Encyclopedia of Drug Metabolism and Interactions, Absorption, Distribution, Metabolism, and Excretion (ADME) of Drugs

ALEXANDER V. LYUBIMOV, MD, PhD, DABT, is Director of the Toxicology Research Laboratory and Associate Professor of Pharmacology at the University of Illinois at Chicago. He has more than thirty years of experience in the fields of toxicology, bioanalytical chemistry, and drug efficacy. He has presented his research results at more than fifty national and international scientific conferences. In addition, he has published more than 140 scientific publications in peer-reviewed journals, books, and conference proceedings. Dr. Lyubimov has served as chair or president of several international conferences, including "Frontiers of Pharmacology and Toxicology," which he also organized.

• Contributors xiPreface to the Encyclopedia xxvPreface—Volume 2 xxixPART III General Principles of ADME. Drug Transporters and Other Mechanisms of Transport 11 ADME Profiling in Drug Discovery and Development: An Overview 3Tonika Bohnert and Chandra Prakash2 Anatomical and Physiological Parameters that Influence Gastrointestinal Absorption 45John M. DeSesso, Catherine F. Jacobson, and Amy Lavin Williams3 Oral Absorption: from Physiology to Regulatory 81Fran Berlioz-Seux4 General Principles of Drug Distribution 107Gillian C. Wallace, Diane B. Ramsden, and M. Helen Grant5 ABC Drug Transporters and Their Impact on Drug Disposition/Drug Sensitivity and Resistance 155Steven J. Wolf and Caroline G. Lee6 Solute Carrier (SLC) Family Transporters 195Jasminder Sahi, Yurong Lai, and Caroline Lee7 Mechanisms of Drug Metabolism 247Robert S. Foti, Dan A. Rock, Larry C. Wienkers, and Jan L. Wahlstrom8 Extrahepatic Drug-Metabolizing Enzymes and Their Significance 315Shalu Jhajra, Ninad Ramesh Varkhede, Deepak Suresh Ahire, Bukke Vidyasagar Naik, Bhagwat Prasad, Jyoti Paliwal, and Saranjit Singh9 Mass Balance Studies in Animals and Humans 415Tsuhan Lin, Tycho Heimbach, Rakesh Gollen, and Handan He10 Bioavailability and Bioequivalence 455Benny M. Amore11 Interspecies Pharmacokinetic Scaling and the Prediction of Human Pharmacokinetics Using Animal and Cell Models 495Meihua Rose Feng, Nan Zheng, Xinyuan Zhang, Yea Min Huh, and Jing-yu Yu12 The Significance and Determination of Plasma Protein Binding 531Anagha A. Damre and Krishna R. Iyer13 Excretion Systems 549Kazuya Maeda and Yuichi Sugiyama14 Pharmacokinetics and Toxicokinetics in Drug Discovery and Development 581Manthena V. S. Varma, Zaher A. Radi, Charles J. Rotter, John Litchfield, and Ayman F. El-Kattan15 Pharmacokinetic Data Analysis and Modeling of ADME Processes 599Steven Zhang16 Physiologically Based Pharmacokinetic (PBPK) Modeling: Usefulness and Applications 637Han-Joo Maeng, Edwin C. Y. Chow, Jianghong Fan, and K. Sandy Pang17 Pharmacodynamics 685Indranil Rao, Vinay HK, and Sandhya Mandlekar18 Translational Drug Discovery Research: Integration of Medicinal Chemistry, Computational Modeling, Pharmacology, ADME, and Toxicology 737Subrahmanyam Vangala, Jakir Pinjari, Prashant Patole, Selvan Ravindran, Rajeev Gangal, Pralhad Wangikar, Sudipta Basu, Tausif Ahmed, and Himanshu RastogiPART IV ADME of Some Specific Groups of Drugs and Delivery Systems 79119 ADME of Herbal Dietary Supplements 793Sheela PaiBir and Sadayappan V. Rahavendran20 ADME of Anticancer Drugs 841Hiroshi Yamazaki21 ADME of Cardiovascular Drugs 855Hong Liu and Richard Voorman22 Disposition of Biological Therapeutics: Monoclonal Antibodies, Proteins, and Peptides 895Dan A. Rock, Larry C. Wienkers, and Marc W. Retter23 ADME of Natural Toxins 917Vanessa González-Pérez and David J. Kroll24 Influence of Changes in Physiology, Transporters, and Enzyme Expression on Disposition and Metabolism of Drugs during Pregnancy and Clinical Implications 933Shalu Jhajra, Saranjit Singh, Karsten A. Holm, Ali Said Faqi, and Jasminder SahiIndex 963