Handbook of Experimental Neurology

TurgutTatlisumak received his neurology training in the Helsinki University Central Hospital. He made his PhD thesis work on experimental brain ischemia and magnetic resonance imaging at the University of Massachusetts. His research field is clinical and experimental stroke and magnetic resonance imaging. He holds board certificates in neurology and health care administration in Finland. He is currently an associate professor and the Vice Chair at the Department of Neurology, Helsinki University Central Hospital and the director of the Experimental Magnetic Resonance Imaging Laboratory. Dr. Tatlisumak is a Fellow of the American Heart Association. He is an awarded teacher and holds a degree in teaching sciences. Marc Fisher received his medical from the SUNY at Syracuse and then trained in medicine at the University of Wisconsin and neurology at the Medical Center of Vermont. He has been at the University of Massachusetts Medical School since 1978 and currently holds the position of Professor and Vice-Chairman in the neurology department. He performs clinical activities approximately 50% of the time with a special emphasis on patients with cerebrovascular disorders and multiple sclerosis. He has directed an animal stroke research laboratory for more than 15 years that has emphasized the use of novel MRI techniques to evaluate stroke evolution and to assess therapeutic interventions in vivo. He has participated in many clinical stroke trials as a member of the steering committee. He has published extensively in both of these areas with 156 peer reviewed publications and has edited 10 textbooks. He has worked closely with the pharmaceutical industry in the development of novel stroke therapies as well as designing and implementing clinical trials for acute stroke therapies.

• Preface; Part I. Principles and General Methods: 1. Introduction: Animal modelling - a precious tool for developing remedies to neurological diseases Turgut Tatlisumak and Marc Fisher; 2. Ethical issues, welfare laws, and regulations David Whittaker; 3. Housing, feeding, and maintenance of rodents Robert W. Kemp; 4. Identification of individual animals Turgut Tatlisumak and Daniel Strbian; 5. Analgesia, anesthesia, and postoperative care in laboratory animals Naoya Masutomi and Makoto Shibutani; 6. Euthanasia in small animals Turgut Tatlisumak; 7. Various surgical procedures in rodents René Remie; 8. Genetically engineered animals Carolina M. Maier, Lilly Hsieh and Pak H. Chan; 9. Imaging in experimental neurology Marc Fisher, Eng H. Lo and Michael Lev; 10. Safety in animal facilities Tarja Kohila; 11. Behavioural testing in small animal models: ischemic stroke Larry B. Goldstein; 12. Methods for analysing brain tissue Päivi Liesi; 13. Targeting molecular constructs of cellular function and injury through in vitro and in vivo experimental models Zhao Zhong Chong, Faqi Li and Kenneth Maiese; 14. Neuroimmunology and immune-related neuropathologies Bao-Guo Xiao and Hans Link; 15. Animal models of sex differences in non-reproductive brain functions George T. Taylor, Juergen Weiss and Frank Zimmermann; 16. The ependymal route for central nervous system gene therapy Erica Butti, Gianvito Martino and Roberto Furlan; 17. Neural transplantation Stephen B Dunnett, Eduardo M. Torres, Monte A. Gates, and Rosemary A. Fricker-Gates; Part II. Experimental Models of Major Neurological Diseases: 18. Focal brain ischemia models in rodents Fuhai Li and Turgut Tatlisumak; 19. Rodent models of global brain ischemia Julia Kofler and Richard J. Traystman; 20. Rodent models of hemorrhagic stroke Fatima A. Sehba and Joshua B. Bederson; 21. In-vivo models of traumatic brain injury Ronen R Leker and Shlomi Constantini; 22. Experimental models for the study of CNS tumors Taichang Jang and Lawrence Recht; 23. Experimental models for demyelinating diseases Jason M Link, Richard E. Jones, Halina Offner and Arthur A Vandenbark; 24. Animal models of Parkinson's disease Anumantha G. Kathasamy and Siddharth Kaul; 25. Animal models of epilepsy Ricardo M. Arida, Alexandre V. Silva, Margareth R. Priel, and Esper A. Cavalheiro; 26. Experimental models of hydrocephalus Osaama H. Khan and Marc R. Del Bigio; 27. Rodent models of experimental bacterial infections in the CNS Tammy Kielian; 28. Experimental models of motor neuron disease Ruth Danzeisen, Birgit Schwalenstöcker and Albert C Ludolph; 29. Animal models for sleep disorders Seiji Nishino and Nobuhiro Fujiki; 30. Experimental models of muscle diseases Anu Suomalainen, Katja E. Peltola, Anders Paetau and Carina Wallgren-Pettersson.