Jeffrey R. Strawn, MD is Professor of Psychiatry & Behavioral Neuroscience in the College of Medicine, University of Cincinnati, Cincinnati, Ohio. Stephen M. Stahl, MD is Adjunct Professor of Psychiatry at the University of California, San Diego, Clinical Professor of Psychiatry and Neuroscience at the University of California, Riverside, and Honorary Visiting Senior Fellow in Psychiatry at the University of Cambridge. He is also Clinical Professor of Psychiatry in Norton College of Medicine at Upstate Medical University.

'This collection of case studies is the most comprehensive and clinically relevant that I have ever read. As a practicing Child and Adolescent Psychiatrist, I have come face to face with many of the same clinical presentations and found Dr Strawn's review of the management thoughtful and integrative. It provides a unique framework for approaching these difficult interactions and offers a glimpse into how to combine science with the art of psychopharmacology when the evidence base is lacking. The emphasis on unique child and adolescent disorders, family dynamics and developmental pharmacology, outlines not just what the patient may need but also why. This is a must have for any Child and Adolescent Psychiatrist's library. I will certainly use it when teaching my residents and fellows and in my own practice as well.' Nicole M. Ballinger, DO, MPH, FAPA, Medical Staff President/Director, Child and Adolescent Psychiatry, Aurora Psychiatric Hospital, Wauwatosa, WI

• Introduction; List of icons; Abbreviations; 1. The case: the salutatorian who couldn't speak: Selective Serotonin Reuptake Inhibitor (SSRI)-refractory anxiety in an adolescent; 2. The case: from anxious to activated: Selective Serotonin Reuptake Inhibitor (SSRI)-related activation; 3. The case: the girl who couldn't sleep: Posttraumatic Stress Disorder (PTSD) in a young girl; 4. The case: depressed and still depressed: Major Depressive Disorder (MDD) in an adolescent; 5. The case: a 13-year-old adolescent who feels 'amazing': Selective Serotonin Reuptake Inhibitor (SSRI)-induced mania in an adolescent; 6. The case: counting on a cure: Obsessive–Compulsive Disorder (OCD) in an adolescent; 7. The case: struggles in the second grade: Attention-Deficit Hyperactivity Disorder (ADHD) in a child; 8. The case: from prodrome to psychosis: early-onset schizophrenia; 9. The case: too much, too little, or just right? lithium dosing in an adolescent; 10. The case: tic, tic, tic: motor and vocal tics in a boy; 11. The case: how slow can you go? Selective Serotonin Reuptake Inhibitor (SSRI) withdrawal and discontinuation in an adolescent; 12. The case: the adolescent who doesn't eat: anorexia nervosa in an adolescent; 13. The case: high or higher antidepressant concentrations? cannabis-related drug interactions in an adolescent; 14. The case: the boy whose bed was always wet: nocturnal enuresis in a child; 15. The case: counting sheep and counting treatment trials: insomnia disorder in an adolescent; 16. The case: Second-Generation Antipsychotics (SGAs), side effects, and the autism spectrum: SGA-related side effects in a boy with Autism Spectrum Disorder (ASD); 17. The case: the 'standard treatment' is earning a 'D': treatment-resistant schizophrenia; 18. The case: symptoms, side effects, or both? Selective Serotonin Reuptake Inhibitor (SSRI) tolerability and physical symptoms in an anxious adolescent; Index.

Jeffrey R. Strawn, MD is Professor of Psychiatry & Behavioral Neuroscience in the College of Medicine, University of Cincinnati, Cincinnati, Ohio. Stephen M. Stahl, MD is Adjunct Professor of Psychiatry at the University of California, San Diego, Clinical Professor of Psychiatry and Neuroscience at the University of California, Riverside, and Honorary Visiting Senior Fellow in Psychiatry at the University of Cambridge. He is also Clinical Professor of Psychiatry in Norton College of Medicine at Upstate Medical University.

'This collection of case studies is the most comprehensive and clinically relevant that I have ever read. As a practicing Child and Adolescent Psychiatrist, I have come face to face with many of the same clinical presentations and found Dr Strawn's review of the management thoughtful and integrative. It provides a unique framework for approaching these difficult interactions and offers a glimpse into how to combine science with the art of psychopharmacology when the evidence base is lacking. The emphasis on unique child and adolescent disorders, family dynamics and developmental pharmacology, outlines not just what the patient may need but also why. This is a must have for any Child and Adolescent Psychiatrist's library. I will certainly use it when teaching my residents and fellows and in my own practice as well.' Nicole M. Ballinger, DO, MPH, FAPA, Medical Staff President/Director, Child and Adolescent Psychiatry, Aurora Psychiatric Hospital, Wauwatosa, WI

