Matthew Rizzo is the Frances and Edgar Reynolds Professor and Chair of the Department of Neurological Sciences and Chief Physician for Neuroscience Clinical Programs at the University of Nebraska Medical Center.Steven Anderson is Associate Professor in the Department of Neurology and the Interdisciplinary Graduate Program of Neuroscience at the University of Iowa.Bernd Fritzsch is an Entrepreneurial Professor at the University of Iowa. He is also Director of the Center on Aging and Director of the Aging Mind and Brain Initiative.

This book constitutes a well-rounded review of the aging brain including basic neuroscience, normal aging, and how it relates to diseases of aging with ways to assess it. In addition, it tackles the ethical implications of aging now and in the future. The book does a good job of covering the different diseases of aging and groups them according to pathology and modes of treatment. Unique features include concise summaries of the associated basic science and good quality imaging. This is a valuable book for any person wishing to learn more about the aging brain and ways to prevent and treat diseases of the aging brain. It raises awareness of the policy issues that are currently overlooked and emphasizes the importance of understanding the aging brain better. - JANE KHALIFE, MD, Thomas Jefferson University

• List of Contributors viiiAcknowledgments xiiList of Abbreviations xivGlossary xxPart I Introduction 11 The Aging Mind and Brain: Overview 3Matthew Rizzo, Steven Anderson, and Bernd FritzschPart II Theoretical, Animal Models, Social, and Humanistic Perspectives 172 Social Networks, Social Relationships, and Their Effects on the Aging Mind and Brain 19Sato Ashida and Ellen J. Schafer3 Aging and the Brain 37Veena Prahlad and Madhusudana Rao Chikka4 Animal Models of Pathological Aging 61Eric B. Emmons, Youngcho Kim, and Nandakumar S. Narayanan5 Humanistic Perspectives: Arts and the Aging Mind 78Andrea Charise and Margaret L. EgintonPart III Methods of Assessment 1016 Medical Assessment of the Aging Mind and Brain 103T. Scott Diesing and Matthew Rizzo7 Neuropsychological Assessment of Aging Individuals 130R. D. Jones8 Normal Aging: Brain Morphologic, Chemical and Physiologic Changes Detected with in vivo MRI 146A. A. Capizzano, T. Moritani, M. Jacob, and David E. Warren9 Positron Emission Tomography (PET) Imaging: Principles and Potential Role in Understanding BrainFunction 164Laura L. Boles Ponto10 Electrophysiological Measures of Age-Related Cognitive Impairment In Humans 188David E. Anderson and Olga Taraschenko11 The Brain in the Wild: Tracking Human Behavior in Naturalistic Settings 204Gabriella E. M. Rizzo and Matthew Rizzo12 Quality of Life Assessment 223Fredric D. Wolinsky and Elena M. AndresenPart IV Brain Functions and Behavior Across the Lifespan 25313 Executive Functions and Behavior Across the Lifespan 255Paul J. Eslinger and Claire Flaherty14 Memory and Language in Aging: How Their Shared Cognitive Processes, Neural Correlates, andSupporting Mechanisms Change with Age 270David E. Warren, Rachael Rubin, Samantha Shune, and Melissa C. Duff15 Vision and Aging 296Cynthia Owsley, Deepta Ghate, and Sachin Kedar16 Aging-Related Balance Impairment and Hearing Loss 315Deema Fattal, Marlan Hansen, and Bernd Fritzsch17 Attention and Processing Speed 337Benjamin D. Lester, Daniel B. Vatterott, and Shaun P. Vecera18 Motor Functions and Mobility 362Warren G. Darling, Kelly J. Cole, and James A. Ashton-Miller19 Incontinence and Sexual Dysfunction 389Karl J. Kreder, Sarah Fraumann Faris, Matthew Rizzo, and Satish S-C. Rao20 Emotional Function During Aging 417Kuan-Hua Chen and Steven W. AndersonPart V Brain Disease and Dysfunction 44521 Alzheimer’s Disease and Mild Cognitive Impairment 447David T. Jones, Marla B. Bruns, and Ronald C. Petersen22 Cerebrovascular Disease and White Matter Disorders 483Nandakumar Nagaraja and Enrique C. Leira23 Movement Disorders 523Dronacharya Lamichhane and Ergun Y. Uc24 Psychiatric Disorders 541Steven P. Wengel, Roberto F. Cervantes, and William J. Burke25 Encephalopathy 553Alberto Serrano-Pozo26 Traumatic Brain Injury and Neurodegenerative Disease 591Dawn McGuire27 Sleep and Sleep Disorders in Older Adults 619Jon Tippin28 Pain 628Keela Herr, Stephen Gibson, and Thomas HadjistavropoulosPart VI Optimizing Brain Function in Health and Disease 64929 The Benefits of Physical Activity on Brain Structure and Function in Healthy Aging and Age-RelatedNeurological Disease 651Michelle W. Voss30 Aging, Mind and Brain: A Human Factors Engineering Perspective 662Sara J. Czaja31 Community and Long-Term Care Supports for Older Adults with Cognitive Decline 673Kristine Williams and Ying-Ling JaoPart VII Legal and Ethical Issues 68732 Neuroethics of Aging 689Steven Anderson33 The Public Health Challenge Presented by the Growing Population of Persons with Alzheimer’s Disease and Other Forms of Dementia: A Survey of American Public Policy Activity 702Brian P. Kaskie and Christopher Stamy34 Competency and Capacity in the Aging Adult 723Joseph Barrash35 Boomers After the Bust: Ageism and Employment Discrimination Trends After the Great Recession 742Helen D. (Heidi) Reavis and Alison Roh ParkPart VIII Conclusion 76136 Science, Society, and a Vision for Mind and Brain Health Across the Lifespan 763Matthew Rizzo, Steven Anderson, and Bernd FritzschIndex 769

