Robert D. Stevens is Associate Professor, Department of Anesthesiology and Critical Care Medicine and Associate Professor of Neurology, Neurosurgery and Radiology-Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Tarek Sharshar is Professor, Department of Intensive Care Medicine, Raymond Poincaré Hospital, University Versailles Saint-Quentin en Yvelines, Garches, France. E. Wesley Ely is Professor of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine and Vanderbilt University Medical Center, Nashville, Tennessee, USA.

'The chapters are concise, well written, and well organized … This very strong and well-referenced basic science text covers a broad range of topics including neuroanatomy, neurophysiology, and biochemistry, and delivers a solid foundation that clinicians can translate to an increased understanding of brain dysfunction at bedside.' Canadian Journal of Anesthesia

• Foreword; Introduction; Glossary; Part I. Epidemiology and Outcomes: 1. The epidemiology of critical illness brain dysfunction; 2. Cognitive dysfunction following critical illness; 3. Psychiatric disorders following critical illnesses; 4. Functional status and quality of life after critical illness; 5. Delirium and dementia: unraveling the complex relationship; Part II. Behavioral Neurology in the ICU: 6. Cognitive reserve; 7. Neurology of consciousness impairments; 8. Mechanisms of attention and attentional impairment; 9. Neurology of sleep and sleep disorders; 10. Neural basis of fear and anxiety; Part III. Biological Mechanisms: 11. Experimental models of cognitive dysfunction in infection and critical illness; 12. Neurobiological effects of systemic physiological and metabolic insults; 13. Cerebral ischemia and reperfusion; 14. Brain perfusion and autoregulation in systemic critical illness; 15. Delirium and neurotransmitter dysfunction; 16. Neuromodulatory and neurotoxic effects of sedative agents; 17. Neuroimmunological crosstalk in critical illness; 18. Inflammatory mechanisms in chronic neurodegenerative disease: the impact of microglia priming; 19. The neuroendocrine response to critical illness; 20. Autonomic dysfunction in SIRS and sepsis; 21. Sepsis-induced neuronal dysfunction and death; 22. Neuroimmunomodulation in sepsis; Part IV. Diagnosis of Brain Dysfunction: 23. Clinical neurological assessment of the critically ill patient; 24. Bedside assessment of delirium in critically ill patients; 25. Electroencephalography and evoked potentials in critically ill patients; 26. Neuroimaging of delirium; Part V. Preventative and Therapeutic Interventions: 27. Environmental modification; 28. New paradigms in sedation of the critically ill patient; 29. Pharmacological management of delirium; 30. Pharmacogenomics and cerebral dysfunction; 31. Early physical and occupational therapy; 32. Rehabilitation after critical illness; Part VI. Clinical Encephalopathy Syndromes: 33. Drug-induced encephalopathy; 34. Metabolic encephalopathies: inborn errors of metabolism causing encephalopathies in adults; 35. Encephalopathy associated with alcohol or drug withdrawal; 36. Posterior reversible encephalopathy syndrome (PRES): the essential elements; 37. Hypoxic ischemic encephalopathy; 38. Sepsis-associated encephalopathy; 39. Seizures and status epilepticus in critical illness; 40. Encephalopathy and coma in acute liver failure and chronic liver failure; 41. Neurologic complications of cardiac surgery: stroke, encephalopathy, and cognitive decline; Index.

Robert D. Stevens is Associate Professor, Department of Anesthesiology and Critical Care Medicine and Associate Professor of Neurology, Neurosurgery and Radiology-Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Tarek Sharshar is Professor, Department of Intensive Care Medicine, Raymond Poincaré Hospital, University Versailles Saint-Quentin en Yvelines, Garches, France. E. Wesley Ely is Professor of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine and Vanderbilt University Medical Center, Nashville, Tennessee, USA.

'The chapters are concise, well written, and well organized … This very strong and well-referenced basic science text covers a broad range of topics including neuroanatomy, neurophysiology, and biochemistry, and delivers a solid foundation that clinicians can translate to an increased understanding of brain dysfunction at bedside.' Canadian Journal of Anesthesia

