EDITED BY William K. Oh, MD Chief, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York Ajai Chari, MD Associate Professor of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York SERIES EDITOR Scott L. Friedman, MD Fishberg Professor of Medicine; Dean for Therapeutic Discovery; Chief, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA

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• Contributors ixSeries Foreword xviiPreface xviiiList of Abbreviations xixAbout the Companion Website xxviiiPart 1: Oncology1 Breast Cancer 3Jeanette Guziel and Charles L. Shapiro2 Prostate Cancer 23Reza Mehrazin and William K. Oh3 Bladder Cancer 32Matthew D. Galsky4 Renal Cancer 43Bobby C. Liaw, Reza Mehrazin, and Che-Kai Tsao5 Testicular Cancer 56Aditya V. Shreenivas and Seth M. Cohen6 Lung Cancer 66Rajwanth Veluswamy and Jorge E. Gomez7 Malignant Mesothelioma 79Nicholas C. Rohs and Zishuo I. Hu8 Liver Cancer 89Augusto Villanueva, Myron E. Schwartz, and Josep M. Llovet9 Gallbladder/Biliary Duct Cancers 101Rajwanth Veluswamy, Anuja Kriplani, and Celina Ang10 Pancreas Cancer 111Max W. Sung11 Colorectal Cancer 118Kenneth L. Angelino, Jason W. Steinberg, and Peter S. Kozuch12 Gastric Cancer 131Sofya Pintova13 Esophageal Cancer 139Madhuri Rao and Andrea S. Wolf14 Anal Cancer 153Ashley J. D’Silva, Danielle S. Seiden, and Peter S. Kozuch15 Invasive Epithelial Ovarian Cancer 166Brittney S. Zimmerman, Jeanette Guziel, and Amy Tiersten16 Endometrial Cancer 181Jamal Rahaman and Carmel J. Cohen17 Cervical Cancer 194Navya Nair, Ann Marie Beddoe, and Peter Dottino18 Melanoma 204Philip Friedlander and Corazon B. Cajulis19 Sarcomas 214Robert G. Maki20 Thyroid Cancer 221Aaron M. Etra and Krzysztof Misiukiewicz21 Head and Neck Cancer 230Le Min Lee and Bruce E. Culliney22 Brain Tumors 241Rebecca M. Brown and Ad´ılia Hormigo23 Neuroendocrine Tumors 255Richard R.P. Warner, Jacob A. Martin, and Michelle K. KimPart 2: Malignant Hematology24 Myeloproliferative Neoplasms 271Sangeetha Venugopal, Daniel Aruch, and John Mascarenhas25 Myelodysplastic Syndromes 288Thomas U. Marron and Lewis R. Silverman26 Multiple Myeloma and Plasma Cell Disorders 298Siyang Leng and Ajai Chari27 Acute Myeloid Leukemia 308Kevin Barley and Shyamala C. Navada28 Acute Lymphoblastic Leukemia 319Jaclyn C. Davis and Birte Wistinghausen29 Chronic Lymphocytic Leukemia 332Adam F. Binder and Janice L. Gabrilove30 Non-Hodgkin Lymphoma 342Adam F. Binder and Joshua D. Brody31 Hodgkin Lymphoma 354Jonah Shulman, Parth R. Rao, and Akshay Sudhindra32 Primary Central Nervous System Lymphoma 364Rebecca M. Brown and Ad´ılia HormigoPart 3: BONE MARROW TRANSPLANT33 Autologous Stem Cell Transplantation for Plasma Cell Disorders 379Keren Osman34 Allogeneic Stem Cell Transplantation Overview 385Parth R. Rao, Amir Steinberg, and Luis Isola35 Allogeneic Stem Cell Transplantation for AML and MDS 392Alla Keyzner36 Stem Cell Transplantation for Lymphoproliferative Disorders 400Doyun Park, Eileen Scigliano, and Amir Steinberg37 Infectious Complications of Stem Cell Transplantation 404Meenakshi M. Rana and Amir Steinberg38 Acute Graft Versus Host Disease 412Anne S. Renteria, James