Anil K. Nair, MD, Director, Alzheimers Disease Center, Quincy Medical Center, Quincy, MA, USA.Marwan N. Sabbagh, MD, Director, Banner Sun Health Research Institute and Research Professor ofNeurology, University of Arizona College of Medicine, Phoenix AZ, USA.

• About the Editors, viiList of Contributors, viiiPreface, xiiAcknowledgments, xiiiPart 1 The Aging Brain in Neurology, 11 The Biology of Aging: Implications for Diseases of Aging and Health Care in the Twenty-First Century, 3Douglas F. Watt2 Functional Changes Associated with the Aging Nervous System, 38Julie A. Schneider and Chunhui YangPart 2 Assessment of the Geriatric Neurology Patient, 693 Approach to the Geriatric Neurology Patient: The Neurologic Examination, 71Marwan N. Sabbagh and Anil K. Nair4 Assessment of Cognitive Status in Geriatric Neurology, 854.1 Mental Status Examination in the Geriatric Neurology Patient, 87Papan Thaipisuttikul and James E. Galvin4.2 Neuropsychology in Geriatric Neurology, 98Donald J. Connor and Marc A. Norman5 Cognitive Reserve and the Aging Brain, 118Adrienne M. Tucker and Yaakov Stern6 Gait Disorders in the Graying Population, 126Joe Verghese and Jessica Zwerling7 Imaging of the Geriatric Brain, 1367.1 Structural Neuroimaging in Degenerative Dementias, 138Liana G. Apostolova7.2 Functional Imaging in Dementia, 146Adam S. Fleisher and Alexander Drzezga7.3 Amyloid Imaging, 162Anil K. Nair and Marwan N. Sabbagh8 Clinical Laboratory Investigations in Geriatric Neurology, 170Geoffrey S. Baird and Thomas J. MontinePart 3 Neurologic Conditions in the Elderly, 1819 Cognitive Impairment and the Dementias, 1839.1 Mild Cognitive Impairment, 187Ranjan Duara, Miriam Jocelyn Rodriguez, and David A. Loewenstein9.2 Alzheimer’s Disease, 200Martin R. Farlow9.3 Dementia with Lewy Bodies, 208Clive Ballard9.4 Vascular Cognitive Impairment, 224Helena C. Chui and Freddi Segal-Gidan9.5 Frontotemporal Dementia, 239David Perry and Howard Rosen9.6 Primary Progressive Aphasia, 251Maya L. Henry, Stephen M. Wilson, and Steven Z. Rapcsak9.7 Prion Diseases, 267Michael D. Geschwind and Katherine Wong9.8 Normal Pressure Hydrocephalus, 281Norman R. Relkin10 Depression in the Elderly: Interactions with Aging, Stress, Chronic Pain, Infl ammation, and Neurodegenerative Disorders, 287Douglas F. Watt11 Cerebrovascular Diseases in Geriatrics, 302Patrick Lyden, Khalil Amir and Ilana Tidus12 Movement Disorders, 31312.1 Parkinson’s Disease, 315Robert Fekete and Joseph Jankovic12.2 Essential Tremor and Other Tremor Disorders, 325Holly Shill12.3 Progressive Supranuclear Palsy, 333Virgilio Gerald H. Evidente12.4 Corticobasal Degeneration, 344Katrina Gwinn13 Sleep Disorders, 347Sanford Auerbach14 Autonomic Dysfunction and Syncope, 358Rohit R. Das15 Geriatric Epilepsy, 370David V. Lardizabal16 Vertigo and Dizziness in the Elderly, 379Terry D. Fife and Salih Demirhan17 Disorders of the Special Senses in the Elderly, 396Douglas J. Lanska18 Nervous System Infections, 460Ronald Ellis, David Croteau, and Suzi Hong19 Delirium, 478Alan Lerner, Stefani Parrisbalogun, and Joseph