Alex Gough, MA, VetMB, CertSAM, CertVC, PG Cert (Neuroimaging), MRCVS, is Head of Referrals at Bath Veterinary Referrals, Bath, UK. He is Vice Chair of the Clinical Board of a large veterinary group and author of numerous veterinary books, chapters and articles.Alison Thomas, BVSc, CertSAM, MRCVS, is Senior Vet at the Blue Cross Animal Hospital in Victoria, London, UK. She holds the Royal College of Veterinary Surgeons Certificate and has been awarded Advanced Practitioner status in Small Animal Medicine.Dan O'Neill, MVB BSc(hons) GPCert(SAP) GPCert(FelP) GPCert(Derm) GPCert(B&PS) MSc(VetEpi) PhD MRCVS, is Senior Lecturer in Companion Animal Epidemiology at the Royal Veterinary College in London, UK. He is a leader on the VetCompass Programme and prolific writer.

�This third edition focuses on presenting evidence about breed predispositions to increased levels of disease in purebred dogs and cats; and it seems to succeed in including all the best and most recent findings in the existing body of scientific literature. The book is therefore a must for all small animal vets, leading breeders, breed organizations and others tasked with advising on how to improve the welfare of dogs and cats through better breeding.� - Peter Sandøe �The authors have relied on 'evidence-based veterinary medicine,' i.e. a solidly scientific basis for their claims. They have enumerated the problems that arise in hundreds of breeds of dog and cat, and any person contemplating the acquisition of a purebred animal is well- advised to study this book carefully. Doing so can help assure that the animals we profess to love do not live lives of pain, suffering, disease and misery.� - Bernard E. Rollin

• Author Biographies xiForeword xiiiPreface xvAbbreviations xviiIntroduction 1Basic and Clinical Genetics 1Epidemiology 7Longevity 10Methods 14Part I: Dog Breeds 17Affenpinscher 19Afghan Hound 19African Boerboel 20Airedale Terrier 20Akbash 21Akita Inu 21Alaskan Husky 21Alaskan Klee Kai 21Alaskan Malamute 21Alsatian 22American Bulldog 22American Cocker Spaniel 22American Eskimo 22American Pit Bull Terrier 22American Staffordshire Terrier 23Anatolian Shepherd Dog 24Australian Cattle Dog 24Australian Kelpie 25Australian Shepherd Dog 25Australian Silky Terrier 26Australian Terrier 27Basenji 27Basset Hound 28Beagle 29Bearded Collie 31Beauceron 32Bedlington Terrier 32Belgian Shepherd Dog 32Berger Blanc Suisse 32Bernese Mountain Dog 33Bichon Frise 34Bloodhound 35Bolognese 36Bolonka Zwetna 36Border Collie 36Border Terrier 38Borzoi 38Boston Terrier 39Bouvier Des Flandres 40Boxer 41Boykin Spaniel 46Briard 46British Bulldog 46Brittany Spaniel 46Brussels Griffon 47Buhund 47Bull Terrier 47Bull Terrier – Miniature 48Bulldog – American 49Bulldog – English 49Bullmastiff 51Cairn Terrier 52Cane Corso 53Catahoula Leopard Dog 53Cavalier King