L.M. Ferrara, and John E. LevinePart 4: Multidisciplinary Care of Cancer Patients39 Oncologic Emergencies 423Scot A. Niglio and Adriana K. Malone40 Thrombosis in Cancer Patients 435Doyun Park, Caroline Cromwell, Mala Varma, and Ilan Shapira41 Imaging of Cancer Patients 447Idoia Corcuera-Solano, Mathilde Wagner, and Bachir Taouli42 Overview of Radiation Oncology 454Ronald D. Ennis43 Orthopedic Oncology 463Meredith K. Bartelstein and Ilya Iofin44 Ophthalmologic Oncology 473Albert Y. Wu and Kalla A. Gervasio45 Cardio-Oncology 486Gagan Sahni46 Psychiatric and Psychologic Dimensions of Cancer Care 501Talia Wiesel47 Geriatric Oncology 514Ali John Zarrabi, Ran Huo, and Cardinale B. Smith48 Palliative Care 519Lori Spoozak and Bethann Scarborough49 Nutrition and Symptom Management 528Paula Occiano, Melissa Nagelberg, and Raquela Adelsberg50 Cancer Survivorship 535Lindsay Haines and Charles L. Shapiro51 Pediatric Cancer: Solid Tumors and Lymphoma 543Surabhi Batra and Birte Wistinghausen52 Pediatric Cancer: Brain Tumors 556Surabhi Batra and Birte WistinghausenIndex 566

EDITED BY William K. Oh, MD Chief, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York Ajai Chari, MD Associate Professor of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York SERIES EDITOR Scott L. Friedman, MD Fishberg Professor of Medicine; Dean for Therapeutic Discovery; Chief, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA

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• Contributors ixSeries Foreword xviiPreface xviiiList of Abbreviations xixAbout the Companion Website xxviiiPart 1: Oncology1 Breast Cancer 3Jeanette Guziel and Charles L. Shapiro2 Prostate Cancer 23Reza Mehrazin and William K. Oh3 Bladder Cancer 32Matthew D. Galsky4 Renal Cancer 43Bobby C. Liaw, Reza Mehrazin, and Che-Kai Tsao5 Testicular Cancer 56Aditya V. Shreenivas and Seth M. Cohen6 Lung Cancer 66Rajwanth Veluswamy and Jorge E. Gomez7 Malignant Mesothelioma 79Nicholas C. Rohs and Zishuo I. Hu8 Liver Cancer 89Augusto Villanueva, Myron E. Schwartz, and Josep M. Llovet9 Gallbladder/Biliary Duct Cancers 101Rajwanth Veluswamy, Anuja Kriplani, and Celina Ang10 Pancreas Cancer 111Max W. Sung11 Colorectal Cancer 118Kenneth L. Angelino, Jason W. Steinberg, and Peter S. Kozuch12 Gastric Cancer 131Sofya Pintova13 Esophageal Cancer 139Madhuri Rao and Andrea S. Wolf14 Anal Cancer 153Ashley J. D’Silva, Danielle S. Seiden, and Peter S. Kozuch15 Invasive Epithelial Ovarian Cancer 166Brittney S. Zimmerman, Jeanette Guziel, and Amy Tiersten16 Endometrial Cancer 181Jamal Rahaman and Carmel J. Cohen17 Cervical Cancer 194Navya Nair, Ann Marie Beddoe, and Peter Dottino18 Melanoma 204Philip Friedlander and Corazon B. Cajulis19 Sarcomas 214Robert G. Maki20 Thyroid Cancer 221Aaron M. Etra and Krzysztof Misiukiewicz21 Head and Neck Cancer 230Le Min Lee and Bruce E. Culliney22 Brain Tumors 241Rebecca M. Brown and Ad´ılia Hormigo23 Neuroendocrine Tumors 255Richard R.P. Warner, Jacob A. Martin, and Michelle K. KimPart 2: Malignant Hematology24 Myeloproliferative Neoplasms 271Sangeetha Venugopal, Daniel Aruch, and John Mascarenhas25 Myelodysplastic Syndromes 288Thomas U. Marron and Lewis