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• PART I Principles of Immune Response1. The Human Immune Response2. Organization of the Immune System3. Innate Immunity4. Antigen Receptor Genes, Gene Products, and Co-Receptors5. The Major Histocompatibility Complex6. Antigens and Antigen Presentation7. B-Cell Development and Differentiation8. Immunoglobulin Function9. T-Cell Development10. T-Cell Activation and Tolerance11. Helper T-Cell Subsets and Control of the Inflammatory Response12. Cytotoxic T Lymphocytes and Natural Killer Cells13. Regulatory Immune Cells14. Cytokines and Cytokine Receptors15. Chemokines and Chemokine Receptors16. Lymphocyte Adhesion and Trafficking17. Death Pathways and ImmunogenicityPART II Fundamentals of Host-Environmental Interactions18. Human Genomics in Immunology19. Regulatory RNA in Immunologic Diseases20. Immunometabolism21. Immune Deficiencies at the Extremes of Age22. The Microbiota in Immunity and InflammationPART III Host Defenses to Infectious Agents23. Immunology of the Skin24. Immunology of Mucosal Surfaces25. Host Defenses to Viruses26. Host Defenses to Intracellular Bacteria27. Host Defenses to Extracellular Bacteria, Including Spirochetes28. Host Defenses to Fungi29. Host Defenses to Protozoa30. Host Defenses to Helminth Infection31. Emerging Pandemic Infectious Disease ThreatsPART IV Immune Deficiency and Immune Regulatory Disorders32. Approach to the Evaluation of the Patient With Suspected Immunodeficiency33. Primary Antibody Deficiencies34. Primary T-Cell Immunodeficiencies35. Genetic Disorders of Interferons-, Interleukin-17, Interleukin-18, and Nuclear Factor-?B-Mediated Immunity36. Hemophagocytic Lymphohistiocytosis37. Autoinflammatory Syndromes38. Immune Regulatory Disorders39. Neutrophils and Neutrophil Disorders40. Complement and Complement Disorders41. Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome42. Autoantibody-Mediated Phenocopies of Primary Immunodeficiency DiseasesPART V Allergic Diseases43. Allergic Airway Diseases44. Mast Cells and Mast Cell Disorders45. Eosinophils and Eosinophilic Disorders46. Urticaria, Angioedema, and Anaphylaxis47. Allergic Reactions to Stinging and Biting Insects48. Atopic and Contact Dermatitis49. Food Allergy50. Drug HypersensitivityPART VI Systemic Immune Diseases51. Mechanisms of Autoimmunity52. Systemic Lupus Erythematosus53. Rheumatoid Arthritis54. Juvenile Idiopathic Arthritis55. Sjögren’s Syndrome56. Scleroderma-Systemic Sclerosis57. Inflammatory Muscle Diseases58. Spondyloarthritis59. Small- and Medium-Vessel Primary Vasculitis60. Large Vessel Vasculitides61. Antiphospholipid SyndromePART VII Organ-Specific Inflammatory Disease62. Immunohematologic Disorders63. Bullous Diseases of the Skin and Mucous Membranes64. Immunology of Psoriasis65. Myasthenia Gravis66. Multiple Sclerosis67. Autoimmune Peripheral Neuropathies68. Immunologic Renal Diseases69. Immunologic Mechanisms of Atherosclerosis and Myocarditis70. Autoimmune Thyroid Diseases71. Type 1 Diabetes72. Immunologic Lung Diseases, 91973. Chronic Obstructive Pulmonary Disease and Emphysema74. Immunologic Ocular Disease75. Immunologic Diseases of the Gastrointestinal Tract76. Inflammatory Hepatobiliary DiseasesPART VIII Immunology and Immunotherapy of Neoplasia77. Lymphoid Leukemias78. Lymphomas79. Monoclonal Gammopathies80. Immune Responses to Solid Tumors and Immune Checkpoint Therapy81. CAR T-Cell TherapyPART IX Medical Management of Immunological Diseases82. Immunoglobulin Therapy: Replacement and Immunomodulation83. Glucocorticoids84. Immunomodulating Drugs85. Protein Kinase Antagonists86. Biologic Response Modifiers87. Vaccines88. Allergen Immunotherapy for Allergic DiseasesPART X Transplantation89. Solid Organ Transplantation: Rejection, Immunosuppression, and Tolerance90. Allogeneic Transplantation for Immunodeficiency91. Gene Therapy for Primary Immune Deficiency Diseases92. Hematopoietic Stem Cell Transplantation for Malignant DiseasesPART XI Diagnostic Immunology93. Flow Cytometry94. Assessment of Functional Immune Responses in Lymphocytes95. Assessment of Neutrophil Function96. Assessment of Human Allergic DiseasesAppendix1: Selected CD Molecules and Their Characteristics2: Laboratory Reference Values