Locala20 Headache in the Elderly, 486Brian McGeeney21 Neuromuscular Disorders, 494Heber Varela and Clifton GoochPart 4 Therapeutics for the Geriatric Neurology Patient, 51922 Neurosurgical Care of the Geriatric Patient, 521David Fusco, Rasha Germain, and Peter Nakaji23 Treatment of Dementia, 55623.1 Evidence-Based Pharmacologic Treatment of Dementia, 557Jasmeet Singh, Marwan N. Sabbagh, and Anil K. Nair23.2 Immunotherapy for Alzheimer’s Disease, 574Michael Grundman, Gene G. Kinney, Eric Yuen, and Ronald Black24 Geriatric Psychopharmacology, 586Sandra A. Jacobson25 Nonpharmacologic Treatment of Behavioral Problems in Persons with Dementia, 615Gary A. Martin and John Ranseen26 Expressive Art Therapies in Geriatric Neurology, 630Daniel C. Potts, Bruce L. Miller, Carol A. Prickett,Andrea M. Cevasco, and Angel C. DuncanPart 5 Important Management Issues Beyond Therapeutics in the Geriatric Neurology Patient, 64527 Dietary Factors in Geriatric Neurology, 647Yian Gu and Nikolaos Scarmeas28 Exercising the Brain: Nonpharmacologic Interventions for Cognitive Decline Associated with Aging and Dementia, 669Brenna A. Cholerton, Jeannine Skinner, and Laura D. Baker29 Driving Impairment in Older Adults, 682Anne D. Halli-Tierney and Brian R. Ott30 Elder Abuse and Mistreatment, 699Elliott Schulman, Ashley Roque, and Anna Hohler31 Advocacy in Geriatric Neurology, 707Glenn Finney and Anil K. NairIndex, 713

Anil K. Nair, MD, Director, Alzheimers Disease Center, Quincy Medical Center, Quincy, MA, USA.Marwan N. Sabbagh, MD, Director, Banner Sun Health Research Institute and Research Professor ofNeurology, University of Arizona College of Medicine, Phoenix AZ, USA.

• About the Editors, viiList of Contributors, viiiPreface, xiiAcknowledgments, xiiiPart 1 The Aging Brain in Neurology, 11 The Biology of Aging: Implications for Diseases of Aging and Health Care in the Twenty-First Century, 3Douglas F. Watt2 Functional Changes Associated with the Aging Nervous System, 38Julie A. Schneider and Chunhui YangPart 2 Assessment of the Geriatric Neurology Patient, 693 Approach to the Geriatric Neurology Patient: The Neurologic Examination, 71Marwan N. Sabbagh and Anil K. Nair4 Assessment of Cognitive Status in Geriatric Neurology, 854.1 Mental Status Examination in the Geriatric Neurology Patient, 87Papan Thaipisuttikul and James E. Galvin4.2 Neuropsychology in Geriatric Neurology, 98Donald J. Connor and Marc A. Norman5 Cognitive Reserve and the Aging Brain, 118Adrienne M. Tucker and Yaakov Stern6 Gait Disorders in the Graying Population, 126Joe Verghese and Jessica Zwerling7 Imaging of the Geriatric Brain, 1367.1 Structural Neuroimaging in Degenerative Dementias, 138Liana G. Apostolova7.2 Functional Imaging in Dementia, 146Adam S. Fleisher and Alexander Drzezga7.3 Amyloid Imaging, 162Anil K. Nair and Marwan N. Sabbagh8 Clinical Laboratory Investigations in Geriatric Neurology, 170Geoffrey S. Baird and Thomas J. MontinePart 3 Neurologic Conditions in the Elderly, 1819 Cognitive Impairment and the Dementias, 1839.1 Mild Cognitive Impairment, 187Ranjan