Robert B. Raffa is the author of Drug-Receptor Thermodynamics: Introduction and Applications, published by Wiley.

• Contributors. Foreword (R. Tallarida). Preface. PRINCIPLES. Introduction: On the Relevance of Thermodynamics to Pharmacology (R. Raffa). Mathematical Models of the Drug--Receptor Interaction: Theory of Drug Action (R. Tallarida).Thermodynamic Concepts: Evolution and Applications (I. Klotz). A Brief History of Thermodynamics Terminology and Notation (R. Battino). General Thermodynamic Definitions and Equations (I. Haq, et al.). Thermodynamic Models of Drug--Receptor Interactions: A General Introduction (G. Klebe, et al.). Effector--Receptor Interactions: Origin and Development of Energetic Perspectives (I. Klotz). Measurement of Drug--Receptor Binding Constants (D. Winzor & W. Sawyer). Heat Capacity in Ligand--Receptor Interactions (V. Pliska) Early Applications of Thermodynamics to Drug--Receptor Interactions (R. Raffa). SPECIFIC APPLICATIONS. Thermodynamics of Adenosine (A1 and A2A) Receptor Interactions (P. Borea, et al.). Thermodynamics of Benzodiazepine Receptor Interactions (R. Raffa).Thermodynamics of Catecholamine Receptor Interactions (G. Weiland). Thermodynamics of Muscarinic Receptor Interactions (Y. Landry & J.-P. Gies). Thermodynamics of Nicotonic Receptor Interactions (H. Arias). Thermodynamics of Ionotropic GABA_A, Glycine and 5-HT_3-type Serotonin Receptor Interactions (G. Maksay). Thermodynamics of Opioid Receptor Interactions (R. Raffa). Thermodynamics of Serotonin Receptor Interactions (A. Dalpiaz, et al.). Thermodynamics and Structural Basis of Insulin Receptor Interactions with Phosphotyrosine Binding Domains (A. Farooq & M. Zhou). Thermodynamics of the Visual-pigment System (E. Ito & H. Suzuki). Thermodynamics of Protein Modules Involved in Tyrosine Kinase Signaling Pathways (J. Bradshaw, et al.). Thermodynamics of Antibody-Fc-receptor Interactions: IgE and FcRI, FCII (R. Ghirlando & H. Gould). Metal Ion Binding to the Conantokins: Inhibitors of Ion Channel Opening of the NMDA Receptor (M. Prorok & F. Castellino). METHODS/ADVANCED CONCEPTS. Direct Method for the Determination of Thermodynamic Quantities (R. O'Brien, et al.). Enthalpy--Entropy Compensation and Solvent Reorganization (E. Grunwald). Basics of Correlations: Relevance to Enthalpy--Entropy Compensation (R. Raffa & R. Tallarida). Thermodynamic Maps of Receptor--Ligand Pairs Reveal How Some Proteins Bind (C. Camacho, et al.). Thermodynamic Distributions of Heterogeneous Receptor Populations (M. José & J. José). Protein-Ligand Docking as an Energy Optimization Problem (M. Totrov & R. Abagyan). Prediction of Ligand--Receptor Binding Thermodynamics by Free Energy Force Field (FEFF) 3D-QSAR Analysis (J. Tokarski). Hydrophobic Mode-targeted, Algorithmically Designed Peptide Ligands as Modulators of Protein Thermodynamic Structure and Function (A. Mandell, et al.). Non-equilibrium Thermodynamics and Kinetics of the Multidrug Transporter (S. Caplan & R. Johnstone). Convergence of Recombinant Mutagenesis and Kinetics Interaction Analysis for Revealing Receptor Recognition Mechanisms and Designing Receptor Ligands (I. Chaiken, et al.). Index.