Matthew Rizzo is the Frances and Edgar Reynolds Professor and Chair of the Department of Neurological Sciences and Chief Physician for Neuroscience Clinical Programs at the University of Nebraska Medical Center.Steven Anderson is Associate Professor in the Department of Neurology and the Interdisciplinary Graduate Program of Neuroscience at the University of Iowa.Bernd Fritzsch is an Entrepreneurial Professor at the University of Iowa. He is also Director of the Center on Aging and Director of the Aging Mind and Brain Initiative.

This book constitutes a well-rounded review of the aging brain including basic neuroscience, normal aging, and how it relates to diseases of aging with ways to assess it. In addition, it tackles the ethical implications of aging now and in the future. The book does a good job of covering the different diseases of aging and groups them according to pathology and modes of treatment. Unique features include concise summaries of the associated basic science and good quality imaging. This is a valuable book for any person wishing to learn more about the aging brain and ways to prevent and treat diseases of the aging brain. It raises awareness of the policy issues that are currently overlooked and emphasizes the importance of understanding the aging brain better. - JANE KHALIFE, MD, Thomas Jefferson University

• List of Contributors viiiAcknowledgments xiiList of Abbreviations xivGlossary xxPart I Introduction 11 The Aging Mind and Brain: Overview 3Matthew Rizzo, Steven Anderson, and Bernd FritzschPart II Theoretical, Animal Models, Social, and Humanistic Perspectives 172 Social Networks, Social Relationships, and Their Effects on the Aging Mind and Brain 19Sato Ashida and Ellen J. Schafer3 Aging and the Brain 37Veena Prahlad and Madhusudana Rao Chikka4 Animal Models of Pathological Aging 61Eric B. Emmons, Youngcho Kim, and Nandakumar S. Narayanan5 Humanistic Perspectives: Arts and the Aging Mind 78Andrea Charise and Margaret L. EgintonPart III Methods of Assessment 1016 Medical Assessment of the Aging Mind and Brain 103T. Scott Diesing and Matthew Rizzo7 Neuropsychological Assessment of Aging Individuals 130R. D. Jones8 Normal Aging: Brain Morphologic, Chemical and Physiologic Changes Detected with in vivo MRI 146A. A. Capizzano, T. Moritani, M. Jacob, and David E. Warren9 Positron Emission Tomography (PET) Imaging: Principles and Potential Role in Understanding BrainFunction 164Laura L. Boles Ponto10 Electrophysiological Measures of Age-Related Cognitive Impairment In Humans 188David E. Anderson and Olga Taraschenko11 The Brain in the Wild: Tracking Human Behavior in Naturalistic Settings 204Gabriella E. M. Rizzo and Matthew Rizzo12 Quality of Life Assessment 223Fredric D. Wolinsky and Elena M. AndresenPart IV Brain Functions and Behavior Across the Lifespan 25313 Executive Functions and Behavior Across the Lifespan 255Paul J. Eslinger and Claire Flaherty14 Memory and Language in Aging: How Their Shared Cognitive Processes, Neural Correlates, andSupporting Mechanisms Change with Age 270David E. Warren, Rachael Rubin, Samantha Shune, and Melissa C. Duff15 Vision and Aging 296Cynthia Owsley, Deepta Ghate, and Sachin Kedar16 Aging-Related Balance Impairment and Hearing Loss 315Deema Fattal, Marlan Hansen, and Bernd Fritzsch17 Attention and Processing Speed 337Benjamin D. Lester, Daniel