• Introduction; List of icons; Abbreviations; 1. The case: the salutatorian who couldn't speak: Selective Serotonin Reuptake Inhibitor (SSRI)-refractory anxiety in an adolescent; 2. The case: from anxious to activated: Selective Serotonin Reuptake Inhibitor (SSRI)-related activation; 3. The case: the girl who couldn't sleep: Posttraumatic Stress Disorder (PTSD) in a young girl; 4. The case: depressed and still depressed: Major Depressive Disorder (MDD) in an adolescent; 5. The case: a 13-year-old adolescent who feels 'amazing': Selective Serotonin Reuptake Inhibitor (SSRI)-induced mania in an adolescent; 6. The case: counting on a cure: Obsessive–Compulsive Disorder (OCD) in an adolescent; 7. The case: struggles in the second grade: Attention-Deficit Hyperactivity Disorder (ADHD) in a child; 8. The case: from prodrome to psychosis: early-onset schizophrenia; 9. The case: too much, too little, or just right? lithium dosing in an adolescent; 10. The case: tic, tic, tic: motor and vocal tics in a boy; 11. The case: how slow can you go? Selective Serotonin Reuptake Inhibitor (SSRI) withdrawal and discontinuation in an adolescent; 12. The case: the adolescent who doesn't eat: anorexia nervosa in an adolescent; 13. The case: high or higher antidepressant concentrations? cannabis-related drug interactions in an adolescent; 14. The case: the boy whose bed was always wet: nocturnal enuresis in a child; 15. The case: counting sheep and counting treatment trials: insomnia disorder in an adolescent; 16. The case: Second-Generation Antipsychotics (SGAs), side effects, and the autism spectrum: SGA-related side effects in a boy with Autism Spectrum Disorder (ASD); 17. The case: the 'standard treatment' is earning a 'D': treatment-resistant schizophrenia; 18. The case: symptoms, side effects, or both? Selective Serotonin Reuptake Inhibitor (SSRI) tolerability and physical symptoms in an anxious adolescent; Index.

Jeffrey R. Strawn, MD is Professor of Psychiatry & Behavioral Neuroscience in the College of Medicine, University of Cincinnati, Cincinnati, Ohio. Stephen M. Stahl, MD is Adjunct Professor of Psychiatry at the University of California, San Diego, Clinical Professor of Psychiatry and Neuroscience at the University of California, Riverside, and Honorary Visiting Senior Fellow in Psychiatry at the University of Cambridge. He is also Clinical Professor of Psychiatry in Norton College of Medicine at Upstate Medical University.

'This collection of case studies is the most comprehensive and clinically relevant that I have ever read. As a practicing Child and Adolescent Psychiatrist, I have come face to face with many of the same clinical presentations and found Dr Strawn's review of the management thoughtful and integrative. It provides a unique framework for approaching these difficult interactions and offers a glimpse into how to combine science with the art of psychopharmacology when the evidence base is lacking. The emphasis on unique child and adolescent disorders, family dynamics and developmental pharmacology, outlines not just what the patient may need but also why. This is a must have for any Child and Adolescent Psychiatrist's library. I will certainly use it when teaching my residents and fellows and in my own practice as well.' Nicole M. Ballinger, DO, MPH, FAPA, Medical Staff President/Director, Child and Adolescent Psychiatry, Aurora Psychiatric Hospital, Wauwatosa, WI

• Introduction; List of icons; Abbreviations; 1. The case: the salutatorian who couldn't speak: Selective Serotonin Reuptake Inhibitor (SSRI)-refractory anxiety in an adolescent; 2. The case: from anxious to activated: Selective Serotonin Reuptake Inhibitor (SSRI)-related activation; 3. The case: the girl who couldn't sleep: Posttraumatic Stress Disorder (PTSD) in a young girl; 4. The case: depressed and still depressed: Major Depressive Disorder (MDD) in an adolescent; 5. The case: a 13-year-old adolescent who feels 'amazing': Selective Serotonin Reuptake Inhibitor (SSRI)-induced mania in an adolescent; 6. The case: counting on a cure: Obsessive–Compulsive Disorder (OCD) in an adolescent; 7. The case: struggles in the second grade: Attention-Deficit Hyperactivity Disorder (ADHD) in a child; 8. The case: from prodrome to psychosis: early-onset schizophrenia; 9. The case: too much, too little, or just right? lithium dosing in an adolescent; 10. The case: tic, tic, tic: motor and vocal tics in a boy; 11. The case: how slow can you go? Selective Serotonin Reuptake Inhibitor (SSRI) withdrawal and discontinuation in an adolescent; 12. The case: the adolescent who doesn't eat: anorexia nervosa in an adolescent; 13. The case: high or higher antidepressant concentrations? cannabis-related drug interactions in an adolescent; 14. The case: the boy whose bed was always wet: nocturnal enuresis in a child; 15. The case: counting sheep and counting treatment trials: insomnia disorder in an adolescent; 16. The case: Second-Generation Antipsychotics (SGAs), side effects, and the autism spectrum: SGA-related side effects in a boy with Autism Spectrum Disorder (ASD); 17. The case: the 'standard treatment' is earning a 'D': treatment-resistant schizophrenia; 18. The case: symptoms, side effects, or both? Selective Serotonin Reuptake Inhibitor (SSRI) tolerability and physical symptoms in an anxious adolescent; Index.