RAMON RIOS TORRES, PhD, is Reader in Organic Chemistry at the University of Southampton. With more than ninety peer-reviewed articles and several book chapters to his credit, Dr. Rios Torres devotes his research to the development of new asymmetric methods based on organocatalysis and organometallic chemistry as well as the application of these methods in total synthesis. Dr. Rios Torres is also the editor of The Pauson-Khand Reaction: Scope, Variations and Applications (Wiley).

“The book is nicely structured and the chapters are extensively supplemented by references, offering the reader a practical overview of the field of asymmetric organocatalysis . . . Congratulations to the editor and to all the authors for this nice piece of work.”  (Angew. Chem. Int. Ed, 1 October 2014)

• PREFACE viiCONTRIBUTORS ix1. INTRODUCTION: A HISTORICAL POINT OF VIEW 1Ramon Rios and Xavier Companyó2. ACTIVATION MODES IN ASYMMETRIC ORGANOCATALYSIS 11Albert Moyano3. C–C BOND FORMATION BY ALDOL REACTION 81Dorota Gryko and Dominika Walaszek4. EXAMPLES OF METAL-FREE DIRECT CATALYTIC ASYMMETRIC MANNICH-TYPE REACTIONS USING AMINOCATALYSIS 129Armando Córdova5. C–C BOND FORMATION BY MICHAEL REACTION 147Yong Zhang and Wei Wang6. C–C BOND FORMATION BY DIELS–ALDER AND OTHER PERICYCLIC REACTIONS 205Johan Franzén7. N-HETEROCYCLIC CARBENE-CATALYZED C–C BOND FORMATION 231Xiang-Yu Chen and Song Ye8. a-ALKYLATION OF CARBONYL COMPOUNDS 267Marek Remeš and Jan Veselý9. OTHER REACTIONS FOR C–C BOND FORMATION 313Yi-Xia Jia and Tiexin Zhang10. CASCADE REACTIONS FORMING C–C BONDS 351Ramon Rios, Jorge Esteban, and Xavier Companyó11. ORGANOCATALYTIC C–N BOND FORMATION 381Aitor Landa, Rosa López, Antonia Mielgo, Mikel Oiarbide, and Claudio Palomo12. C–O BOND FORMATION 433José Alemán and Mariola Tortosa13. CARBON–HALOGEN BOND FORMATION 465Stacey E. Brenner-Moyer14. C–OTHER ATOM BOND FORMATION (S, SE, B) 493Giorgio Della Sala and Alessandra Lattanzi15. ENANTIOSELECTIVE ORGANOCATALYTIC REDUCTIONS 529Maurizio Benaglia, Martina Bonsignore, and Andrea Genoni16. CASCADE REACTIONS FORMING BOTH C–C BOND AND C–HETEROATOM BOND 559Damien Bonne, Thierry Constantieux, Yoann Coquerel, and Jean Rodriguez17. ORGANOCATALYSIS IN THE SYNTHESIS OF NATURAL PRODUCTS 587Yongcheng Ying and Xuefeng JiangINDEX 629

RAMON RIOS TORRES, PhD, is Reader in Organic Chemistry at the University of Southampton. With more than ninety peer-reviewed articles and several book chapters to his credit, Dr. Rios Torres devotes his research to the development of new asymmetric methods based on organocatalysis and organometallic chemistry as well as the application of these methods in total synthesis. Dr. Rios Torres is also the editor of The Pauson-Khand Reaction: Scope, Variations and Applications (Wiley).

“The book is nicely structured and the chapters are extensively supplemented by references, offering the reader a practical overview of the field of asymmetric organocatalysis . . . Congratulations to the editor and to all the authors for this nice piece of work.”  (Angew. Chem. Int. Ed, 1 October 2014)

