Modern Therapeutics in Rheumatic Diseases

"It is indeed most helpful to those practicing Rheumatology. The author is a credible authority in the subject matter of the book...This book covers an exhaustive list of therapeutic topics. From familiar- such as Non Steroidal Drugs to unusual such as Apoptosis Regulation have been discussed in detail. Subjects such as Gene Therapy are especially well covered. The unique aspect of this book has to be its ability to discuss the latest knowledge in depth without losing sight of its primary objective; examining its clinical applicability...this book will prove to be of incomparable value; especially to practicing rheumatologists. It lays forth clearly what can be offered to the patient and why it may be of benefit when faced with the bewildering choices of therapeutic options available today. There are really no other books quite like it." -Doody's Health Sciences Book Review Journal "This book could not have been published at a better time from the rheumatology trainee's point of view. It is written in a coherent and concise manner, which serves as an excellent source for all aspects of therapeutics in the rheumatic diseases. Furthermore, the frequent use of diagrams and graphs allowed emphasis of key points. This publication links the basic science of rheumatic diseases to a comprehensive text of therapeutic mechanisms and efficacy." -The Journal of Rheumatology

• I. Rheumatoid Arthritis.- 1 New Treatment Opportunities for Rheumatoid Arthritis.- 2 Genetic Influences on Treatment Response in Rheumatoid Arthritis.- 3 Nonsteroidal Anti-Inflammatory Drugs in the Treatment of Rheumatoid Arthritis.- 4 Additional Considerations on the Use of Nonsteroidal Anti-Inflammatory Drugs.- 5 Glucocorticoid Therapy in Rheumatoid Arthritis.- 6 Anti-Tumor Necrosis Factor Agents.- 7 Interleukin-1 Receptor Antagonist Treatment in Rheumatoid Arthritis.- 8 Leflunomide: An Immunomodulatory Drug for the Treatment of Rheumatoid Arthritis.- 9 Matrix Metalloproteinase Inhibitors as Therapies for Rheumatoid Arthritis.- 10 Combination Disease-Modifying Anti-Rheumatic Drug (DMARD) Therapy.- 11 Experimental Therapeutics for Rheumatoid Arthritis.- II. Osteoarthritis.- 12 Slow-Acting Drugs for the Treatment of Osteoarthritis.- 13 Intra-Articular Therapy in Osteoarthritis.- 14 Promoting Articular Cartilage Repair.- 15 Using Molecular Markers to Monitor Osteoarthritis.- 16 New Therapeutic Targets for Osteoarthritis: The Rewards of Research.- 17 Recent Developments in the Therapy of Osteoarthritis.- III. Systemic Autoimmune Diseases.- 18 Treatment of Systemic Lupus Erythematosus.- 19 Treatment of the Antiphospholipid Syndrome.- 20 Treatment of Systemic Lupus Erythematosus by Blocking T-Cell Costimulation.- 21 Current Management of Systemic Sclerosis.- 22 Sjögren’s Syndrome.- 23 Mixed Connective Tissue Disease.- 24 Vasculitis.- 25 Treatment of Juvenile Rheumatoid Arthritis.- 26 Treatment of Inflammatory Myopathies.- 27 Psoriatic Arthritis.- 28 Complement Inhibitors in Rheumatic Diseases.- 29 Hematopoietic Stem Cell Transplantation of Autoimmune Disease.- IV. Gene Therapy in Rheumatic Diseases.- 30 Vectors for Gene Delivery.- 31 Gene Targeting of Cytokines and theMitogen-Activated Protein Kinase Pathways in Human Rheumatoid Synovium Using the Severe Combined Immunodeficiency Mouse Model.- 32 Retroviral Transduction of Antigen-Specific CD4+ T Cells for Local Delivery of Regulatory Molecules.- 33 Gene Transfer to Lymphocytes Targeting Cartilaginous Collagen Type II.- 34 Gene Therapy in Murine Arthritis: Cytokine-Directed Targeting.- 35 Modulation of the IKB Kinase/Nuclear Factor-KB Pathway by Gene Therapy.- 36 Regulation of Apoptosis in Rheumatoid Synoviocytes.- 37 Gene Therapy for Arthritis: Conception, Consolidation, and Clinical Trial.- V. Other Rheumatic Disorders.- 38 Recent Advances in the Pharmacotherapy of Spondyloarthropathies.- 39 Modern Therapy of Crystal Arthropathies.- 40 Treatment of Musculoskeletal Infections.