R. Silverman26 Multiple Myeloma and Plasma Cell Disorders 298Siyang Leng and Ajai Chari27 Acute Myeloid Leukemia 308Kevin Barley and Shyamala C. Navada28 Acute Lymphoblastic Leukemia 319Jaclyn C. Davis and Birte Wistinghausen29 Chronic Lymphocytic Leukemia 332Adam F. Binder and Janice L. Gabrilove30 Non-Hodgkin Lymphoma 342Adam F. Binder and Joshua D. Brody31 Hodgkin Lymphoma 354Jonah Shulman, Parth R. Rao, and Akshay Sudhindra32 Primary Central Nervous System Lymphoma 364Rebecca M. Brown and Ad´ılia HormigoPart 3: BONE MARROW TRANSPLANT33 Autologous Stem Cell Transplantation for Plasma Cell Disorders 379Keren Osman34 Allogeneic Stem Cell Transplantation Overview 385Parth R. Rao, Amir Steinberg, and Luis Isola35 Allogeneic Stem Cell Transplantation for AML and MDS 392Alla Keyzner36 Stem Cell Transplantation for Lymphoproliferative Disorders 400Doyun Park, Eileen Scigliano, and Amir Steinberg37 Infectious Complications of Stem Cell Transplantation 404Meenakshi M. Rana and Amir Steinberg38 Acute Graft Versus Host Disease 412Anne S. Renteria, James L.M. Ferrara, and John E. LevinePart 4: Multidisciplinary Care of Cancer Patients39 Oncologic Emergencies 423Scot A. Niglio and Adriana K. Malone40 Thrombosis in Cancer Patients 435Doyun Park, Caroline Cromwell, Mala Varma, and Ilan Shapira41 Imaging of Cancer Patients 447Idoia Corcuera-Solano, Mathilde Wagner, and Bachir Taouli42 Overview of Radiation Oncology 454Ronald D. Ennis43 Orthopedic Oncology 463Meredith K. Bartelstein and Ilya Iofin44 Ophthalmologic Oncology 473Albert Y. Wu and Kalla A. Gervasio45 Cardio-Oncology 486Gagan Sahni46 Psychiatric and Psychologic Dimensions of Cancer Care 501Talia Wiesel47 Geriatric Oncology 514Ali John Zarrabi, Ran Huo, and Cardinale B. Smith48 Palliative Care 519Lori Spoozak and Bethann Scarborough49 Nutrition and Symptom Management 528Paula Occiano, Melissa Nagelberg, and Raquela Adelsberg50 Cancer Survivorship 535Lindsay Haines and Charles L. Shapiro51 Pediatric Cancer: Solid Tumors and Lymphoma 543Surabhi Batra and Birte Wistinghausen52 Pediatric Cancer: Brain Tumors 556Surabhi Batra and Birte WistinghausenIndex 566

EDITED BY William K. Oh, MD Chief, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York Ajai Chari, MD Associate Professor of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York SERIES EDITOR Scott L. Friedman, MD Fishberg Professor of Medicine; Dean for Therapeutic Discovery; Chief, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Select Guide Rating

• Contributors ixSeries Foreword xviiPreface xviiiList of Abbreviations xixAbout the Companion Website xxviiiPart 1: Oncology1 Breast Cancer 3Jeanette Guziel and Charles L. Shapiro2 Prostate Cancer 23Reza Mehrazin and William K. Oh3 Bladder Cancer 32Matthew D. Galsky4 Renal Cancer 43Bobby C. Liaw, Reza Mehrazin, and Che-Kai Tsao5 Testicular Cancer 56Aditya V. Shreenivas and Seth M. Cohen6 Lung Cancer 66Rajwanth Veluswamy and Jorge E. Gomez7 Malignant Mesothelioma 79Nicholas C. Rohs and Zishuo I. Hu8 Liver Cancer 89Augusto Villanueva, Myron E. Schwartz, and Josep M. Llovet9 Gallbladder/Biliary Duct Cancers 101Rajwanth Veluswamy, Anuja Kriplani, and Celina