Michael R. Von Korff, DSc, Johns Hopkins School of Hygiene and Public Health, is a Senior Investigator at the Group Health Center for Health Studies, Group Health Cooperative, Seattle, Washington. Kate M. Scott, PhD, is a Senior Lecturer in the Department of Psychological Medicine, School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand. Oye Gureje, DSc, FRCPsych, is Head of the Department of Psychiatry at University College Hospital, Ibadan, Nigeria.

'This groundbreaking book, based on state-of-the-art, rigorous epidemiologic surveys in Asia, Africa, the Middle East, Europe, and the Americas, describes the association between a range of childhood adversities, early onset mood and anxiety disorders, and the subsequent higher risks of developing chronic medical and pain conditions. This book should be required reading for all physicians, nurses, epidemiologists, and other health professionals because it provides extensive evidence of the importance of a biopsychosocial approach to patients with chronic illness and chronic pain.' Wayne Katon MD, University of Washington, Seattle

• 1. Global perspectives on mental-physical comorbidity Michael R. Von Korff; Part I. An Epidemiological Map of Mental-Physical Comorbidity: 2. The global burden of chronic physical disease Michael R. Von Korff; 3. The global burden of chronic pain Adley Tsang and Sing Lee; 4. World Mental Health Survey methods for studying mental-physical comorbidity Gemma Vilagut, Kathleen Saunders, and Jordi Alonso; 5. The pattern and nature of mental-physical comorbidity: specific or general Oye Gureje; 6. Age patterns in the prevalence of depressive and anxiety disorders by physical comorbidity status Kate M. Scott; Part II. Risk Factors for Mental-Physical Comorbidity: 7. The development of mental-physical comorbidity Kate M. Scott; 8. Childhood adversity, early-onset mental disorders and adult-onset asthma Kate M. Scott; 9. Childhood adversities, mental disorders and heart disease Huibert Burger; 10. Early childhood adversities and later hypertension Dan Stein, Kate M. Scott, and Michael R. Von Korff; 11. Early life psychosocial factors and adult-onset diabetes Carmen Lara; 12. Psychosocial stressors in childhood and adult-onset arthritis Michael R. Von Korff; 13. The role of childhood adversities in adult-onset spinal pain Koen Demyttenaere and Ronny Bruffaerts; 14. Childhood adversities and adult obesity Ronny Bruffaerts and Koen Demyttenaere; 15. Linking depression-anxiety disorders and headache in a developmental perspective: the role of childhood family adversities Adley Tsang and Sing Lee; 16. Women, depression and mental-physical comorbidity: chronic pain as a mediating factor Oye Gureje; Part III. Consequences of Mental-Physical Comorbidity: 17. Understanding consequences of mental-physical comorbidity Michael R. Von Korff; 18. Disability and treatment of specific mental and physical disorders Johan Ormel, Maria Petukhova, Michael R. Von Korff, and Ronald C. Kessler; 19. Mental-physical comorbidity and its relationship with disability Kate M. Scott; 20. Disability in 'pure' vs. 'comorbid' mental and physical conditions Paul K. Crane; 21. Labor force participation, unemployment and mental-physical comorbidity Michael R. Von Korff; 22. Perceived stigma and mental-physical comorbidity Jordi Alonso, Andrea Buron, and Gemma Vilagut; 23. How physical comorbidity affects treatment of major depression in developing and developed countries Oye Gureje; 24. Mental-physical comorbidity and predicted mortality Huibert Burger; Part IV. Implications: 25. Research implications Evelyn Bromet and Michael R. Von Korff; 26. Clinical implications Gregory E. Simon; 27. Policy implications Sergio Aguilar-Gaxiola; Appendices.

Michael R. Von Korff, DSc, Johns Hopkins School of Hygiene and Public Health, is a Senior Investigator at the Group Health Center for Health Studies, Group Health Cooperative, Seattle, Washington. Kate M. Scott, PhD, is a Senior Lecturer in the Department of Psychological Medicine, School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand. Oye Gureje, DSc, FRCPsych, is Head of the Department of Psychiatry at University College Hospital, Ibadan, Nigeria.

'This groundbreaking book, based on state-of-the-art, rigorous epidemiologic surveys in Asia, Africa, the Middle East, Europe, and the Americas, describes the association between a range of childhood adversities, early onset mood and anxiety disorders, and the subsequent higher risks of developing chronic medical and pain conditions. This book should be required reading for all physicians, nurses, epidemiologists, and other health professionals because it provides extensive evidence of the importance of a biopsychosocial approach to patients with chronic illness and chronic pain.' Wayne Katon MD, University of Washington, Seattle