Charles Spaniel 54Chesapeake Bay Retriever 56Chihuahua 56Chin 57Chinese Crested Dog 58Chinese Shar Pei 58Chow Chow 58Clumber Spaniel 59Cocker Spaniel 60Collies – Rough and Smooth 64Coonhound 66Corgi 66Coton De Tulear 66Curly‐Coated Retriever 67Dachshund 67Dalmatian 70Dandie Dinmont Terrier 72Danish Chicken Dog 72Danish/Swedish Farmdog 72Deerhound 72Deutscher Wachtelhund 72Dobermann Pinscher 72Dogo Argentino 76Dogue De Bordeaux 77Dutch Partridge Dog 77Dutch Sheepdog 77Dutch Spaniel 77Elkhound 77English Bulldog 77English Cocker Spaniel 78English Setter 78English Shepherd 79English Springer Spaniel 79English Toy Spaniel 79Entlebucher Mountain Dog 79Eskimo Dog 79Estrela Mountain Dog 80Finnish Hound 80Finnish Lapphund 80Finnish Spitz 80Flat‐Coated Retriever 80Fox Terrier 81Foxhound 83French Alpine Mastiff 83French Bulldog 83French Mastiff 85French Spaniel 85Frisian Water Dog 85Galgos Español 85German Pinscher 85German Shepherd Dog 85German Spaniel 93Glen of Imaal Terrier 93Golden Retriever 93Gordon Setter 99Grand Bleu De Gascogne Hound 100Great Dane 100Great Pyrenees 104Greater Swiss Mountain Dog 104Greyhound 104Greyhound – Spanish 107Griffon Bruxellois 107Hamilton Hound 107Havanese 108Hokkaido 108Hovawart 108Hungarian Kuvasz 109Hungarian Puli 110Hungarian Vizsla 110Hungarian Water Dog 111Husky 111Irish Red and White Setter 111Irish Setter 111Irish Terrier 113Irish Water Spaniel 114Irish Wolfhound 114Italian Greyhound 116Italian Mastiff 116Italian Spinone 116Jack Russell Terrier 117Jämthund 119Japanese Akita Inu 119Japanese Chin 121Japanese Shiba Inu 121Japanese Tosa 121Jindo 122Keeshond 122Kelpie 123Kerry Blue Terrier 123King Charles Spaniel 123Klee Kai 124Kooiker Dog 124Korean Jindo 124Kromfohrländer 124Kuvasz 124Labrador Retriever 124Lakeland Terrier 131Lancashire Heeler 131Lapland Reindeer Dog 131Lapphund 131Leonberger 131Lhasa Apso 132Lowchen 134Mah Thai 134Malamute 134Maltese 134Manchester Terrier 136Mastiff 136Mastiff (Unspecified) 136Mcnab Shepherd 137Mexican Hairless 138Miniature Bull Terrier 138Miniature Pinscher 138Mountain Dog 139Münsterländer – Pointer 139Neapolitan Mastiff 139New Zealand Huntaway 140Newfoundland 140Norfolk Terrier 142Norwegian Buhund 143Norwegian Elkhound 143Norwegian Lundehund 144Norwegian Sheepdog 144Norwich Terrier 145Nova Scotia Duck Tolling Retriever 145Ogar Polski 146Old English Mastiff 146Old English Sheepdog 146Otterhound 147Papillon 147Parson Russell Terrier 148Pekingese 149Petit Basset Griffon Vendeen 150Phu Quoc Ridgeback 151Pinscher – Miniature 151Pointer 151Polish Hound 154Polish Lowland Sheepdog 154Pomeranian 154Poodle (Unspecified Variant) 156Poodle – Miniature 158Poodle – Standard 161Poodle – Toy 162Portuguese Podengo Pequeno 164Portuguese Water Dog 164Presa Canario 165Pug 165Puli 168Pyrenean Mountain Dog 168Pyrenean Shepherd 169Rat Terrier 170Red