Taxol

Suffness\, Matthew

"...a marvelous job of assembling a cast of contributors who have excelled in bringing to full light the developmental hurdles a natural product can face en route to market and in highlighting the efforts and research strategies employed in attempts to surmount those barriers."-Dolatrai M. Vyas, J. Nat. Prod., 1996, 59, 216-218

• IntroductionDiscovery and Development of TAXOL®, M. Suffness and M.E. WallYew and Us: A Brief History of the Yew Tree. H.R. Hartzell, Jr.Supply of TAXOL®Taxus for TAXOL® and Taxoids, E.M. Croom, Jr.Potential of Plant Cell Culture for Taxane Production, D.M. Gibson, R.E.B. Ketchum, T.J. Hirasuna, and M.L. ShulerSemisynthesis of TAXOL® and Taxotere, R.A. Holton, R.J. Biediger, and P. Douglas BoatmanToward the Total Synthesis of TAXOL® and Its Analogues, P.A. Wender, M.G. Natchus, and A.J. ShukerBiology of TAXOL®Biosynthesis of TAXOL®, H.G. Floss and U. MocekPreclinical Antitumor Activity of Taxanes, W.C. RoseBiopharmaceutics of Paclitaxel (TAXOL®): Formulation, Activity, and Pharmacokinetics, R.M. StraubingerThe Use of TAXOL® in Cell Biology, R.B. ValleeChemistry of TAXOL®Detection and Isolation, K.M. SnaderNatural Taxoids: Structure and Chemistry, D.G.I. KingstonThe Medicinal Chemistry of TAXOL® , G.I. Georg, T.C. Boge, Z.S. Cheruvallath, J.S. Clowers, G.C.B. Harriman, M. Hepperie, and H. ParkClinical StudiesTAXOL® : Clinical Results and Current Issues in Development, S.G. Arbuck and B.A. BlaylockIndex