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• PART I Principles of Immune Response1. The Human Immune Response2. Organization of the Immune System3. Innate Immunity4. Antigen Receptor Genes, Gene Products, and Co-Receptors5. The Major Histocompatibility Complex6. Antigens and Antigen Presentation7. B-Cell Development and Differentiation8. Immunoglobulin Function9. T-Cell Development10. T-Cell Activation and Tolerance11. Helper T-Cell Subsets and Control of the Inflammatory Response12. Cytotoxic T Lymphocytes and Natural Killer Cells13. Regulatory Immune Cells14. Cytokines and Cytokine Receptors15. Chemokines and Chemokine Receptors16. Lymphocyte Adhesion and Trafficking17. Death Pathways and ImmunogenicityPART II Fundamentals of Host-Environmental Interactions18. Human Genomics in Immunology19. Regulatory RNA in Immunologic Diseases20. Immunometabolism21. Immune Deficiencies at the Extremes of Age22. The Microbiota in Immunity and InflammationPART III Host Defenses to Infectious Agents23. Immunology of the Skin24. Immunology of Mucosal Surfaces25. Host Defenses to Viruses26. Host Defenses to Intracellular Bacteria27. Host Defenses to Extracellular Bacteria, Including Spirochetes28. Host Defenses to Fungi29. Host Defenses to Protozoa30. Host Defenses to Helminth Infection31. Emerging Pandemic Infectious Disease ThreatsPART IV Immune Deficiency and Immune Regulatory Disorders32. Approach to the Evaluation of the Patient With Suspected Immunodeficiency33. Primary Antibody Deficiencies34. Primary T-Cell Immunodeficiencies35. Genetic Disorders of Interferons-, Interleukin-17, Interleukin-18, and Nuclear Factor-?B-Mediated Immunity36. Hemophagocytic Lymphohistiocytosis37. Autoinflammatory Syndromes38. Immune Regulatory Disorders39. Neutrophils and Neutrophil Disorders40. Complement and Complement Disorders41. Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome42. Autoantibody-Mediated Phenocopies of Primary Immunodeficiency DiseasesPART V Allergic Diseases43. Allergic Airway Diseases44. Mast Cells and Mast Cell Disorders45. Eosinophils and Eosinophilic Disorders46. Urticaria, Angioedema, and Anaphylaxis47. Allergic Reactions to Stinging and Biting Insects48. Atopic and Contact Dermatitis49. Food Allergy50. Drug HypersensitivityPART VI Systemic Immune Diseases51. Mechanisms of Autoimmunity52. Systemic Lupus Erythematosus53. Rheumatoid Arthritis54. Juvenile Idiopathic Arthritis55. Sjögren’s Syndrome56. Scleroderma-Systemic Sclerosis57. Inflammatory Muscle Diseases58. Spondyloarthritis59. Small- and Medium-Vessel Primary Vasculitis60. Large Vessel Vasculitides61. Antiphospholipid SyndromePART VII Organ-Specific Inflammatory Disease62. Immunohematologic Disorders63. Bullous Diseases of the Skin and Mucous Membranes64. Immunology of Psoriasis65. Myasthenia Gravis66. Multiple Sclerosis67. Autoimmune Peripheral Neuropathies68. Immunologic Renal Diseases69. Immunologic Mechanisms of Atherosclerosis and Myocarditis70. Autoimmune Thyroid Diseases71. Type 1 Diabetes72. Immunologic Lung Diseases, 91973. Chronic Obstructive Pulmonary Disease and Emphysema74. Immunologic Ocular Disease75. Immunologic Diseases of the Gastrointestinal Tract76. Inflammatory Hepatobiliary DiseasesPART VIII Immunology and Immunotherapy of Neoplasia77. Lymphoid Leukemias78. Lymphomas79. Monoclonal Gammopathies80. Immune Responses to Solid Tumors and Immune Checkpoint Therapy81. CAR T-Cell TherapyPART IX Medical Management of Immunological Diseases82. Immunoglobulin Therapy: Replacement and Immunomodulation83. Glucocorticoids84. Immunomodulating Drugs85. Protein Kinase Antagonists86. Biologic Response Modifiers87. Vaccines88. Allergen Immunotherapy for Allergic DiseasesPART X Transplantation89. Solid Organ Transplantation: Rejection, Immunosuppression, and Tolerance90. Allogeneic Transplantation for Immunodeficiency91. Gene Therapy for Primary Immune Deficiency Diseases92. Hematopoietic Stem Cell Transplantation for Malignant DiseasesPART XI Diagnostic Immunology93. Flow Cytometry94. Assessment of Functional Immune Responses in Lymphocytes95. Assessment of Neutrophil Function96. Assessment of Human Allergic DiseasesAppendix1: Selected CD Molecules and Their Characteristics2: Laboratory Reference Values

