This volume contains the Proceedings of the 8th International Symposium on Magnesium. It presents research and applications in order to interface between medical doctors, clinicians and scientists responsible for magnesium involvement in the pathogenesis of diseases, its biological significance, metabolism and many other utilizations which are associated with membranes and cells. The topics which are discussed concern mechanisms of the mode of action of free magnesium cations, hydrated cations and magnesium-linked cations.