M. Julia B. Felippe, MedVet, MSc, PhD, DACVIM, is an Associate Professor of Large Animal Medicine and Veterinary Curriculum Director at Cornell University’s College of Veterinary Medicine in Ithaca, New York, USA.

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• Contributors, ixPreface, xi1 The Immune System, 1M. Julia B. Felippe1.1 Definition, 11.2 The organs of the immune system, 11.3 The immune cells and soluble molecules, 21.4 B and T cell activation in lymphoid tissues, 61.5 When the immune response goes wrong, 9References, 102 The Immune System of the Young Horse, 11Rebecca L. Tallmadge2.1 Definition, 112.2 Equine immune system development, 112.3 Unique susceptibilities and disorders of young horses, 162.4 Vaccinology teaches about neonatal immunity, 18References, 183 The Immune System of the Older Horse, 23Amanda A. Adams and David W. Horohov3.1 Definition, 233.2 Clinical conditions associated with aging, 233.3 Immunosenescence and vaccination, 233.4 Nutrition in enhancing immunity in the old horse, 263.5 Conclusion, 27References, 274 Anaphylaxis, 31Rolfe M. Radcliffe4.1 Definition, 314.2 Signalment and clinical signs, 314.3 Immunologic mechanisms and etiologic associations, 324.4 Diagnostics, 334.5 Treatment, 344.6 Prevention, 364.7 Prognosis and clinical outcomes, 37References, 375 Allergy, 39Bettina Wagner5.1 Definition, 395.2 Culicoides hypersensitivity, 395.3 Urticaria, 435.4 Recurrent airway obstruction, 44References, 446 Immune-Mediated Cytopenias, 47Thomas J. Divers6.1 Definition, 476.2 Immune-mediated hemolytic anemia, 476.3 Immune-mediated thrombocytopenia, 506.4 Immune-mediated neutropenia, 53References, 547 Bullous Diseases of the Skin and Mucosa, 55Jeanine Peters-Kennedy and Rebecca E. Ruby7.1 Definition, 557.2 Immune-mediated bullous dermatoses, 557.3 Pemphigus complex, 577.4 Cutaneous adverse drug reactions, 617.5 Erythema multiforme, 627.6 Lupus erythematosus, 64References, 658 Serum Sickness, 69Lais R.R. Costa8.1 Definition, 698.2 Signalment and clinical signs, 698.3 Immunologic mechanisms and etiologic associations, 698.4 Diagnostics, 718.5 Treatment and prevention, 71References, 729 Vasculitis, 73James S. W. Prutton and Nicola Pusterla9.1 Definition, 739.2 Signalment and clinical signs, 739.3 Immunologic mechanisms and etiologic associations, 739.4 Diagnostics, 759.5 Treatment, 759.6 Thrombophlebitis, 759.7 Pastern and cannon leukocytoclastic vasculitis, 769.8 Drug-induced vasculitis, 769.9 Photo-activated vasculitis (photodynamic drugs), 779.10 Strongylus vulgaris, 779.11 Equine granulocytic anaplasmosis, 779.12 Equine viral arteritis, 789.13 Equine herpesvirus-1, 789.14 African horse sickness, 78References, 7910 Purpura Hemorrhagica, 83Laszlo M. Hunyadi and Nicola Pusterla10.1 Definition, 8310.2 Signalment and clinical signs, 8310.3 Immunologic mechanisms and etiologic associations, 8310.4 Diagnostics, 8410.5 Treatment and prevention, 85References, 8611 Glomerulonephritis, 87M. Julia B. Felippe11.1 Definition, 8711.2 Signalment and clinical signs, 8711.3 Immunologic mechanisms and etiologic associations, 8711.4 Diagnostics, 8811.5 Treatment and prognosis, 88References, 8812 Inflammatory and Immune-Mediated Muscle Disorders, 91Sian Durward-Akhurst and Stephanie J. Valberg12.1 Definition, 9112.2 Infarctive purpura hemorrhagica, 9112.3 Rhabdomyolysis associated with Streptococcus equi, 9312.4 Immune-mediated myositis in Quarter Horse-related breeds, 9412.5 Systemic calcinosis, 9612.6 Uncharacterized immune-mediated and inflammatory myopathies, 9712.7 Sarcocystis myositis, 97References, 9813 Granulomatous Diseases, 101Lais R.R. Costa13.1 Definition, 10113.2 Signalment and clinical signs, 10113.3 Immunologic mechanisms and etiologic associations, 10113.4 Diagnostics, 10413.5 Treatment and prevention, 10513.6 Types of cell-mediated hypersensitivity reactions, 105References, 11014 Chronic Inflammatory Bowel Disease, 113Gillian A. Perkins14.1 Definition, 11314.2 Signalment and clinical signs, 11314.3 Immunologic mechanisms and etiologic associations, 11314.4 Diagnostics, 11514.5 Treatment and prognosis, 116References, 11715 Recurrent Uveitis, 121Brian C. Gilger15.1 Definition, 12115.2 Signalment and clinical signs, 12115.3 Immunologic mechanisms and etiologic associations, 12115.4 Diagnostics, 12315.5 Treatment and prevention, 12415.6 Prognosis and clinical outcomes, 