• PREFACE viiCONTRIBUTORS ix1. INTRODUCTION: A HISTORICAL POINT OF VIEW 1Ramon Rios and Xavier Companyó2. ACTIVATION MODES IN ASYMMETRIC ORGANOCATALYSIS 11Albert Moyano3. C–C BOND FORMATION BY ALDOL REACTION 81Dorota Gryko and Dominika Walaszek4. EXAMPLES OF METAL-FREE DIRECT CATALYTIC ASYMMETRIC MANNICH-TYPE REACTIONS USING AMINOCATALYSIS 129Armando Córdova5. C–C BOND FORMATION BY MICHAEL REACTION 147Yong Zhang and Wei Wang6. C–C BOND FORMATION BY DIELS–ALDER AND OTHER PERICYCLIC REACTIONS 205Johan Franzén7. N-HETEROCYCLIC CARBENE-CATALYZED C–C BOND FORMATION 231Xiang-Yu Chen and Song Ye8. a-ALKYLATION OF CARBONYL COMPOUNDS 267Marek Remeš and Jan Veselý9. OTHER REACTIONS FOR C–C BOND FORMATION 313Yi-Xia Jia and Tiexin Zhang10. CASCADE REACTIONS FORMING C–C BONDS 351Ramon Rios, Jorge Esteban, and Xavier Companyó11. ORGANOCATALYTIC C–N BOND FORMATION 381Aitor Landa, Rosa López, Antonia Mielgo, Mikel Oiarbide, and Claudio Palomo12. C–O BOND FORMATION 433José Alemán and Mariola Tortosa13. CARBON–HALOGEN BOND FORMATION 465Stacey E. Brenner-Moyer14. C–OTHER ATOM BOND FORMATION (S, SE, B) 493Giorgio Della Sala and Alessandra Lattanzi15. ENANTIOSELECTIVE ORGANOCATALYTIC REDUCTIONS 529Maurizio Benaglia, Martina Bonsignore, and Andrea Genoni16. CASCADE REACTIONS FORMING BOTH C–C BOND AND C–HETEROATOM BOND 559Damien Bonne, Thierry Constantieux, Yoann Coquerel, and Jean Rodriguez17. ORGANOCATALYSIS IN THE SYNTHESIS OF NATURAL PRODUCTS 587Yongcheng Ying and Xuefeng JiangINDEX 629

RAMON RIOS TORRES, PhD, is Reader in Organic Chemistry at the University of Southampton. With more than ninety peer-reviewed articles and several book chapters to his credit, Dr. Rios Torres devotes his research to the development of new asymmetric methods based on organocatalysis and organometallic chemistry as well as the application of these methods in total synthesis. Dr. Rios Torres is also the editor of The Pauson-Khand Reaction: Scope, Variations and Applications (Wiley).

“The book is nicely structured and the chapters are extensively supplemented by references, offering the reader a practical overview of the field of asymmetric organocatalysis . . . Congratulations to the editor and to all the authors for this nice piece of work.”  (Angew. Chem. Int. Ed, 1 October 2014)

• PREFACE viiCONTRIBUTORS ix1. INTRODUCTION: A HISTORICAL POINT OF VIEW 1Ramon Rios and Xavier Companyó2. ACTIVATION MODES IN ASYMMETRIC ORGANOCATALYSIS 11Albert Moyano3. C–C BOND FORMATION BY ALDOL REACTION 81Dorota Gryko and Dominika Walaszek4. EXAMPLES OF METAL-FREE DIRECT CATALYTIC ASYMMETRIC MANNICH-TYPE REACTIONS USING AMINOCATALYSIS 129Armando Córdova5. C–C BOND FORMATION BY MICHAEL REACTION 147Yong Zhang and Wei Wang6. C–C BOND FORMATION BY DIELS–ALDER AND OTHER PERICYCLIC REACTIONS 205Johan Franzén7. N-HETEROCYCLIC CARBENE-CATALYZED C–C BOND FORMATION 231Xiang-Yu Chen and Song Ye8. a-ALKYLATION OF CARBONYL COMPOUNDS 267Marek Remeš and Jan Veselý9. OTHER REACTIONS FOR C–C BOND FORMATION 313Yi-Xia Jia and Tiexin Zhang10. CASCADE REACTIONS FORMING C–C BONDS 351Ramon Rios, Jorge Esteban, and Xavier Companyó11. ORGANOCATALYTIC C–N BOND FORMATION 381Aitor Landa, Rosa López, Antonia Mielgo, Mikel Oiarbide, and Claudio Palomo12. C–O BOND FORMATION 433José Alemán and Mariola Tortosa13. CARBON–HALOGEN BOND FORMATION 465Stacey E. Brenner-Moyer14. C–OTHER ATOM BOND FORMATION (S, SE, B) 493Giorgio Della Sala and Alessandra Lattanzi15. ENANTIOSELECTIVE ORGANOCATALYTIC REDUCTIONS 529Maurizio Benaglia, Martina Bonsignore, and Andrea Genoni16. CASCADE REACTIONS FORMING BOTH C–C BOND AND C–HETEROATOM BOND 559Damien Bonne, Thierry Constantieux, Yoann Coquerel, and Jean Rodriguez17. ORGANOCATALYSIS IN THE SYNTHESIS OF NATURAL PRODUCTS 587Yongcheng Ying and Xuefeng JiangINDEX 629