David Wong is Associate Dean of Research, Professor of Oral Biology, Oral Biology & Medicine, and Director of Dental Research Institute at UCLA. Dr. Wong is a dentist-scientist focusing his research on the molecular determinants (genomic and proteomic) of head and neck cancer. His research has been continuously funded by the NIDCR and NCI for the past 18 years. He has achieved two 4-year award U01 awards from the NIDCR for the creation of the UCLA Collaborative Oral Fluid Diagnostic Research Center and the Human Salivary Proteome project.

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• Contributors viiiForeword xvPreface xviiAcknowledgment xviiiI Background and Foundation1 Salivary Gland Development and Regeneration 3Sarah M. Knox and Matthew P. Hoffman2 Salivary Gland Physiology Relevant to Diagnostics 14Victor G. Romanenko and James E. Melvin3 Saliva: Properties and Functions 27Arie van Nieuw Amerongen, Enno C.I. Veerman, and Arjan Vissink4 Saliva Collectors 37Arjan Vissink, Andy Wolff, and Enno C.I. Veerman5 Salivary Secretion in Health and Disease 60Michael D. Turner and Jonathan A. Ship6 Processing and Storage of Saliva Samples 69Enno C.I. Veerman, Arjan Vissink, David T. Wong, and Arie van Nieuw AmerongenII Saliva Diagnostics7 Historical Perspectives and Present 79Frank G. Oppenheim8 Diagnostics Other Than Blood 94Sudhir Srivastava and Karl Krueger9 Perceptions of Saliva: Relevance to Clinical Diagnostics 104Sreenivas Koka and David T. Wong10 Saliva-Based Diagnostic Technologies: Highlights of the NIDCR's Program 111Eleni Kousvelari, John T. McDevitt, Daniel Malamud, David T. Wong, and David R. Walt11 Human Salivary Proteomics 122Shen Hu, Markus Hardt, Susan J. Fisher, David T. Wong, John R. Yates, James E. Melvin, and Joseph A. Loo12 Genomic Targets in Saliva 129Bernhard G. Zimmermann, Zhanzhi Hu, and David T. Wong13 Point-of-Care Diagnostics for Infectious diseases 136Paul L.A.M. Corstjens, Daniel Malamud14 Dental Caries Risk Assessment 150Paul C. Denny and Patricia A. Denny15 Periodontal Disease 156Christoph A. Ramseier, Thiago Morelli, Janet S. Kinney, Meghan Dubois, Lindsay Rayburn, and William Giannobile16 Role of Saliva in Detection of Substance Abuse 169Uttam Garg and Lance Presley17 Head and Neck Cancer 180Joseph A. Califano and Suhail K. Mithani18 Sjogren's Syndrome 189Philip C. Fox19 Salivary Gland Dysfunction Associated with Systemic Disease 198Nelson L. Rhodus20 Progression and Treatment Evaluation in Diseases Affecting Salivary Glands 214Jiska M. Meijer, Cees G.M. Kallenberg, and Arjan Vissink21 The Uses of Saliva in Forensic Genetics 226Jack Ballantyne and Jane Juusola22 SPKB—Salivary Proteome Knowledge Base: A Platform for Collaborative Proteomics Research 233Weihong Yan, Weixia Yu, Shawn Than, Renli Qiao, D. Stott Parker, Joseph A. Loo, and David T. WongIII Saliva Diagnostics—A New Industry23 Commercialization of Oral Fluid Products and Technologies 243R. Sam Niedbala24 Coverage and Reimbursement for Salivary Diagnostic Tests 255James J. Crall25 Saliva Diagnostics in the Dentist's and Physician's Office 263Chakwan Siew and Milton V. Marshall26 Salivary Hormones in Research and Diagnostics 270Douglas A. Granger, Christine K. Fortunato, Leah C. Hibel27 Crossroads Between Saliva Diagnostics and Salivary Gland Gene Therapy 278Bruce J. Baum, Ana P. Cotrim, Corinne M. Goldsmith, Fumi Mineshiba, Senrong Qi, Gabor Z. Racz, Yuval Samuni, Takayuki Sugito, Antonis Voutetakis, and Changyu Zheng28 Saliva Diagnostics—A New Industry 288Stuart R. Smith, David T. Wong, and R. Michael BuchIndex 295

David Wong is Associate Dean of Research, Professor of Oral Biology, Oral Biology & Medicine, and Director of Dental Research Institute at UCLA. Dr. Wong is a dentist-scientist focusing his research on the molecular determinants (genomic and proteomic) of head and neck cancer. His research has been continuously funded by the NIDCR and NCI for the past 18 years. He has achieved two 4-year award U01 awards from the NIDCR for the creation of the UCLA Collaborative Oral Fluid Diagnostic Research Center and the Human Salivary Proteome project.