and White Setter 170Red Kelpie 170Red Setter 170Retriever 170Rhodesian Ridgeback 170Rottweiler 172Rough Collie 177Russian Black Terrier 177St Bernard 177Saluki 179Samoyed 179Savoy Sheepdog 180Schapendoes 180Schipperke 181Schnauzer (Unspecified Variant) 181Schnauzer – Giant 181Schnauzer – Miniature 183Schnauzer – Standard 187Scottish Deerhound 187Scottish Terrier 188Sealyham Terrier 190Sennenhund 190Shar Pei 190Shetland Sheepdog 192Shiba Inu 195Shih Tzu 195Siberian Husky 198Silken Windhound 199Silky Terrier 199Skye Terrier 199Sloughi 200Smooth Collie 200Soft‐Coated Wheaten Terrier 200Spanish Greyhound 201Spanish Mastiff 201Spanish Water Dog 201Spinone Italiano 201Springer Spaniel 201Staffordshire Bull Terrier 204Staffordshire Bull Terrier – American 206Sussex Spaniel 206Swedish Cattle Dog 206Swedish Elkhound 206Swedish Farmdog 207Swedish Lapphund 207Swedish Vallhund 207Swiss Mountain Dog 207Tenterfield Terrier 208Thai Ridgeback 208Tibetan Mastiff 208Tibetan Spaniel 209Tibetan Terrier 209Tosa 210Treeing Walker Coonhound 210Turkish Shepherd Dog 210Vallhund 211Vizsla 211Vorstehhund 211Wachtelhund 211Weimaraner 211Welsh Corgi 213Welsh Springer Spaniel 214Welsh Terrier 214West Highland White Terrier 215Wetterhoun 218Whippet 218White Swiss Shepherd Dog 219Wolfhound – Irish 220Wolfspitz 220Yorkshire Terrier 220Part II: Cat Breeds 225Abyssinian 227American Shorthair 229Asian 229Australian Mist 229Balinese 229Bengal 230Birman 231British Shorthair 232Burmese 233Chartreux 236Chinchilla 236Colourpoint Persian 236Cornish Rex 236Devon Rex 236Egyptian Mau 237European Shorthair 237Exotic Shorthair 238Foreign Shorthair 238Foreign White 238Havana Brown 238Himalayan 239Japanese Bobtail 240Javanese 240Korat 240La Perm 241Maine Coon 241Manx 242Norwegian Forest Cat 243Ocicat 244Oriental Shorthair 244Persian 245Ragdoll 247Russian Blue 249Savannah 249Scottish Fold 249Seychellois 249Siamese 249Siberian Forest Cat 253Singapura 253Snowshoe 253Somali 254Sphynx 254Tonkinese 255Turkish Angora 255Turkish Van 255Part III: Disease Descriptions 257References 305

Alex Gough, MA, VetMB, CertSAM, CertVC, PG Cert (Neuroimaging), MRCVS, is Head of Referrals at Bath Veterinary Referrals, Bath, UK. He is Vice Chair of the Clinical Board of a large veterinary group and author of numerous veterinary books, chapters and articles.Alison Thomas, BVSc, CertSAM, MRCVS, is Senior Vet at the Blue Cross Animal Hospital in Victoria, London, UK. She holds the Royal College of Veterinary Surgeons Certificate and has been awarded Advanced Practitioner status in Small Animal Medicine.Dan O'Neill, MVB BSc(hons) GPCert(SAP) GPCert(FelP) GPCert(Derm) GPCert(B&PS) MSc(VetEpi) PhD MRCVS, is Senior Lecturer in Companion Animal Epidemiology at the Royal Veterinary College in London, UK. He is a leader on the VetCompass Programme and prolific writer.