Duara, Miriam Jocelyn Rodriguez, and David A. Loewenstein9.2 Alzheimer’s Disease, 200Martin R. Farlow9.3 Dementia with Lewy Bodies, 208Clive Ballard9.4 Vascular Cognitive Impairment, 224Helena C. Chui and Freddi Segal-Gidan9.5 Frontotemporal Dementia, 239David Perry and Howard Rosen9.6 Primary Progressive Aphasia, 251Maya L. Henry, Stephen M. Wilson, and Steven Z. Rapcsak9.7 Prion Diseases, 267Michael D. Geschwind and Katherine Wong9.8 Normal Pressure Hydrocephalus, 281Norman R. Relkin10 Depression in the Elderly: Interactions with Aging, Stress, Chronic Pain, Infl ammation, and Neurodegenerative Disorders, 287Douglas F. Watt11 Cerebrovascular Diseases in Geriatrics, 302Patrick Lyden, Khalil Amir and Ilana Tidus12 Movement Disorders, 31312.1 Parkinson’s Disease, 315Robert Fekete and Joseph Jankovic12.2 Essential Tremor and Other Tremor Disorders, 325Holly Shill12.3 Progressive Supranuclear Palsy, 333Virgilio Gerald H. Evidente12.4 Corticobasal Degeneration, 344Katrina Gwinn13 Sleep Disorders, 347Sanford Auerbach14 Autonomic Dysfunction and Syncope, 358Rohit R. Das15 Geriatric Epilepsy, 370David V. Lardizabal16 Vertigo and Dizziness in the Elderly, 379Terry D. Fife and Salih Demirhan17 Disorders of the Special Senses in the Elderly, 396Douglas J. Lanska18 Nervous System Infections, 460Ronald Ellis, David Croteau, and Suzi Hong19 Delirium, 478Alan Lerner, Stefani Parrisbalogun, and Joseph Locala20 Headache in the Elderly, 486Brian McGeeney21 Neuromuscular Disorders, 494Heber Varela and Clifton GoochPart 4 Therapeutics for the Geriatric Neurology Patient, 51922 Neurosurgical Care of the Geriatric Patient, 521David Fusco, Rasha Germain, and Peter Nakaji23 Treatment of Dementia, 55623.1 Evidence-Based Pharmacologic Treatment of Dementia, 557Jasmeet Singh, Marwan N. Sabbagh, and Anil K. Nair23.2 Immunotherapy for Alzheimer’s Disease, 574Michael Grundman, Gene G. Kinney, Eric Yuen, and Ronald Black24 Geriatric Psychopharmacology, 586Sandra A. Jacobson25 Nonpharmacologic Treatment of Behavioral Problems in Persons with Dementia, 615Gary A. Martin and John Ranseen26 Expressive Art Therapies in Geriatric Neurology, 630Daniel C. Potts, Bruce L. Miller, Carol A. Prickett,Andrea M. Cevasco, and Angel C. DuncanPart 5 Important Management Issues Beyond Therapeutics in the Geriatric Neurology Patient, 64527 Dietary Factors in Geriatric Neurology, 647Yian Gu and Nikolaos Scarmeas28 Exercising the Brain: Nonpharmacologic Interventions for Cognitive Decline Associated with Aging and Dementia, 669Brenna A. Cholerton, Jeannine Skinner, and Laura D. Baker29 Driving Impairment in Older Adults, 682Anne D. Halli-Tierney and Brian R. Ott30 Elder Abuse and Mistreatment, 699Elliott Schulman, Ashley Roque, and Anna Hohler31 Advocacy in Geriatric Neurology, 707Glenn Finney and Anil K. NairIndex, 713

Anil K. Nair, MD, Director, Alzheimers Disease Center, Quincy Medical Center, Quincy, MA, USA.Marwan N. Sabbagh, MD, Director, Banner Sun Health Research Institute and Research Professor ofNeurology, University of Arizona College of Medicine, Phoenix AZ, USA.

