Human Metabolism

Keith N. Frayn, Emeritus Professor of Human Metabolism, University of Oxford, UK. Rhys D. Evans, Reader in Metabolic Biochemistry, Department of Physiology, Anatomy and Genetics, University of Oxford, UK.

Praise for the 4th edition"Frayn and Evans have done a marvellous job of updating this textbook to reflect recent developments in metabolic research ... I now have the relatively simple task of updating my reading list for this coming year's lectures to recommend this terrific new edition." (Physiology News Autumn 2019, Issue 116) "This textbook has been a masterpiece since the first edition ... by giving a superb explanation of human metabolism to range a wide readers and students. “Human Metabolism” has remained a favorite reference for many teachers of students of a variety of medical programs be it medicine, nursing or biochemistry ... With each edition the book has improved by providing up to date information in a key and basic field of medicine where knowledge has been moving very fast in the last 25 years." (Clinical Nutrition)“Based on its highly regarded predecessor – Metabolic Regulation: A Human Perspective – this book has been given a noticeable overhaul in both content and title. Unlike the many other texts available that are dominated by the intricacies of biochemistry, this book seeks to offer readers from clinical and sports science backgrounds practical insights into human metabolism ... The authors’ relaxed writing styles make reading about complex themes interesting and, dare I say it, fun ... The readability also extends to the layout, which is uncluttered and easy to navigate. Abundant colourful diagrams interspersed throughout succeed in consolidating the knowledge conveyed narratively in the text ... Human Metabolism is undoubtedly a highly readable resource that will have broad appeal for those with an interest in physiology and nutrition. Overall, I would certainly recommend it as a useful addition to any trainee’s library.” (The Bulletin of the Royal College of Pathologists) Praise for the previous edition“I had the great pleasure of reading your impressive text. While I realize that your intended market is certainly not people such as myself (I read it to better understand my own health and body), it is surprisingly well suited for that purpose: being both dense in useful information and surprisingly accessible to non-specialist readers.  I appreciated several things about your book -- that you kept the text relatively short for an academic text; that you made it largely self-contained (I especially appreciate your care in providing internal cross references in the book); that you put much of the content into tables, boxes, and diagrams … I learned a great deal from the book, and it has substantially increased the quality of my interactions with my own physician” (Doug Tygar, Professor of Computer Science & Information, UC Berkeley, USA)"It is hard to find a textbook that gives a better basis for the understanding of Human metabolism and nutrition, that is so well designed and actually quite fun to read as this one. This book is my first choice for a textbook for my medical students and for nursing school too. It is well suited for any kind of studies of metabolism at a higher level because of its ease at explaining the basics and the frameworks needed for the understanding of metabolism. It is the first book I give to my doctorial students when they need to freshen up their knowledge and the basics in metabolism when starting research in clinical nutrition and metabolism...if anyone is looking for the most interesting and fun book to read as an in depth introduction to human metabolism and nutrition, this is it!" (Clinical Nutrition)

• Preface viAbbreviations viiAbout the companion website xi1 The underlying principles of human metabolism 12 Cellular aspects of metabolic regulation 483 Coordination of metabolism in the whole body 764 Digestion and intestinal absorption 935 Metabolic specialisation of organs and tissues 1186 Communication systems 1737 Integration of carbohydrate, fat and protein metabolism in normal daily life 2048 Metabolic challenges: Coping with some extreme physiological situations 2459 Metabolic challenges: Coping with some pathological situations 27710 Lipoprotein metabolism and atherosclerosis 30211 Energy balance and body weight regulation 32512 Diabetes mellitus 346Index 365