of Aromatic Compounds 73. Strategy I: The Order of Events 174. One-Group C–X Disconnections 235. Strategy II: Chemoselectivity 296. Two-Group C–X Disconnections 357. Strategy III: Reversal of Polarity, Cyclisations, Summary of Strategy 458. Amine Synthesis 539. Strategy IV: Protecting Groups 6110. One Group C–C Disconnections I: Alcohols 6911. General Strategy A: Choosing a Disconnection 7712. Strategy V: Stereoselectivity A 8313. One Group C–C Disconnections II: Carbonyl Compounds 9314. Strategy VI: Regioselectivity 10115. Alkene Synthesis 10716. Strategy VII: Use of Acetylenes (Alkynes) 11517. Two-Group C–C Disconnections I: Diels-Alder Reactions 12118. Strategy VIII: Introduction to Carbonyl Condensations 12919. Two-Group C–C Disconnections II: 1,3-Difunctionalised Compounds 13320. Strategy IX: Control in Carbonyl Condensations 13921. Two-Group C–C Disconnections III: 1,5-Difunctionalised Compounds Conjugate (Michael) Addition and Robinson Annelation 15122. Strategy X: Aliphatic Nitro Compounds in Synthesis 16123. Two-Group Disconnections IV: 1,2-Difunctionalised Compounds 16724. Strategy XI: Radical Reactions in Synthesis 17725. Two-Group Disconnections V: 1,4-Difunctionalised Compounds 18526. Strategy XII: Reconnection 19327. Two-Group C–C Disconnections VI: 1,6-diCarbonyl Compounds 19928. General Strategy B: Strategy of Carbonyl Disconnections 20729. Strategy XIII: Introduction to Ring Synthesis: Saturated Heterocycles 21730. Three-Membered Rings 22931. Strategy XIV: Rearrangements in Synthesis 23732. Four-Membered Rings: Photochemistry in Synthesis 24533. Strategy XV: The Use of Ketenes in Synthesis 25134. Five-Membered Rings 25535. Strategy XVI: Pericyclic Reactions in Synthesis: Special Methods for Five-Membered Rings 26136. Six-Membered Rings 26937. General Strategy C: Strategy of Ring Synthesis 27938. Strategy XVII: Stereoselectivity B 28939. Aromatic Heterocycles 30140. General Strategy D: Advanced Strategy 313Index 325

Dr Stuart Warren, Department of Chemistry, University of Cambridge, UKDr Warren is the author of the bestselling textbooks Organic Synthesis: The Disconnection Approach (Wiley), Organic Synthesis: Strategy and Control (Wiley) and Organic Chemistry (OUP).Dr Paul Wyatt, School of Chemistry, University of Bristol, UKDr Wyatt is Director of Undergraduate Studies for the School of Chemistry at Bristol University and also Director of BRISTOL ChemLabS - a HEFCE Centre for Excellence in Teaching & Learning. He is co-author, with Warren, of Organic Synthesis: Strategy and Control.

?The authors have succeeded admirably in the updating of a classic in the pedagogy of organic chemistry.? ( Journal of Medicinal Chemistry , August 2009) ?This book is suitable for advanced undergraduate students, researchers and professional chemists. Both the writing and the diagrams are simple and clear.? ( Reviews, May 2009)

• Preface ixGeneral References xi1. The Disconnection Approach 12. Basic Principles: Synthons and Reagents Synthesis of Aromatic Compounds 73. Strategy I: The Order of Events 174. One-Group C–X Disconnections 235. Strategy II: Chemoselectivity 296. Two-Group C–X Disconnections 357. Strategy III: Reversal of Polarity, Cyclisations, Summary of Strategy 458. Amine Synthesis 539. Strategy IV: Protecting Groups 6110. One Group C–C Disconnections I: Alcohols 6911. General Strategy A: Choosing a Disconnection 7712. Strategy V: Stereoselectivity A 8313. One Group C–C Disconnections II: Carbonyl Compounds 9314. Strategy VI: Regioselectivity 10115. Alkene Synthesis 10716. Strategy VII: Use of Acetylenes (Alkynes) 11517. Two-Group C–C Disconnections I: Diels-Alder Reactions 12118. Strategy VIII: Introduction to Carbonyl Condensations 12919. Two-Group C–C Disconnections II: 1,3-Difunctionalised Compounds 13320. Strategy IX: Control in Carbonyl Condensations 13921. Two-Group C–C Disconnections III: 1,5-Difunctionalised Compounds Conjugate (Michael) Addition and Robinson Annelation 15122. Strategy X: Aliphatic Nitro Compounds in Synthesis 16123. Two-Group Disconnections IV: 1,2-Difunctionalised Compounds 16724. Strategy XI: Radical Reactions in Synthesis 17725. Two-Group Disconnections V: 1,4-Difunctionalised Compounds 18526. Strategy XII: Reconnection 19327. Two-Group C–C Disconnections VI: 1,6-diCarbonyl Compounds 19928. General Strategy B: Strategy of Carbonyl Disconnections 20729. Strategy XIII: Introduction to Ring Synthesis: Saturated Heterocycles 21730. Three-Membered Rings 22931. Strategy XIV: Rearrangements in Synthesis 23732. Four-Membered Rings: Photochemistry in Synthesis 24533. Strategy XV: The Use of Ketenes in Synthesis 25134. Five-Membered Rings 25535. Strategy XVI: Pericyclic Reactions in Synthesis: Special Methods for Five-Membered Rings 26136. Six-Membered Rings 26937. General Strategy C: Strategy of Ring Synthesis 27938. Strategy XVII: Stereoselectivity B 28939. Aromatic Heterocycles 30140. General Strategy D: Advanced Strategy 313Index 325