�This third edition focuses on presenting evidence about breed predispositions to increased levels of disease in purebred dogs and cats; and it seems to succeed in including all the best and most recent findings in the existing body of scientific literature. The book is therefore a must for all small animal vets, leading breeders, breed organizations and others tasked with advising on how to improve the welfare of dogs and cats through better breeding.� - Peter Sandøe �The authors have relied on 'evidence-based veterinary medicine,' i.e. a solidly scientific basis for their claims. They have enumerated the problems that arise in hundreds of breeds of dog and cat, and any person contemplating the acquisition of a purebred animal is well- advised to study this book carefully. Doing so can help assure that the animals we profess to love do not live lives of pain, suffering, disease and misery.� - Bernard E. Rollin

• Author Biographies xiForeword xiiiPreface xvAbbreviations xviiIntroduction 1Basic and Clinical Genetics 1Epidemiology 7Longevity 10Methods 14Part I: Dog Breeds 17Affenpinscher 19Afghan Hound 19African Boerboel 20Airedale Terrier 20Akbash 21Akita Inu 21Alaskan Husky 21Alaskan Klee Kai 21Alaskan Malamute 21Alsatian 22American Bulldog 22American Cocker Spaniel 22American Eskimo 22American Pit Bull Terrier 22American Staffordshire Terrier 23Anatolian Shepherd Dog 24Australian Cattle Dog 24Australian Kelpie 25Australian Shepherd Dog 25Australian Silky Terrier 26Australian Terrier 27Basenji 27Basset Hound 28Beagle 29Bearded Collie 31Beauceron 32Bedlington Terrier 32Belgian Shepherd Dog 32Berger Blanc Suisse 32Bernese Mountain Dog 33Bichon Frise 34Bloodhound 35Bolognese 36Bolonka Zwetna 36Border Collie 36Border Terrier 38Borzoi 38Boston Terrier 39Bouvier Des Flandres 40Boxer 41Boykin Spaniel 46Briard 46British Bulldog 46Brittany Spaniel 46Brussels Griffon 47Buhund 47Bull Terrier 47Bull Terrier – Miniature 48Bulldog – American 49Bulldog – English 49Bullmastiff 51Cairn Terrier 52Cane Corso 53Catahoula Leopard Dog 53Cavalier King Charles Spaniel 54Chesapeake Bay Retriever 56Chihuahua 56Chin 57Chinese Crested Dog 58Chinese Shar Pei 58Chow Chow 58Clumber Spaniel 59Cocker Spaniel 60Collies – Rough and Smooth 64Coonhound 66Corgi 66Coton De Tulear 66Curly‐Coated Retriever 67Dachshund 67Dalmatian 70Dandie Dinmont Terrier 72Danish Chicken Dog 72Danish/Swedish Farmdog 72Deerhound 72Deutscher Wachtelhund 72Dobermann Pinscher 72Dogo Argentino 76Dogue De Bordeaux 77Dutch Partridge Dog 77Dutch Sheepdog 77Dutch Spaniel 77Elkhound 77English Bulldog 77English Cocker Spaniel 78English Setter 78English Shepherd 79English Springer Spaniel 79English Toy Spaniel 79Entlebucher Mountain Dog 79Eskimo Dog 79Estrela Mountain Dog 80Finnish Hound 80Finnish Lapphund 80Finnish Spitz 80Flat‐Coated Retriever 80Fox Terrier 81Foxhound 83French Alpine Mastiff 83French Bulldog 83French Mastiff 85French Spaniel 85Frisian Water Dog 85Galgos Español 85German Pinscher 85German Shepherd Dog 85German Spaniel 93Glen of Imaal Terrier 93Golden Retriever 93Gordon Setter 99Grand Bleu De Gascogne Hound 100Great Dane 100Great Pyrenees 104Greater Swiss Mountain Dog 104Greyhound 104Greyhound – Spanish 107Griffon Bruxellois 107Hamilton Hound 107Havanese 108Hokkaido 108Hovawart 108Hungarian Kuvasz 109Hungarian Puli 110Hungarian Vizsla 110Hungarian Water Dog 111Husky 111Irish Red and White Setter 111Irish Setter 111Irish Terrier 113Irish Water Spaniel 114Irish Wolfhound 