• About the Editors, viiList of Contributors, viiiPreface, xiiAcknowledgments, xiiiPart 1 The Aging Brain in Neurology, 11 The Biology of Aging: Implications for Diseases of Aging and Health Care in the Twenty-First Century, 3Douglas F. Watt2 Functional Changes Associated with the Aging Nervous System, 38Julie A. Schneider and Chunhui YangPart 2 Assessment of the Geriatric Neurology Patient, 693 Approach to the Geriatric Neurology Patient: The Neurologic Examination, 71Marwan N. Sabbagh and Anil K. Nair4 Assessment of Cognitive Status in Geriatric Neurology, 854.1 Mental Status Examination in the Geriatric Neurology Patient, 87Papan Thaipisuttikul and James E. Galvin4.2 Neuropsychology in Geriatric Neurology, 98Donald J. Connor and Marc A. Norman5 Cognitive Reserve and the Aging Brain, 118Adrienne M. Tucker and Yaakov Stern6 Gait Disorders in the Graying Population, 126Joe Verghese and Jessica Zwerling7 Imaging of the Geriatric Brain, 1367.1 Structural Neuroimaging in Degenerative Dementias, 138Liana G. Apostolova7.2 Functional Imaging in Dementia, 146Adam S. Fleisher and Alexander Drzezga7.3 Amyloid Imaging, 162Anil K. Nair and Marwan N. Sabbagh8 Clinical Laboratory Investigations in Geriatric Neurology, 170Geoffrey S. Baird and Thomas J. MontinePart 3 Neurologic Conditions in the Elderly, 1819 Cognitive Impairment and the Dementias, 1839.1 Mild Cognitive Impairment, 187Ranjan Duara, Miriam Jocelyn Rodriguez, and David A. Loewenstein9.2 Alzheimer’s Disease, 200Martin R. Farlow9.3 Dementia with Lewy Bodies, 208Clive Ballard9.4 Vascular Cognitive Impairment, 224Helena C. Chui and Freddi Segal-Gidan9.5 Frontotemporal Dementia, 239David Perry and Howard Rosen9.6 Primary Progressive Aphasia, 251Maya L. Henry, Stephen M. Wilson, and Steven Z. Rapcsak9.7 Prion Diseases, 267Michael D. Geschwind and Katherine Wong9.8 Normal Pressure Hydrocephalus, 281Norman R. Relkin10 Depression in the Elderly: Interactions with Aging, Stress, Chronic Pain, Infl ammation, and Neurodegenerative Disorders, 287Douglas F. Watt11 Cerebrovascular Diseases in Geriatrics, 302Patrick Lyden, Khalil Amir and Ilana Tidus12 Movement Disorders, 31312.1 Parkinson’s Disease, 315Robert Fekete and Joseph Jankovic12.2 Essential Tremor and Other Tremor Disorders, 325Holly Shill12.3 Progressive Supranuclear Palsy, 333Virgilio Gerald H. Evidente12.4 Corticobasal Degeneration, 344Katrina Gwinn13 Sleep Disorders, 347Sanford Auerbach14 Autonomic Dysfunction and Syncope, 358Rohit R. Das15 Geriatric Epilepsy, 370David V. Lardizabal16 Vertigo and Dizziness in the Elderly, 379Terry D. Fife and Salih Demirhan17 Disorders of the Special Senses in the Elderly, 396Douglas J. Lanska18 Nervous System Infections, 460Ronald Ellis, David Croteau, and Suzi Hong19 Delirium, 478Alan Lerner, Stefani Parrisbalogun, and Joseph Locala20 Headache in the Elderly, 486Brian McGeeney21 Neuromuscular Disorders, 494Heber Varela and Clifton GoochPart 4 Therapeutics for the Geriatric Neurology Patient, 51922 Neurosurgical Care of the Geriatric Patient, 521David Fusco, Rasha Germain, and Peter Nakaji23 Treatment of Dementia, 55623.1 Evidence-Based Pharmacologic Treatment of Dementia, 557Jasmeet Singh, Marwan N. Sabbagh, and Anil K. Nair23.2 Immunotherapy for Alzheimer’s Disease, 574Michael Grundman, Gene G. Kinney, Eric Yuen, and Ronald Black24 Geriatric Psychopharmacology, 586Sandra A. Jacobson25 Nonpharmacologic Treatment of Behavioral Problems in Persons with Dementia, 615Gary A. Martin and John Ranseen26 Expressive Art Therapies in Geriatric Neurology, 630Daniel C. Potts, Bruce L. Miller, Carol A. Prickett,Andrea M. Cevasco, and Angel C. DuncanPart 5 Important Management Issues Beyond Therapeutics in the Geriatric Neurology Patient, 64527 Dietary Factors in Geriatric Neurology, 647Yian Gu and Nikolaos Scarmeas28 Exercising the Brain: Nonpharmacologic Interventions for Cognitive Decline Associated with Aging and Dementia, 669Brenna A. Cholerton, Jeannine Skinner, and Laura D. Baker29 Driving Impairment in Older Adults, 682Anne D. Halli-Tierney and Brian R. Ott30 Elder Abuse and Mistreatment, 699Elliott Schulman, Ashley Roque, and Anna Hohler31 Advocacy in Geriatric Neurology, 707Glenn Finney and Anil K. NairIndex, 713