124References, 12516 Recurrent Airway Obstruction and Summer Pasture-Associated Obstructive Pulmonary Disease, 127Michela Bullone and Jean-Pierre Lavoie16.1 Definition, 12716.2 Signalment and clinical signs, 12716.3 Immunologic mechanisms and etiologic associations, 12816.4 Diagnostics, 13416.5 Treatments and prevention, 136References, 13717 Inflammatory Airway Disease, 145Mathilde Leclère and Jean-Pierre Lavoie17.1 Definition, 14517.2 Signalment and clinical signs, 14517.3 Immunologic mechanisms and etiologic associations, 14517.4 Types of bronchoalveolar lavage fluid inflammation and cytokine profile, 14717.5 Links between IAD and heaves, 14817.6 Links between IAD and EIPH, 14817.7 Diagnostics, 14817.8 Treatment and prevention, 14917.9 Prognosis and clinical outcomes, 150References, 15018 Inflammation, Endotoxemia and Systemic Inflammatory Response Syndrome, 153Erin L. McConachie and Kelsey A. Hart18.1 Definition, 15318.2 Signalment and clinical signs, 15418.3 Immunologic mechanisms and etiologic associations, 15518.4 Multi-systemic response triggered by inflammatory mediators, 15718.5 Diagnostics, 16018.6 Treatment, 16218.7 Prognosis and clinical outcome, 166References, 16619 Leukemia, 173Tracy Stokol19.1 Definition, 17319.2 Classification of leukemias, 17319.3 Specialized diagnostic techniques for leukemia, 17319.4 Chronic leukemia, 17519.5 Acute leukemia, 177References, 17920 Lymphoma, 181SallyAnne L. Ness20.1 Definition, 18120.2 Signalment and clinical signs, 18120.3 Forms of equine lymphoma, 18220.4 Immunologic mechanisms and etiologic associations, 18320.5 Diagnostics, 18320.6 Classification of lymphomas, 18520.7 Prognosis and treatment, 18620.8 Monitoring, 189References, 18921 Immunodeficiencies, 193M. Julia B. Felippe21.1 Definition, 19321.2 Classification of immunodeficiencies, 194References, 20222 Immunologic Testing, 205M. Julia B. Felippe22.1 Definition, 20522.2 Types of immunologic testing, 205References, 21123 Non-steroidal Anti-inflammatories, 213Michelle H. Barton23.1 Definition, 21323.2 Non-steroidal anti-inflammatory drugs, 213References, 22824 Immunosuppressive Therapy, 237M. Julia B. Felippe24.1 Definition, 23724.2 Types of immunosuppressive drugs, 237References, 24025 Immunomodulators, 243Elizabeth G. Davis25.1 Definition, 24325.2 Immunologic mechanisms, 24325.3 Commercially available immunostimulants for use in horses, 244References, 24926 Immunoglobulin Therapy, 251Elizabeth G. Davis26.1 Definition, 25126.2 Immunologic mechanisms, 251References, 25427 Plasmapheresis, 257Nathan M. Slovis27.1 Definition, 25727.2 Methods for preparing plasma products, 25727.3 Apheresis, 25827.4 Therapeutic plasmapheresis, 25827.5 Complications of therapeutic plasmapheresis, 260References, 26028 Principles of Vaccination, 263Noah D. Cohen and Angela I. Bordin28.1 Definition, 26328.2 Efficacy and effectiveness of vaccines, 26328.3 Safety of vaccines, 27128.4 Key knowledge-gaps in equine vaccinology, 27328.5 Protocols for vaccination, 275References, 27629 Types of Vaccines, 279Angela I. Bordin and Noah D. Cohen29.1 Definition, 27929.2 Immunologic mechanisms, 27929.3 Immune responses to vaccination, 28229.4 Routes of vaccination, 28429.5 Adjuvants and vaccine delivery systems, 28529.6 Important diseases with unavailable effective vaccines, 285References, 28630 Transplantation Immunology, 289Rebecca L. Tallmadge30.1 Definition, 28930.2 Equine MHC genes: genomic organization and variation, 28930.3 Determining equine MHC haplotypes, 29030.4 Immunosuppression and engraftment, 29130.5 Graft rejection, 29230.6 Current transplantation applications, 293References, 29431 Mesenchymal Stem Cell Therapy, 297Gerlinde R. Van de Walle, Catharina De Schauwer and Lisa A. Fortier31.1 Definition, 29731.2 Regenerative functions of mesenchymal stem cells, 29731.3 Immunologic mechanisms and associations, 29831.4 Sources of equine mesenchymal stem cells, 29931.5 Characterization of equine mesenchymal stem cells, 30031.6 Applications of equine mesenchymal stem cells in equine regenerative medicine, 302References, 30632 Hematopoietic Stem Cell Transplantation, 311M. Julia B. Felippe32.1 Definition, 31132.2 Hematopoietic stem cell sources, 31132.3 Pre-transplantation conditioning, 31332.4 Post-transplantation immunosuppression, 31332.5 Hematopoietic stem cell transplantation in the horse, 313References, 315Index, 317