114Italian Greyhound 116Italian Mastiff 116Italian Spinone 116Jack Russell Terrier 117Jämthund 119Japanese Akita Inu 119Japanese Chin 121Japanese Shiba Inu 121Japanese Tosa 121Jindo 122Keeshond 122Kelpie 123Kerry Blue Terrier 123King Charles Spaniel 123Klee Kai 124Kooiker Dog 124Korean Jindo 124Kromfohrländer 124Kuvasz 124Labrador Retriever 124Lakeland Terrier 131Lancashire Heeler 131Lapland Reindeer Dog 131Lapphund 131Leonberger 131Lhasa Apso 132Lowchen 134Mah Thai 134Malamute 134Maltese 134Manchester Terrier 136Mastiff 136Mastiff (Unspecified) 136Mcnab Shepherd 137Mexican Hairless 138Miniature Bull Terrier 138Miniature Pinscher 138Mountain Dog 139Münsterländer – Pointer 139Neapolitan Mastiff 139New Zealand Huntaway 140Newfoundland 140Norfolk Terrier 142Norwegian Buhund 143Norwegian Elkhound 143Norwegian Lundehund 144Norwegian Sheepdog 144Norwich Terrier 145Nova Scotia Duck Tolling Retriever 145Ogar Polski 146Old English Mastiff 146Old English Sheepdog 146Otterhound 147Papillon 147Parson Russell Terrier 148Pekingese 149Petit Basset Griffon Vendeen 150Phu Quoc Ridgeback 151Pinscher – Miniature 151Pointer 151Polish Hound 154Polish Lowland Sheepdog 154Pomeranian 154Poodle (Unspecified Variant) 156Poodle – Miniature 158Poodle – Standard 161Poodle – Toy 162Portuguese Podengo Pequeno 164Portuguese Water Dog 164Presa Canario 165Pug 165Puli 168Pyrenean Mountain Dog 168Pyrenean Shepherd 169Rat Terrier 170Red and White Setter 170Red Kelpie 170Red Setter 170Retriever 170Rhodesian Ridgeback 170Rottweiler 172Rough Collie 177Russian Black Terrier 177St Bernard 177Saluki 179Samoyed 179Savoy Sheepdog 180Schapendoes 180Schipperke 181Schnauzer (Unspecified Variant) 181Schnauzer – Giant 181Schnauzer – Miniature 183Schnauzer – Standard 187Scottish Deerhound 187Scottish Terrier 188Sealyham Terrier 190Sennenhund 190Shar Pei 190Shetland Sheepdog 192Shiba Inu 195Shih Tzu 195Siberian Husky 198Silken Windhound 199Silky Terrier 199Skye Terrier 199Sloughi 200Smooth Collie 200Soft‐Coated Wheaten Terrier 200Spanish Greyhound 201Spanish Mastiff 201Spanish Water Dog 201Spinone Italiano 201Springer Spaniel 201Staffordshire Bull Terrier 204Staffordshire Bull Terrier – American 206Sussex Spaniel 206Swedish Cattle Dog 206Swedish Elkhound 206Swedish Farmdog 207Swedish Lapphund 207Swedish Vallhund 207Swiss Mountain Dog 207Tenterfield Terrier 208Thai Ridgeback 208Tibetan Mastiff 208Tibetan Spaniel 209Tibetan Terrier 209Tosa 210Treeing Walker Coonhound 210Turkish Shepherd Dog 210Vallhund 211Vizsla 211Vorstehhund 211Wachtelhund 211Weimaraner 211Welsh Corgi 213Welsh Springer Spaniel 214Welsh Terrier 214West Highland White Terrier 215Wetterhoun 218Whippet 218White Swiss Shepherd Dog 219Wolfhound – Irish 220Wolfspitz 220Yorkshire Terrier 220Part II: Cat Breeds 225Abyssinian 227American Shorthair 229Asian 229Australian Mist 229Balinese 229Bengal 230Birman 231British Shorthair 232Burmese 233Chartreux 236Chinchilla 236Colourpoint Persian 236Cornish Rex 236Devon Rex 236Egyptian Mau 237European Shorthair 237Exotic Shorthair 238Foreign Shorthair 238Foreign White 238Havana Brown 238Himalayan 239Japanese Bobtail 240Javanese 240Korat 240La Perm 241Maine Coon 241Manx 242Norwegian Forest Cat 243Ocicat 244Oriental Shorthair 244Persian 245Ragdoll 247Russian Blue 249Savannah 249Scottish Fold 249Seychellois 249Siamese 249Siberian Forest Cat 253Singapura 253Snowshoe 253Somali 254Sphynx 254Tonkinese 255Turkish Angora 255Turkish Van 255Part III: Disease Descriptions 257References 305