Antimicrobial Therapy in Veterinary Medicine

THE EDITORS Steeve Giguère, DVM, PhD, DACVIM, is Professor of Large Animal Internal Medicine and the Marguerite Hodgson Chair in Equine Studies at the College of Veterinary Medicine, University of Georgia, in Athens, Georgia. John F. Prescott, MA, VetMB, PhD, is Professor in the Department of Pathobiology at the University of Guelph in Guelph, Ontario. Patricia M. Dowling, DVM, MS, DACVIM, DACVCP, is Professor of Veterinary Clinical Pharmacology at the University of Saskatchewan in Saskatoon, Saskatchewan.

“Overall, this book provides an excellent resource for the whole topic of veterinary prescribing of antibacterial and antifungal drugs from both a veterinary clinical and a public health viewpoint.”  (Veterinary Record, 31 May 2014)“The result is a solid textbook highly recommended for any veterinary reference library.”  (Midwest Book Review, 1 March 2014)

• Contributors ixPreface xiiiImportant Notice xvAbbreviations xviiSection I General Principles of Antimicrobial Therapy 11 Antimicrobial Drug Action and Interaction: An Introduction 3Steeve Giguère2 Antimicrobial Susceptibility Testing Methods and Interpretation of Results 11Joseph E. Rubin3 Antimicrobial Resistance and its Epidemiology 21Patrick Boerlin and David G. White4 Principles of Antimicrobial Drug Bioavailability and Disposition 41J. Desmond Baggot and Steeve Giguère5 The Pharmacodynamics of Antimicrobial Agents 79Marilyn N. Martinez, Pierre-Louis Toutain, and John Turnidge6 Principles of Antimicrobial Drug Selection and Use 105Steeve Giguère7 Antimicrobial Stewardship in Animals 117J. Scott Weese, Stephen W. Page, and John F. PrescottSection II Classes of Antimicrobial Agents 1338 Beta-lactam Antibiotics: Penam Penicillins 135John F. Prescott9 Beta-lactam Antibiotics: Cephalosporins 153John F. Prescott10 Other Beta-lactam Antibiotics: Beta-lactamase Inhibitors, Carbapenems, and Monobactams 175John F. Prescott11 Peptide Antibiotics: Polymyxins, Glycopeptides, Bacitracin, and Fosfomycin 189Patricia M. Dowling12 Lincosamides, Pleuromutilins, and Streptogramins 199Steeve Giguère13 Macrolides, Azalides, and Ketolides 211Steeve Giguère14 Aminoglycosides and Aminocyclitols 233Patricia M. Dowling15 Tetracyclines 257Jérôme R.E. del Castillo16 Chloramphenicol, Thiamphenicol, and Florfenicol 269Patricia M. Dowling17 Sulfonamides, Diaminopyrimidines, and Their Combinations 279John F. Prescott18 Fluoroquinolones 295Steeve Giguère and Patricia M. Dowling19 Miscellaneous Antimicrobials: Ionophores, Nitrofurans, Nitroimidazoles, Rifamycins, and Others 315Patricia M. Dowling20 Antifungal Chemotherapy 333Steeve GiguèreSection III Special Considerations_35721 Prophylactic Use of Antimicrobial Agents, and Antimicrobial Chemotherapy for the Neutropenic Patient 359Steeve Giguère, Anthony C.G. Abrams-Ogg, and Stephen A. Kruth22 Performance Uses of Antimicrobial Agents and Non-antimicrobial Alternatives 379Thomas R. Shryock and Stephen W. Page23 Antimicrobial Therapy of Selected Organ Systems 395Patricia M. Dowling24 Antimicrobial Therapy of Selected Bacterial Infections 421Steeve Giguère25 Antimicrobial Drug Residues in Foods of Animal Origin 431Patricia M. Dowling26 Regulation of Antimicrobial Use in Animals 443Karolina Törneke and Christopher BolandSection IV A ntimicrobial Drug Use in Selected Animal Species 45527 Antimicrobial Drug Use in Horses 457Steeve Giguère and Tiago Afonso28 Antimicrobial Drug Use in Dogs and Cats 473Jane E. Sykes29 Antimicrobial Drug Use in Cattle 495Michael D. Apley and Johann F. Coetzee30 Antimicrobial Drug Use in Mastitis 519Sarah Wagner and Ron Erskine31 Antimicrobial Drug Use in Sheep and Goats 529Chris R. Clark32 Antimicrobial Drug Use in New World Camelids 541Christopher K. Cebra and Margaret L. Cebra33 Antimicrobial Drug Use in Swine 553David G.S. Burch34 Antimicrobial Drug Use in Poultry 569Charles L. Hofacre, Jenny A. Fricke, and Tom Inglis35 Antimicrobial Drug Use in Companion Birds 589Keven Flammer36 Antimicrobial Drug Use in Rabbits, Rodents, and Ferrets 601Colette L. Wheler37 Antimicrobial Drug Use in Reptiles 623Ramiro Isaza and Elliott R. Jacobson38 Antimicrobial Drug Use in Zoological Animals 637Ellen Wiedner and Robert P. Hunter39 Antimicrobial Drug Use in Aquaculture 645Renate Reimschuessel, Ron A. Miller, and Charles M. GiesekerIndex 663