Ang10 Pancreas Cancer 111Max W. Sung11 Colorectal Cancer 118Kenneth L. Angelino, Jason W. Steinberg, and Peter S. Kozuch12 Gastric Cancer 131Sofya Pintova13 Esophageal Cancer 139Madhuri Rao and Andrea S. Wolf14 Anal Cancer 153Ashley J. D’Silva, Danielle S. Seiden, and Peter S. Kozuch15 Invasive Epithelial Ovarian Cancer 166Brittney S. Zimmerman, Jeanette Guziel, and Amy Tiersten16 Endometrial Cancer 181Jamal Rahaman and Carmel J. Cohen17 Cervical Cancer 194Navya Nair, Ann Marie Beddoe, and Peter Dottino18 Melanoma 204Philip Friedlander and Corazon B. Cajulis19 Sarcomas 214Robert G. Maki20 Thyroid Cancer 221Aaron M. Etra and Krzysztof Misiukiewicz21 Head and Neck Cancer 230Le Min Lee and Bruce E. Culliney22 Brain Tumors 241Rebecca M. Brown and Ad´ılia Hormigo23 Neuroendocrine Tumors 255Richard R.P. Warner, Jacob A. Martin, and Michelle K. KimPart 2: Malignant Hematology24 Myeloproliferative Neoplasms 271Sangeetha Venugopal, Daniel Aruch, and John Mascarenhas25 Myelodysplastic Syndromes 288Thomas U. Marron and Lewis R. Silverman26 Multiple Myeloma and Plasma Cell Disorders 298Siyang Leng and Ajai Chari27 Acute Myeloid Leukemia 308Kevin Barley and Shyamala C. Navada28 Acute Lymphoblastic Leukemia 319Jaclyn C. Davis and Birte Wistinghausen29 Chronic Lymphocytic Leukemia 332Adam F. Binder and Janice L. Gabrilove30 Non-Hodgkin Lymphoma 342Adam F. Binder and Joshua D. Brody31 Hodgkin Lymphoma 354Jonah Shulman, Parth R. Rao, and Akshay Sudhindra32 Primary Central Nervous System Lymphoma 364Rebecca M. Brown and Ad´ılia HormigoPart 3: BONE MARROW TRANSPLANT33 Autologous Stem Cell Transplantation for Plasma Cell Disorders 379Keren Osman34 Allogeneic Stem Cell Transplantation Overview 385Parth R. Rao, Amir Steinberg, and Luis Isola35 Allogeneic Stem Cell Transplantation for AML and MDS 392Alla Keyzner36 Stem Cell Transplantation for Lymphoproliferative Disorders 400Doyun Park, Eileen Scigliano, and Amir Steinberg37 Infectious Complications of Stem Cell Transplantation 404Meenakshi M. Rana and Amir Steinberg38 Acute Graft Versus Host Disease 412Anne S. Renteria, James L.M. Ferrara, and John E. LevinePart 4: Multidisciplinary Care of Cancer Patients39 Oncologic Emergencies 423Scot A. Niglio and Adriana K. Malone40 Thrombosis in Cancer Patients 435Doyun Park, Caroline Cromwell, Mala Varma, and Ilan Shapira41 Imaging of Cancer Patients 447Idoia Corcuera-Solano, Mathilde Wagner, and Bachir Taouli42 Overview of Radiation Oncology 454Ronald D. Ennis43 Orthopedic Oncology 463Meredith K. Bartelstein and Ilya Iofin44 Ophthalmologic Oncology 473Albert Y. Wu and Kalla A. Gervasio45 Cardio-Oncology 486Gagan Sahni46 Psychiatric and Psychologic Dimensions of Cancer Care 501Talia Wiesel47 Geriatric Oncology 514Ali John Zarrabi, Ran Huo, and Cardinale B. Smith48 Palliative Care 519Lori Spoozak and Bethann Scarborough49 Nutrition and Symptom Management 528Paula Occiano, Melissa Nagelberg, and Raquela Adelsberg50 Cancer Survivorship 535Lindsay Haines and Charles L. Shapiro51 Pediatric Cancer: Solid Tumors and Lymphoma 543Surabhi Batra and Birte Wistinghausen52 Pediatric Cancer: Brain Tumors 556Surabhi Batra and Birte WistinghausenIndex 566