"... an excellent primer on the molecular and biochemical underpinnings of disease. The author walks us through how the genome is structured and regulated, interspaced with detailed explanations of how changes in the genome result in biological function and human disease. He includes personal touches that help humanize the material, ..." - The Quarterly Review of Biology, 95(2)."Although the material is appropriate for advanced biology students, this volume would also be suitable for those with limited knowledge of biology due to the detailed and careful walkthrough of the topic matter that makes it approachable for nonspecialists, especially for fledgling computational biologists or clinical geneticists, and even for nonacademics who wish to better understand their own genome." - William Gillis, Biological Sciences, State University of New York College at Old Westbury

• 1. Introduction 2. A Molecular Disorder 3. A Code of Life 4. The Genome 5. Variants in the Human Genome Sequence and Their Biological Significance 6. The Critical Protein Coding Sequences 7. Triplet Repeats and Neurodegenerative Disorders 8. The Untranslated Parts of a Message 9. Exons, Introns, and a Royal Bleeding Disorder 10. The Regulation of Transcription 11. The Noncoding RNAs 12. Computational Methods Are Critical in the Analysis of Molecular Sequences 13. Diagnosing the Genome 14. Correcting Genome Errors 15. Epilogue Appendixes Glossary Recommended Textbooks for Further Reading Index

"... an excellent primer on the molecular and biochemical underpinnings of disease. The author walks us through how the genome is structured and regulated, interspaced with detailed explanations of how changes in the genome result in biological function and human disease. He includes personal touches that help humanize the material, ..." - The Quarterly Review of Biology, 95(2)."Although the material is appropriate for advanced biology students, this volume would also be suitable for those with limited knowledge of biology due to the detailed and careful walkthrough of the topic matter that makes it approachable for nonspecialists, especially for fledgling computational biologists or clinical geneticists, and even for nonacademics who wish to better understand their own genome." - William Gillis, Biological Sciences, State University of New York College at Old Westbury

• 1. Introduction 2. A Molecular Disorder 3. A Code of Life 4. The Genome 5. Variants in the Human Genome Sequence and Their Biological Significance 6. The Critical Protein Coding Sequences 7. Triplet Repeats and Neurodegenerative Disorders 8. The Untranslated Parts of a Message 9. Exons, Introns, and a Royal Bleeding Disorder 10. The Regulation of Transcription 11. The Noncoding RNAs 12. Computational Methods Are Critical in the Analysis of Molecular Sequences 13. Diagnosing the Genome 14. Correcting Genome Errors 15. Epilogue Appendixes Glossary Recommended Textbooks for Further Reading Index

"... an excellent primer on the molecular and biochemical underpinnings of disease. The author walks us through how the genome is structured and regulated, interspaced with detailed explanations of how changes in the genome result in biological function and human disease. He includes personal touches that help humanize the material, ..." - The Quarterly Review of Biology, 95(2)."Although the material is appropriate for advanced biology students, this volume would also be suitable for those with limited knowledge of biology due to the detailed and careful walkthrough of the topic matter that makes it approachable for nonspecialists, especially for fledgling computational biologists or clinical geneticists, and even for nonacademics who wish to better understand their own genome." - William Gillis, Biological Sciences, State University of New York College at Old Westbury

• 1. Introduction 2. A Molecular Disorder 3. A Code of Life 4. The Genome 5. Variants in the Human Genome Sequence and Their Biological Significance 6. The Critical Protein Coding Sequences 7. Triplet Repeats and Neurodegenerative Disorders 8. The Untranslated Parts of a Message 9. Exons, Introns, and a Royal Bleeding Disorder 10. The Regulation of Transcription 11. The Noncoding RNAs 12. Computational Methods Are Critical in the Analysis of Molecular Sequences 13. Diagnosing the Genome 14. Correcting Genome Errors 15. Epilogue Appendixes Glossary Recommended Textbooks for Further Reading Index