• 1. Global perspectives on mental-physical comorbidity Michael R. Von Korff; Part I. An Epidemiological Map of Mental-Physical Comorbidity: 2. The global burden of chronic physical disease Michael R. Von Korff; 3. The global burden of chronic pain Adley Tsang and Sing Lee; 4. World Mental Health Survey methods for studying mental-physical comorbidity Gemma Vilagut, Kathleen Saunders, and Jordi Alonso; 5. The pattern and nature of mental-physical comorbidity: specific or general Oye Gureje; 6. Age patterns in the prevalence of depressive and anxiety disorders by physical comorbidity status Kate M. Scott; Part II. Risk Factors for Mental-Physical Comorbidity: 7. The development of mental-physical comorbidity Kate M. Scott; 8. Childhood adversity, early-onset mental disorders and adult-onset asthma Kate M. Scott; 9. Childhood adversities, mental disorders and heart disease Huibert Burger; 10. Early childhood adversities and later hypertension Dan Stein, Kate M. Scott, and Michael R. Von Korff; 11. Early life psychosocial factors and adult-onset diabetes Carmen Lara; 12. Psychosocial stressors in childhood and adult-onset arthritis Michael R. Von Korff; 13. The role of childhood adversities in adult-onset spinal pain Koen Demyttenaere and Ronny Bruffaerts; 14. Childhood adversities and adult obesity Ronny Bruffaerts and Koen Demyttenaere; 15. Linking depression-anxiety disorders and headache in a developmental perspective: the role of childhood family adversities Adley Tsang and Sing Lee; 16. Women, depression and mental-physical comorbidity: chronic pain as a mediating factor Oye Gureje; Part III. Consequences of Mental-Physical Comorbidity: 17. Understanding consequences of mental-physical comorbidity Michael R. Von Korff; 18. Disability and treatment of specific mental and physical disorders Johan Ormel, Maria Petukhova, Michael R. Von Korff, and Ronald C. Kessler; 19. Mental-physical comorbidity and its relationship with disability Kate M. Scott; 20. Disability in 'pure' vs. 'comorbid' mental and physical conditions Paul K. Crane; 21. Labor force participation, unemployment and mental-physical comorbidity Michael R. Von Korff; 22. Perceived stigma and mental-physical comorbidity Jordi Alonso, Andrea Buron, and Gemma Vilagut; 23. How physical comorbidity affects treatment of major depression in developing and developed countries Oye Gureje; 24. Mental-physical comorbidity and predicted mortality Huibert Burger; Part IV. Implications: 25. Research implications Evelyn Bromet and Michael R. Von Korff; 26. Clinical implications Gregory E. Simon; 27. Policy implications Sergio Aguilar-Gaxiola; Appendices.

Michael R. Von Korff, DSc, Johns Hopkins School of Hygiene and Public Health, is a Senior Investigator at the Group Health Center for Health Studies, Group Health Cooperative, Seattle, Washington. Kate M. Scott, PhD, is a Senior Lecturer in the Department of Psychological Medicine, School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand. Oye Gureje, DSc, FRCPsych, is Head of the Department of Psychiatry at University College Hospital, Ibadan, Nigeria.

'This groundbreaking book, based on state-of-the-art, rigorous epidemiologic surveys in Asia, Africa, the Middle East, Europe, and the Americas, describes the association between a range of childhood adversities, early onset mood and anxiety disorders, and the subsequent higher risks of developing chronic medical and pain conditions. This book should be required reading for all physicians, nurses, epidemiologists, and other health professionals because it provides extensive evidence of the importance of a biopsychosocial approach to patients with chronic illness and chronic pain.' Wayne Katon MD, University of Washington, Seattle

• 1. Global perspectives on mental-physical comorbidity Michael R. Von Korff; Part I. An Epidemiological Map of Mental-Physical Comorbidity: 2. The global burden of chronic physical disease Michael R. Von Korff; 3. The global burden of chronic pain Adley Tsang and Sing Lee; 4. World Mental Health Survey methods for studying mental-physical comorbidity Gemma Vilagut, Kathleen Saunders, and Jordi Alonso; 5. The pattern and nature of mental-physical comorbidity: specific or general Oye Gureje; 6. Age patterns in the prevalence of depressive and anxiety disorders by physical comorbidity status Kate M. Scott; Part II. Risk Factors for Mental-Physical Comorbidity: 7. The development of mental-physical comorbidity Kate M. Scott; 8. Childhood adversity, early-onset mental disorders and adult-onset asthma Kate M. Scott; 9. Childhood adversities, mental disorders and heart disease Huibert Burger; 10. Early childhood adversities and later hypertension Dan Stein, Kate M. Scott, and Michael R. Von Korff; 11. Early life psychosocial factors and adult-onset diabetes Carmen Lara; 12. Psychosocial stressors in childhood and adult-onset arthritis Michael R. Von Korff; 13. The role of childhood adversities in adult-onset spinal pain Koen Demyttenaere and Ronny Bruffaerts; 14. Childhood adversities and adult obesity Ronny Bruffaerts and Koen Demyttenaere; 15. Linking depression-anxiety disorders and headache in a developmental perspective: the role of childhood family adversities Adley Tsang and Sing Lee; 16. Women, depression and mental-physical comorbidity: chronic pain as a mediating factor Oye Gureje; Part III. Consequences of Mental-Physical Comorbidity: 17. Understanding consequences of mental-physical comorbidity Michael R. Von Korff; 18. Disability and treatment of specific mental and physical disorders Johan Ormel, Maria Petukhova, Michael R. Von Korff, and Ronald C. Kessler; 19. Mental-physical comorbidity and its relationship with disability Kate M. Scott; 20. Disability in 'pure' vs. 'comorbid' mental and physical conditions Paul K. Crane; 21. Labor force participation, unemployment and mental-physical comorbidity Michael R. Von Korff; 22. Perceived stigma and mental-physical comorbidity Jordi Alonso, Andrea Buron, and Gemma Vilagut; 23. How physical comorbidity affects treatment of major depression in developing and developed countries Oye Gureje; 24. Mental-physical comorbidity and predicted mortality Huibert Burger; Part IV. Implications: 25. Research implications Evelyn Bromet and Michael R. Von Korff; 26. Clinical implications Gregory E. Simon; 27. Policy implications Sergio Aguilar-Gaxiola; Appendices.