Familial Breast and Ovarian Cancer

Patrick J. Morrison is a consultant clinical geneticist with a special interest in cancer genetics, in the Northern Ireland Regional Genetics Service. He qualified with an MB BCh BAO in 1986 and an MD in 1993 from Queens' University Belfast. He held molecular biology and neurogenetics research fellowships from the Royal College of Physicians in Ireland from 1991–4. Morrison is a member of the UK Government's Human Genetics Commission, World Federation of Neurology Research Group in Huntingdon Disease, a steering group member on the International Collaborative group on hereditary breast and ovarian cancer (ICG-HBOC) and a council member of the Irish Society of Human Genetics. He is involved in many other genetics and cancer societies, and has published over 100 peer-reviewed articles on all aspects of genetics, particularly late onset neurogenetics diseases, familial cancers and insurance issues. Neva E. Haites is a Professor in Medical Genetics at the University of Aberdeen and Head of Service in Medical Genetics and Honorary Consultant Clinical Genetics, Grampian University Hospitals NHS Trust. Her clinical interests include families with an inherited predisposition to cancer. She is currently Chair the Cancer Genetics Sub-Group of the Scottish Cancer Group at the Scottish Office and Chair of the British Society of Human Genetics. Haites' research Interests include service models for familial cancer, molecular aspects of Charcot Marie Tooth disease, polycystic ovarian syndrome, talipes equino varus, and diagnosis and identification of genes implicated in sporadic and familial cancer.

'… this is a very good state of the art document of the current knowledge, covering most aspects of the genetic background and the clinical management of suspected familial breast and ovarian cancer in mid-2002 … for those in the phase of starting up a clinical service the book contains valuable information and would be very useful as a basic guide…'. Human Genetics

• Part I. Molecular Biology and Natural History: 1. Introduction Patrick Morrison, Shirley Hodgson and Neva Haites; 2. Overview of clinical genetics of breast cancer Neva Haites and Helen Gregory; 3. Cowden syndrome and related disorders Charis Eng; 4. Overview of clinical genetics of ovarian cancer Pierre Chappuis and Will Foulkes; 5. Ovarian cancer as part of HNPCC and other hereditary colon cancer syndromes Hans Vasen and M. A. Nooy; 6. Natural history of hereditary breast cancer Dominique Stoppa-Lyonnet, Will Foulkes and Pierre Chappuis; 7. Pathology of the breast and ovary in mutation carriers Sunil Lakhani and Adrienne M. Flanagan; 8. Risk estimation for familial breast and ovarian cancer Jenny Chang-Claude and Heiko Becher; Part II. Screening: 9. Experience of setting up a cancer genetics service Jonathon Gray; 10. Referral criteria for cancer genetics clinics Diana Eccles; 11. Service aspects of cancer genetic clinics Neva Haites and Shirley Hodgson; 12. Cultural and education aspects influencing development of cancer genetics services in different European countries Shirley Hodgson; 13. Screening, detection and survival patterns of breast and other cancers in high risk families Pål Møller and Michael Steel; 14. Screening for familial ovarian cancer Barnaby Rufford, Usha Menon and Ian Jacobs; Part III. Management: 15. Management of BRCA 1/2 mutation carriers Pierre Chappuis and Will Foulkes; 16. Management of ovarian cancer Dirk Brinkman and Ian Jacobs; 17. Prophylactic mastectomy in mutation carriers Gareth Evans, Fiona Lalloo and Andrew Balidam; 18. Psychosocial aspects of genetic counselling Steven Sutton and Alison Bish; 19. BRCA 1 and 2 testing: uptake and its measurement Lucy Brooks and Gareth Evans; 20. Ethical aspects Patrick Morrison and Michael Steel; 21. Gene therapy of breast and ovarian cancer Richard Kennedy and Patrick Johnston; 22. Future directions Patrick Morrison, Shirley Hodgson and Neva Haites.