"Illuminating, authoritative, and forward looking, Glutamate and Addiction clarifies for the first time the relationship between glutamatergic systems and addiction investigations of many of today's emerging therapeutics for addictive disorders." -Biomedicine and Pharmacotherapy

• I. Introduction: Physiology and Pharmacology of Glutamate.- 1 Molecular Pharmacology and Physiology of Glutamate Receptors.- 2 Pharmacology of Glutamate Receptors.- 3 Glutamate and Neurotoxicity.- 4 Maturational Regulation of Glutamate Receptors and Their Role in Neuroplasticity.- 5 Role of the NMDA Receptor in Neuronal Apoptosis and HIV-Associated Dementia.- II. Glutamate: Stimulant Drugs of Abuse (Cocaine, Amphetamine, Methamphetamine).- 6 Role of Glutamate and Nitric Oxide in the Acquisition and Expression of Cocaine-Induced Conditioned Increases in Locomotor Activity.- 7 Interactions of Dopamine, Glutamate, and GABA Systems in Mediating Amphetamine- and Cocaine-Induced Stereotypy and Behavioral Sensitization.- 8 Addiction and Glutamate-Dependent Plasticity.- 9 Glutamate and Dopamine Interactions in the Motive Circuit: Implications for Craving.- 10 Glutamate Cascade from Metabotropic Glutamate Receptors to Gene Expression in Striatal Neurons: Implications for Psychostimulant Dependence and Medication.- 11 Glutamate Neurotransmission in the Course of Cocaine Addiction.- 12 Glutamate and the Self-Administration of Psychomotor-Stimulant Drugs.- 13 Roles of Glutamate, Nitric Oxide, Oxidative Stress, and Apoptosis in the Neurotoxicity of Methamphetamine.- 14 Methamphetamine Toxicity: Roles for Glutamate, Oxidative Processes, and Metabolic Stress.- 15 Nitric Oxide-Dependent Processes in the Action of Psychostimulants.- 16 Effects of Novel NMDA/Glycine-Site Antagonists on the Blockade of Cocaine-Induced Behavioral Toxicity in Mice.- 17 Clinical Studies Using NMDA Receptor Antagonists in Cocaine and Opioid Dependence.- 18 The Role of mGluR5 in the Effects of Cocaine: Implications for Medication Development.- III. Glutamate and Opiate Drugs (Heroin) of Abuse.- 19 Role of theGlutamatergic System in Opioid Tolerance and Dependence: Effects of NMDA Receptor Antagonists.- 20 The Role of NMDA Receptors in Opiate Tolerance, Sensitization, and Physical Dependence: A Review of the Research, A Cellular Model, and Implications for the Treatment of Pain and Addiction.- 21 Modification of Conditioned Reward by N-Methyl-D-aspartate Receptor Antagonists.- 22 Morphine Withdrawal as a State of Glutamate Hyperactivity: The Effects of Glutamate Receptor Subtype Ligands on Morphine Withdrawal Symptoms.- IV. Glutamate and Alcohol Abuse and Alcoholism.- 23 Alcohol Actions on Glutamate Receptors.- 24 Glutamate and Alcohol-Induced Neurotoxicity.- 25 Role of Glutamate in Alcohol Withdrawal Kindling.- 26 Alcohol and Glutamate Neurotransmission in Humans: Implications for Reward, Dependence, and Treatment.- 27 Mechanism of Action of Acamprosate Focusing on the Glutamatergic System.- 28 The NMDA/Nitric Oxide Synthase Cascade in Opioid Analgesia and Tolerance.- 29 Overview of Clinical Studies for Acamprosate.