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• Contributors viiiForeword xvPreface xviiAcknowledgment xviiiI Background and Foundation1 Salivary Gland Development and Regeneration 3Sarah M. Knox and Matthew P. Hoffman2 Salivary Gland Physiology Relevant to Diagnostics 14Victor G. Romanenko and James E. Melvin3 Saliva: Properties and Functions 27Arie van Nieuw Amerongen, Enno C.I. Veerman, and Arjan Vissink4 Saliva Collectors 37Arjan Vissink, Andy Wolff, and Enno C.I. Veerman5 Salivary Secretion in Health and Disease 60Michael D. Turner and Jonathan A. Ship6 Processing and Storage of Saliva Samples 69Enno C.I. Veerman, Arjan Vissink, David T. Wong, and Arie van Nieuw AmerongenII Saliva Diagnostics7 Historical Perspectives and Present 79Frank G. Oppenheim8 Diagnostics Other Than Blood 94Sudhir Srivastava and Karl Krueger9 Perceptions of Saliva: Relevance to Clinical Diagnostics 104Sreenivas Koka and David T. Wong10 Saliva-Based Diagnostic Technologies: Highlights of the NIDCR's Program 111Eleni Kousvelari, John T. McDevitt, Daniel Malamud, David T. Wong, and David R. Walt11 Human Salivary Proteomics 122Shen Hu, Markus Hardt, Susan J. Fisher, David T. Wong, John R. Yates, James E. Melvin, and Joseph A. Loo12 Genomic Targets in Saliva 129Bernhard G. Zimmermann, Zhanzhi Hu, and David T. Wong13 Point-of-Care Diagnostics for Infectious diseases 136Paul L.A.M. Corstjens, Daniel Malamud14 Dental Caries Risk Assessment 150Paul C. Denny and Patricia A. Denny15 Periodontal Disease 156Christoph A. Ramseier, Thiago Morelli, Janet S. Kinney, Meghan Dubois, Lindsay Rayburn, and William Giannobile16 Role of Saliva in Detection of Substance Abuse 169Uttam Garg and Lance Presley17 Head and Neck Cancer 180Joseph A. Califano and Suhail K. Mithani18 Sjogren's Syndrome 189Philip C. Fox19 Salivary Gland Dysfunction Associated with Systemic Disease 198Nelson L. Rhodus20 Progression and Treatment Evaluation in Diseases Affecting Salivary Glands 214Jiska M. Meijer, Cees G.M. Kallenberg, and Arjan Vissink21 The Uses of Saliva in Forensic Genetics 226Jack Ballantyne and Jane Juusola22 SPKB—Salivary Proteome Knowledge Base: A Platform for Collaborative Proteomics Research 233Weihong Yan, Weixia Yu, Shawn Than, Renli Qiao, D. Stott Parker, Joseph A. Loo, and David T. WongIII Saliva Diagnostics—A New Industry23 Commercialization of Oral Fluid Products and Technologies 243R. Sam Niedbala24 Coverage and Reimbursement for Salivary Diagnostic Tests 255James J. Crall25 Saliva Diagnostics in the Dentist's and Physician's Office 263Chakwan Siew and Milton V. Marshall26 Salivary Hormones in Research and Diagnostics 270Douglas A. Granger, Christine K. Fortunato, Leah C. Hibel27 Crossroads Between Saliva Diagnostics and Salivary Gland Gene Therapy 278Bruce J. Baum, Ana P. Cotrim, Corinne M. Goldsmith, Fumi Mineshiba, Senrong Qi, Gabor Z. Racz, Yuval Samuni, Takayuki Sugito, Antonis Voutetakis, and Changyu Zheng28 Saliva Diagnostics—A New Industry 288Stuart R. Smith, David T. Wong, and R. Michael BuchIndex 295

David Wong is Associate Dean of Research, Professor of Oral Biology, Oral Biology & Medicine, and Director of Dental Research Institute at UCLA. Dr. Wong is a dentist-scientist focusing his research on the molecular determinants (genomic and proteomic) of head and neck cancer. His research has been continuously funded by the NIDCR and NCI for the past 18 years. He has achieved two 4-year award U01 awards from the NIDCR for the creation of the UCLA Collaborative Oral Fluid Diagnostic Research Center and the Human Salivary Proteome project.

