Bladder Cancer

Seth P. Lerner, Professor of Urology and Beth and Dave Swalm Chair in Urologic Oncology, Baylor College of Medicine, Houston, TX, USA Mark P. Schoenberg, MD, Professor and University Chair, The Department of Urology, The Montefiore Medical Center & The Albert Einstein College of Medicine, Bronx, NY USACora N. Sternberg, Chief, Department of Medical Oncology, San Camillo Forlanini Hospital, Rome, Italy and Adjunct Professor at La Sapienza University in Rome.

• List of contributors viiPreface xiiAcknowledgments xiiiPart I: Diagnosis and treatment of non-muscle-invasive bladder cancer1 Pathology 3Hikmat Al-Ahmadie and Donna E. Hansel2 Risk stratification of high]grade Ta CIS and T1 urothelial carcinoma of the bladder 18Tobias Klatte, Fred Witjes, Gary Steinberg, and Shahrokh F. Shariat3 Utility of urine biomarkers 26Derya Tilki and Alexandre R. Zlotta4 Novel endoscopic techniques for the detection of bladder cancer 39Ayman Soubra, Joseph C. Liao, and Badrinath Konety5 Transurethral resection of bladder tumors 51Jen-Jane Liu and Mark P. Schoenberg6 Intravesical chemotherapy 64Levent N. Türkeri, M.Guillaume Wientjes, and Jessie L.S. Au7 Intravesical immunotherapy 76Nilay M. Gandhi, Laura A. Bertrand, Donald L. Lamm, and Michael A. O’Donnell8 HGT1 bladder cancer: Diagnosis and treatment 89J.M. Gaya, J. Palou, and Edward M. Messing9 What to do when bacillus Calmette-Guérin fails 98Massimiliano Spaliviero, Guido Dalbagni, and Matthew NielsenPart II: T2–410 Selection and perioperative management of patients undergoing radical cystectomy and urinary reconstruction 111Robert S. Svatek and Alon Z. Weizer11 Radical cystectomy: Techniques and outcomes 127Siamak Daneshmand and Seth P. Lerner12 Cystectomy in the female patient 144Ryan Werntz, Georgios Gakis, Theresa Koppie, and Arnulf Stenzl13 Laparoscopic/robotic radical cystectomy and urinary diversion: Outcomes 156Kristina Wittig, Kevin Chan, Mark Kawachi, and Timothy G. Wilson14 Robotic assisted radical cystectomy and urinary diversion: Clinical trials 167George J.S. Kallingal, Angela B. Smith, Raj S. Pruthi, and Dipen J. Parekh15 Role of extended lymphadenectomy 176Eugene K. Cha, George N. Thalmann, and Bernard H. Bochner16 Management of the urethra in the cystectomy patient 184Kamal S. Pohar and Norm D. Smith17 The role of radical cystectomy in patients with unresectable or regionally metastatic urothelial carcinoma of the bladder 190Scott Delacroix Jr, Nathan Lawrentschuk, and Ashish M. KamatPart III: Primary bladder-sparing therapy18 Radical transurethral resection 201Eduardo Solsona and Harry W. Herr19 Partial cystectomy 212Ahmed Haddad, Yair Lotan, and Arthur I. Sagalowsky20 Integrating chemotherapy and radiotherapy for bladder cancer 221Lior Z. Braunstein, William U. Shipley, Nicholas D. James, Andrea B. Apolo, and Jason A. EfstathiouPart IV: Urinary tract reconstruction21 Orthotopic neobladder 235Eila C. Skinner22 Continent cutaneous diversion 244Andreas Neisius and Joachim W. Thüroff23 Non]continent urinary diversion 258Michael Rink, Fredrik Liedberg, and Margit FischPart V: Treatment of regionally advanced and metastatic bladder cancer24 Molecular determinants of chemotherapy response 273Matthew I. Milowsky, Peter H. O’Donnell, Thomas W. Flaig, and Dan Theodorescu25 Neoadjuvant chemotherapy in the treatment of muscle-invasive bladder cancer 284David I. Quinn and Cora N. Sternberg26 Adjuvant chemotherapy for invasive bladder cancer 295André P. Fay, Jeffrey J. Leow, and Joaquim Bellmunt27 Treatment of metastatic bladder cancer 304Gopa Iyer, Fabio Calabró, and Dean F. Bajorin28 Treatment of poor risk patients 320Maria De Santis and Matthew D. GalskyPart VI: Genomics and the current status of urothelial cancer29 Molecular events in muscle]invasive bladder cancer development 329Jonathan Rosenberg, William Y. Kim, Jaegil Kim, and David J. Kwiatkowski30 Cancer stem cells and intrinsic subtypes in bladder cancer 342Keith Syson Chan and David J. McConkey31 Multi-targeted agents in the treatment of urothelial carcinoma 353Noah M. Hahn, Colin P.N. Dinney, and Guru SonpavdePart VII: Optimizing healthcare delivery32 Patient navigation and cancer navigator programs 365Scott M. Gilbert and Michael Porter33 Impact of health services on compliance and outcomes 375Heather Honoré Goltz, Marc A. Kowalkowski, G. John Chen, and David M. Latini34 Quality of life and survivorship 384Nihal E. Mohamed and Cheryl T. Lee35 Bladder cancer: Healthcare delivery and third party payers 395Seth A. Strope and John L. Gore36 Bladder cancer patient advocacy: Creating partnerships to advance patient care research and clinical trials 402Diane Zipursky Quale and Rick BangsIndex 409