• Foreword; Introduction; Glossary; Part I. Epidemiology and Outcomes: 1. The epidemiology of critical illness brain dysfunction; 2. Cognitive dysfunction following critical illness; 3. Psychiatric disorders following critical illnesses; 4. Functional status and quality of life after critical illness; 5. Delirium and dementia: unraveling the complex relationship; Part II. Behavioral Neurology in the ICU: 6. Cognitive reserve; 7. Neurology of consciousness impairments; 8. Mechanisms of attention and attentional impairment; 9. Neurology of sleep and sleep disorders; 10. Neural basis of fear and anxiety; Part III. Biological Mechanisms: 11. Experimental models of cognitive dysfunction in infection and critical illness; 12. Neurobiological effects of systemic physiological and metabolic insults; 13. Cerebral ischemia and reperfusion; 14. Brain perfusion and autoregulation in systemic critical illness; 15. Delirium and neurotransmitter dysfunction; 16. Neuromodulatory and neurotoxic effects of sedative agents; 17. Neuroimmunological crosstalk in critical illness; 18. Inflammatory mechanisms in chronic neurodegenerative disease: the impact of microglia priming; 19. The neuroendocrine response to critical illness; 20. Autonomic dysfunction in SIRS and sepsis; 21. Sepsis-induced neuronal dysfunction and death; 22. Neuroimmunomodulation in sepsis; Part IV. Diagnosis of Brain Dysfunction: 23. Clinical neurological assessment of the critically ill patient; 24. Bedside assessment of delirium in critically ill patients; 25. Electroencephalography and evoked potentials in critically ill patients; 26. Neuroimaging of delirium; Part V. Preventative and Therapeutic Interventions: 27. Environmental modification; 28. New paradigms in sedation of the critically ill patient; 29. Pharmacological management of delirium; 30. Pharmacogenomics and cerebral dysfunction; 31. Early physical and occupational therapy; 32. Rehabilitation after critical illness; Part VI. Clinical Encephalopathy Syndromes: 33. Drug-induced encephalopathy; 34. Metabolic encephalopathies: inborn errors of metabolism causing encephalopathies in adults; 35. Encephalopathy associated with alcohol or drug withdrawal; 36. Posterior reversible encephalopathy syndrome (PRES): the essential elements; 37. Hypoxic ischemic encephalopathy; 38. Sepsis-associated encephalopathy; 39. Seizures and status epilepticus in critical illness; 40. Encephalopathy and coma in acute liver failure and chronic liver failure; 41. Neurologic complications of cardiac surgery: stroke, encephalopathy, and cognitive decline; Index.

Robert D. Stevens is Associate Professor, Department of Anesthesiology and Critical Care Medicine and Associate Professor of Neurology, Neurosurgery and Radiology-Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Tarek Sharshar is Professor, Department of Intensive Care Medicine, Raymond Poincaré Hospital, University Versailles Saint-Quentin en Yvelines, Garches, France. E. Wesley Ely is Professor of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine and Vanderbilt University Medical Center, Nashville, Tennessee, USA.

'The chapters are concise, well written, and well organized … This very strong and well-referenced basic science text covers a broad range of topics including neuroanatomy, neurophysiology, and biochemistry, and delivers a solid foundation that clinicians can translate to an increased understanding of brain dysfunction at bedside.' Canadian Journal of Anesthesia

• Foreword; Introduction; Glossary; Part I. Epidemiology and Outcomes: 1. The epidemiology of critical illness brain dysfunction; 2. Cognitive dysfunction following critical illness; 3. Psychiatric disorders following critical illnesses; 4. Functional status and quality of life after critical illness; 5. Delirium and dementia: unraveling the complex relationship; Part II. Behavioral Neurology in the ICU: 6. Cognitive reserve; 7. Neurology of consciousness impairments; 8. Mechanisms of attention and attentional impairment; 9. Neurology of sleep and sleep disorders; 10. Neural basis of fear and anxiety; Part III. Biological Mechanisms: 11. Experimental models of cognitive dysfunction in infection and critical illness; 12. Neurobiological effects of systemic physiological and metabolic insults; 13. Cerebral ischemia and reperfusion; 14. Brain perfusion and autoregulation in systemic critical illness; 15. Delirium and neurotransmitter dysfunction; 16. Neuromodulatory and neurotoxic effects of sedative agents; 17. Neuroimmunological crosstalk in critical illness; 18. Inflammatory mechanisms in chronic neurodegenerative disease: the impact of microglia priming; 19. The neuroendocrine response to critical illness; 20. Autonomic dysfunction in SIRS and sepsis; 21. Sepsis-induced neuronal dysfunction and death; 22. Neuroimmunomodulation in sepsis; Part IV. Diagnosis of Brain Dysfunction: 23. Clinical neurological assessment of the critically ill patient; 24. Bedside assessment of delirium in critically ill patients; 25. Electroencephalography and evoked potentials in critically ill patients; 26. Neuroimaging of delirium; Part V. Preventative and Therapeutic Interventions: 27. Environmental modification; 28. New paradigms in sedation of the critically ill patient; 29. Pharmacological management of delirium; 30. Pharmacogenomics and cerebral dysfunction; 31. Early physical and occupational therapy; 32. Rehabilitation after critical illness; Part VI. Clinical Encephalopathy Syndromes: 33. Drug-induced encephalopathy; 34. Metabolic encephalopathies: inborn errors of metabolism causing encephalopathies in adults; 35. Encephalopathy associated with alcohol or drug withdrawal; 36. Posterior reversible encephalopathy syndrome (PRES): the essential elements; 37. Hypoxic ischemic encephalopathy; 38. Sepsis-associated encephalopathy; 39. Seizures and status epilepticus in critical illness; 40. Encephalopathy and coma in acute liver failure and chronic liver failure; 41. Neurologic complications of cardiac surgery: stroke, encephalopathy, and cognitive decline; Index.