Select Guide Rating

• Contributors viiiForeword xvPreface xviiAcknowledgment xviiiI Background and Foundation1 Salivary Gland Development and Regeneration 3Sarah M. Knox and Matthew P. Hoffman2 Salivary Gland Physiology Relevant to Diagnostics 14Victor G. Romanenko and James E. Melvin3 Saliva: Properties and Functions 27Arie van Nieuw Amerongen, Enno C.I. Veerman, and Arjan Vissink4 Saliva Collectors 37Arjan Vissink, Andy Wolff, and Enno C.I. Veerman5 Salivary Secretion in Health and Disease 60Michael D. Turner and Jonathan A. Ship6 Processing and Storage of Saliva Samples 69Enno C.I. Veerman, Arjan Vissink, David T. Wong, and Arie van Nieuw AmerongenII Saliva Diagnostics7 Historical Perspectives and Present 79Frank G. Oppenheim8 Diagnostics Other Than Blood 94Sudhir Srivastava and Karl Krueger9 Perceptions of Saliva: Relevance to Clinical Diagnostics 104Sreenivas Koka and David T. Wong10 Saliva-Based Diagnostic Technologies: Highlights of the NIDCR's Program 111Eleni Kousvelari, John T. McDevitt, Daniel Malamud, David T. Wong, and David R. Walt11 Human Salivary Proteomics 122Shen Hu, Markus Hardt, Susan J. Fisher, David T. Wong, John R. Yates, James E. Melvin, and Joseph A. Loo12 Genomic Targets in Saliva 129Bernhard G. Zimmermann, Zhanzhi Hu, and David T. Wong13 Point-of-Care Diagnostics for Infectious diseases 136Paul L.A.M. Corstjens, Daniel Malamud14 Dental Caries Risk Assessment 150Paul C. Denny and Patricia A. Denny15 Periodontal Disease 156Christoph A. Ramseier, Thiago Morelli, Janet S. Kinney, Meghan Dubois, Lindsay Rayburn, and William Giannobile16 Role of Saliva in Detection of Substance Abuse 169Uttam Garg and Lance Presley17 Head and Neck Cancer 180Joseph A. Califano and Suhail K. Mithani18 Sjogren's Syndrome 189Philip C. Fox19 Salivary Gland Dysfunction Associated with Systemic Disease 198Nelson L. Rhodus20 Progression and Treatment Evaluation in Diseases Affecting Salivary Glands 214Jiska M. Meijer, Cees G.M. Kallenberg, and Arjan Vissink21 The Uses of Saliva in Forensic Genetics 226Jack Ballantyne and Jane Juusola22 SPKB—Salivary Proteome Knowledge Base: A Platform for Collaborative Proteomics Research 233Weihong Yan, Weixia Yu, Shawn Than, Renli Qiao, D. Stott Parker, Joseph A. Loo, and David T. WongIII Saliva Diagnostics—A New Industry23 Commercialization of Oral Fluid Products and Technologies 243R. Sam Niedbala24 Coverage and Reimbursement for Salivary Diagnostic Tests 255James J. Crall25 Saliva Diagnostics in the Dentist's and Physician's Office 263Chakwan Siew and Milton V. Marshall26 Salivary Hormones in Research and Diagnostics 270Douglas A. Granger, Christine K. Fortunato, Leah C. Hibel27 Crossroads Between Saliva Diagnostics and Salivary Gland Gene Therapy 278Bruce J. Baum, Ana P. Cotrim, Corinne M. Goldsmith, Fumi Mineshiba, Senrong Qi, Gabor Z. Racz, Yuval Samuni, Takayuki Sugito, Antonis Voutetakis, and Changyu Zheng28 Saliva Diagnostics—A New Industry 288Stuart R. Smith, David T. Wong, and R. Michael BuchIndex 295