B. Vatterott, and Shaun P. Vecera18 Motor Functions and Mobility 362Warren G. Darling, Kelly J. Cole, and James A. Ashton-Miller19 Incontinence and Sexual Dysfunction 389Karl J. Kreder, Sarah Fraumann Faris, Matthew Rizzo, and Satish S-C. Rao20 Emotional Function During Aging 417Kuan-Hua Chen and Steven W. AndersonPart V Brain Disease and Dysfunction 44521 Alzheimer’s Disease and Mild Cognitive Impairment 447David T. Jones, Marla B. Bruns, and Ronald C. Petersen22 Cerebrovascular Disease and White Matter Disorders 483Nandakumar Nagaraja and Enrique C. Leira23 Movement Disorders 523Dronacharya Lamichhane and Ergun Y. Uc24 Psychiatric Disorders 541Steven P. Wengel, Roberto F. Cervantes, and William J. Burke25 Encephalopathy 553Alberto Serrano-Pozo26 Traumatic Brain Injury and Neurodegenerative Disease 591Dawn McGuire27 Sleep and Sleep Disorders in Older Adults 619Jon Tippin28 Pain 628Keela Herr, Stephen Gibson, and Thomas HadjistavropoulosPart VI Optimizing Brain Function in Health and Disease 64929 The Benefits of Physical Activity on Brain Structure and Function in Healthy Aging and Age-RelatedNeurological Disease 651Michelle W. Voss30 Aging, Mind and Brain: A Human Factors Engineering Perspective 662Sara J. Czaja31 Community and Long-Term Care Supports for Older Adults with Cognitive Decline 673Kristine Williams and Ying-Ling JaoPart VII Legal and Ethical Issues 68732 Neuroethics of Aging 689Steven Anderson33 The Public Health Challenge Presented by the Growing Population of Persons with Alzheimer’s Disease and Other Forms of Dementia: A Survey of American Public Policy Activity 702Brian P. Kaskie and Christopher Stamy34 Competency and Capacity in the Aging Adult 723Joseph Barrash35 Boomers After the Bust: Ageism and Employment Discrimination Trends After the Great Recession 742Helen D. (Heidi) Reavis and Alison Roh ParkPart VIII Conclusion 76136 Science, Society, and a Vision for Mind and Brain Health Across the Lifespan 763Matthew Rizzo, Steven Anderson, and Bernd FritzschIndex 769

Matthew Rizzo is the Frances and Edgar Reynolds Professor and Chair of the Department of Neurological Sciences and Chief Physician for Neuroscience Clinical Programs at the University of Nebraska Medical Center.Steven Anderson is Associate Professor in the Department of Neurology and the Interdisciplinary Graduate Program of Neuroscience at the University of Iowa.Bernd Fritzsch is an Entrepreneurial Professor at the University of Iowa. He is also Director of the Center on Aging and Director of the Aging Mind and Brain Initiative.

This book constitutes a well-rounded review of the aging brain including basic neuroscience, normal aging, and how it relates to diseases of aging with ways to assess it. In addition, it tackles the ethical implications of aging now and in the future. The book does a good job of covering the different diseases of aging and groups them according to pathology and modes of treatment. Unique features include concise summaries of the associated basic science and good quality imaging. This is a valuable book for any person wishing to learn more about the aging brain and ways to prevent and treat diseases of the aging brain. It raises awareness of the policy issues that are currently overlooked and emphasizes the importance of understanding the aging brain better. - JANE KHALIFE, MD, Thomas Jefferson University