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• PART I Principles of Immune Response1. The Human Immune Response2. Organization of the Immune System3. Innate Immunity4. Antigen Receptor Genes, Gene Products, and Co-Receptors5. The Major Histocompatibility Complex6. Antigens and Antigen Presentation7. B-Cell Development and Differentiation8. Immunoglobulin Function9. T-Cell Development10. T-Cell Activation and Tolerance11. Helper T-Cell Subsets and Control of the Inflammatory Response12. Cytotoxic T Lymphocytes and Natural Killer Cells13. Regulatory Immune Cells14. Cytokines and Cytokine Receptors15. Chemokines and Chemokine Receptors16. Lymphocyte Adhesion and Trafficking17. Death Pathways and ImmunogenicityPART II Fundamentals of Host-Environmental Interactions18. Human Genomics in Immunology19. Regulatory RNA in Immunologic Diseases20. Immunometabolism21. Immune Deficiencies at the Extremes of Age22. The Microbiota in Immunity and InflammationPART III Host Defenses to Infectious Agents23. Immunology of the Skin24. Immunology of Mucosal Surfaces25. Host Defenses to Viruses26. Host Defenses to Intracellular Bacteria27. Host Defenses to Extracellular Bacteria, Including Spirochetes28. Host Defenses to Fungi29. Host Defenses to Protozoa30. Host Defenses to Helminth Infection31. Emerging Pandemic Infectious Disease ThreatsPART IV Immune Deficiency and Immune Regulatory Disorders32. Approach to the Evaluation of the Patient With Suspected Immunodeficiency33. Primary Antibody Deficiencies34. Primary T-Cell Immunodeficiencies35. Genetic Disorders of Interferons-, Interleukin-17, Interleukin-18, and Nuclear Factor-?B-Mediated Immunity36. Hemophagocytic Lymphohistiocytosis37. Autoinflammatory Syndromes38. Immune Regulatory Disorders39. Neutrophils and Neutrophil Disorders40. Complement and Complement Disorders41. Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome42. Autoantibody-Mediated Phenocopies of Primary Immunodeficiency DiseasesPART V Allergic Diseases43. Allergic Airway Diseases44. Mast Cells and Mast Cell Disorders45. Eosinophils and Eosinophilic Disorders46. Urticaria, Angioedema, and Anaphylaxis47. Allergic Reactions to Stinging and Biting Insects48. Atopic and Contact Dermatitis49. Food Allergy50. Drug HypersensitivityPART VI Systemic Immune Diseases51. Mechanisms of Autoimmunity52. Systemic Lupus Erythematosus53. Rheumatoid Arthritis54. Juvenile Idiopathic Arthritis55. Sjögren’s Syndrome56. Scleroderma-Systemic Sclerosis57. Inflammatory Muscle Diseases58. Spondyloarthritis59. Small- and Medium-Vessel Primary Vasculitis60. Large Vessel Vasculitides61. Antiphospholipid SyndromePART VII Organ-Specific Inflammatory Disease62. Immunohematologic Disorders63. Bullous Diseases of the Skin and Mucous Membranes64. Immunology of Psoriasis65. Myasthenia Gravis66. Multiple Sclerosis67. Autoimmune Peripheral Neuropathies68. Immunologic Renal Diseases69. Immunologic Mechanisms of Atherosclerosis and Myocarditis70. Autoimmune Thyroid Diseases71. Type 1 Diabetes72. Immunologic Lung Diseases, 91973. Chronic Obstructive Pulmonary Disease and Emphysema74. Immunologic Ocular Disease75. Immunologic Diseases of the Gastrointestinal Tract76. Inflammatory Hepatobiliary DiseasesPART VIII Immunology and Immunotherapy of Neoplasia77. Lymphoid Leukemias78. Lymphomas79. Monoclonal Gammopathies80. Immune Responses to Solid Tumors and Immune Checkpoint Therapy81. CAR T-Cell TherapyPART IX Medical Management of Immunological Diseases82. Immunoglobulin Therapy: Replacement and Immunomodulation83. Glucocorticoids84. Immunomodulating Drugs85. Protein Kinase Antagonists86. Biologic Response Modifiers87. Vaccines88. Allergen Immunotherapy for Allergic DiseasesPART X Transplantation89. Solid Organ Transplantation: Rejection, Immunosuppression, and Tolerance90. Allogeneic Transplantation for Immunodeficiency91. Gene Therapy for Primary Immune Deficiency Diseases92. Hematopoietic Stem Cell Transplantation for Malignant DiseasesPART XI Diagnostic Immunology93. Flow Cytometry94. Assessment of Functional Immune Responses in Lymphocytes95. Assessment of Neutrophil Function96. Assessment of Human Allergic DiseasesAppendix1: Selected CD Molecules and Their Characteristics2: Laboratory Reference Values