• List of Contributors viiiAcknowledgments xiiList of Abbreviations xivGlossary xxPart I Introduction 11 The Aging Mind and Brain: Overview 3Matthew Rizzo, Steven Anderson, and Bernd FritzschPart II Theoretical, Animal Models, Social, and Humanistic Perspectives 172 Social Networks, Social Relationships, and Their Effects on the Aging Mind and Brain 19Sato Ashida and Ellen J. Schafer3 Aging and the Brain 37Veena Prahlad and Madhusudana Rao Chikka4 Animal Models of Pathological Aging 61Eric B. Emmons, Youngcho Kim, and Nandakumar S. Narayanan5 Humanistic Perspectives: Arts and the Aging Mind 78Andrea Charise and Margaret L. EgintonPart III Methods of Assessment 1016 Medical Assessment of the Aging Mind and Brain 103T. Scott Diesing and Matthew Rizzo7 Neuropsychological Assessment of Aging Individuals 130R. D. Jones8 Normal Aging: Brain Morphologic, Chemical and Physiologic Changes Detected with in vivo MRI 146A. A. Capizzano, T. Moritani, M. Jacob, and David E. Warren9 Positron Emission Tomography (PET) Imaging: Principles and Potential Role in Understanding BrainFunction 164Laura L. Boles Ponto10 Electrophysiological Measures of Age-Related Cognitive Impairment In Humans 188David E. Anderson and Olga Taraschenko11 The Brain in the Wild: Tracking Human Behavior in Naturalistic Settings 204Gabriella E. M. Rizzo and Matthew Rizzo12 Quality of Life Assessment 223Fredric D. Wolinsky and Elena M. AndresenPart IV Brain Functions and Behavior Across the Lifespan 25313 Executive Functions and Behavior Across the Lifespan 255Paul J. Eslinger and Claire Flaherty14 Memory and Language in Aging: How Their Shared Cognitive Processes, Neural Correlates, andSupporting Mechanisms Change with Age 270David E. Warren, Rachael Rubin, Samantha Shune, and Melissa C. Duff15 Vision and Aging 296Cynthia Owsley, Deepta Ghate, and Sachin Kedar16 Aging-Related Balance Impairment and Hearing Loss 315Deema Fattal, Marlan Hansen, and Bernd Fritzsch17 Attention and Processing Speed 337Benjamin D. Lester, Daniel B. Vatterott, and Shaun P. Vecera18 Motor Functions and Mobility 362Warren G. Darling, Kelly J. Cole, and James A. Ashton-Miller19 Incontinence and Sexual Dysfunction 389Karl J. Kreder, Sarah Fraumann Faris, Matthew Rizzo, and Satish S-C. Rao20 Emotional Function During Aging 417Kuan-Hua Chen and Steven W. AndersonPart V Brain Disease and Dysfunction 44521 Alzheimer’s Disease and Mild Cognitive Impairment 447David T. Jones, Marla B. Bruns, and Ronald C. Petersen22 Cerebrovascular Disease and White Matter Disorders 483Nandakumar Nagaraja and Enrique C. Leira23 Movement Disorders 523Dronacharya Lamichhane and Ergun Y. Uc24 Psychiatric Disorders 541Steven P. Wengel, Roberto F. Cervantes, and William J. Burke25 Encephalopathy 553Alberto Serrano-Pozo26 Traumatic Brain Injury and Neurodegenerative Disease 591Dawn McGuire27 Sleep and Sleep Disorders in Older Adults 619Jon Tippin28 Pain 628Keela Herr, Stephen Gibson, and Thomas HadjistavropoulosPart VI Optimizing Brain Function in Health and Disease 64929 The Benefits of Physical Activity on Brain Structure and Function in Healthy Aging and Age-RelatedNeurological Disease 651Michelle W. Voss30 Aging, Mind and Brain: A Human Factors Engineering Perspective 662Sara J. Czaja31 Community and Long-Term Care Supports for Older Adults with Cognitive Decline 673Kristine Williams and Ying-Ling JaoPart VII Legal and Ethical Issues 68732 Neuroethics of Aging 689Steven Anderson33 The Public Health Challenge Presented by the Growing Population of Persons with Alzheimer’s Disease and Other Forms of Dementia: A Survey of American Public Policy Activity 702Brian P. Kaskie and Christopher Stamy34 Competency and Capacity in the Aging Adult 723Joseph Barrash35 Boomers After the Bust: Ageism and Employment Discrimination Trends After the Great Recession 742Helen D. (Heidi) Reavis and Alison Roh ParkPart VIII Conclusion 76136 Science, Society, and a Vision for Mind and Brain Health Across the Lifespan 763Matthew Rizzo, Steven Anderson, and Bernd FritzschIndex 769