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Beskrivning
The current volume continues the tradition of the Organic Syntheses series, providing carefully checked and edited experimental procedures that describe important synthetic methods, transformations, reagents, and synthetic building blocks or intermediates with demonstrated utility in organic synthesis. These significant and interesting procedures should prove worthwhile to many synthetic chemists working in increasingly diverse areas. A trusted guide for professionals in organic and medicinal chemistry in academia, government, and industries, including pharmaceuticals, fine chemicals, agrochemicals, and biotechnological products.
Produktinformation
- Utgivningsdatum:2018-09-14
- Mått:158 x 229 x 28 mm
- Vikt:862 g
- Format:Inbunden
- Språk:Engelska
- Serie:Organic Syntheses
- Antal sidor:448
- Förlag:John Wiley & Sons Inc
- ISBN:9781119511946
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Margaret M. Faul received her B.Sc. and M.Sc degrees from University College Dublin, Ireland. She then moved to the US where she received her Ph.D. degree in synthetic organic chemistry from Harvard University with Professor David A. Evans. In 1993 Margaret joined the Chemical Process group at Eli Lilly and Company, and in 2003 she moved to Amgen where she is currently the Executive Director in the Process Development organization. At Amgen, Margaret is responsible for the commercial process development and process characterization of all molecules in both the synthetic and biologic Amgen portfolio.
Innehållsförteckning
- Preparation of Aryl Alkyl Ketenes 1Nicholas D. Staudaher, Joseph Lovelace, Michael P. Johnson, and Janis LouiePreparation of Diisopropylammonium Bis(catecholato)cyclohexylsilicate 16Kingson Lin, Christopher B. Kelly, Matthieu Jouffroy, and Gary A.MolanderContinuous Flow Hydration of Pyrazine-2-carbonitrile in a Manganese Dioxide Column Reactor 34Claudio Battilocchio, Shing-Hing Lau, Joel M. Hawkins, and Steven V. LeySite-Selective C-H Fluorination of Pyridines and Diazines with AgF2 46Patrick S. Fier and John F. HartwigSite-Selective C-H Fluorination of Pyridines and Diazines with AgF2 46Patrick S. Fier and John F. HartwigUgi Multicomponent Reaction 54André Boltjes, Haixia Liu, Haiping Liu, and Alexander DömlingPalladium-catalyzed External-CO-Free Reductive Carbonylation of Bromoarenes 66Hideyuki Konishi, Masataka Fukuda, Tsuyoshi Ueda, and Kei ManabePractical Syntheses of [2,2′-bipyridine]bis[3,5-difluoro-2- [5-(trifluoromethyl)-2 pyridinyl]phenyl]iridium(III) hexafluorophosphate, [Ir{dF(CF3)ppy}2(bpy)]PF6 and [4,4′-bis (tert-butyl) 2,2′-bipyridine]bis[3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl]phenyl]iridium(III) hexafluorophosphate, [Ir{dF(CF3)ppy}2 (dbbpy)]PF6 77Martins S. Oderinde and Jeffrey W. Johannes (Z)-Enol p-Tosylate Derived from Methyl Acetoacetate: A Useful Cross-coupling Partner for the Synthesis of Methyl (Z)-3-Phenyl (or Aryl)-2-butenoate 93Yuichiro Ashida, Hidefumi Nakatsuji, and Yoo TanabeSynthesis of Allenyl Mesylate by a Johnson-Claisen Rearrangement. Preparation of 3-(((tert-butyldiphenyl- silyl)oxy)methyl)penta-3,4-dien-1-yl methanesulfonate 109Joseph E. Burchick. Jr., Sarah M. Wells, and Kay M. BrummondRhodium(I)-catalyzed Allenic Pauson–Khand Reaction 123Joseph E. Burchick. Jr., Sarah M. Wells, and Kay M. BrummondDirhodium (II) tetrakis[N-4-bromo-1,8-naphthoyl-(S)-tert-leucinate] 136Hélène Lebel, Henri Piras, and Johan BartholoméüsButa-2,3-dien-1-ol 153Hongwen Luo, Dengke Ma, and Shengming MaFragment Coupling and Formation of Quaternary Carbons by Visible-Light Photoredox Catalyzed Reaction of tert-Alkyl Hemioxalate Salts and Michael Acceptors 167Christopher R. Jamison, Yuriy Slutskyy, and Larry E. OvermanN-Methoxy-N-methylcyanoformamide 184Jeremy Nugent and Brett D. Schwartz4-Cyano-2-methoxybenzenesulfonyl Chloride 198Elliott D. Bayle, Niall Igoe, and Paul V. FishPreparation of N-Trifluoromethylthiosaccharin: A Shelf-Stable Electrophilic Reagent for Trifluoromethylthiolation 217Jiansheng Zhu, Chunhui Xu, Chunfa Xu, and Qilong ShenHomologation of Boronic Esters with Lithiated Epoxides 234Roly J. Armstrong and Varinder K. AggarwalAsymmetric Michael Reaction of Aldehydes and Nitroalkenes 252Yujiro Hayashi and Shin OgasawaraPreparation of anti-1,3-Amino Alcohol Derivatives Through an Asymmetric Aldol-Tishchenko Reaction of Sulfinimines 259Pamela Mackey, Rafael Cano, Vera M. Foley, and Gerard P. McGlackenRhenium-Catalyzed ortho-Alkylation of Phenols 280Yoichiro Kuninobu, Masaki, Yamamoto, Mitsumi Nishi, Tomoyuki Yamamoto, Takashi Matsuki, Masahito Murai, and Kazuhiko TakaiEnantioselective Preparation of 5-Oxo-5,6-dihydro-2H-pyran-2-yl phenylacetate via organocatalytic Dynamic Kinetic Asymmetric Transformation (DyKAT) 292Tamas Benkovics, Adrian Ortiz, Gregory L. Beutner, and Chris SfouggatakisPreparation of Sodium Heptadecyl Sulfate (Tergitol-7i) 303Brent A. Banasik and Mansour SamadpourCatalytic Enantioselective Addition of Diethyl Phosphite to N-Thiophosphinoyl Ketimines: Preparation of (R)-Diethyl (1-Amino-1-phenylethyl)phosphonate 313Shaoquan Lin, Yasunari Otsuka, Liang Yin, Naoya Kumagai, and Masakatsu ShibasakiWater-promoted, Open-flask Synthesis of Amine-boranes: 2-Methylpyridine-borane (2-Picoline-borane) 332Ameya S. Kulkarni and P. Veeraraghavan RamachandranPreparation of N-Sulfinyl Aldimines using Pyrrolidine as Catalyst via Iminium Ion Activation 346Sara Morales, Alfonso García Rubia, Eduardo Rodrigo, José Luis Aceña, José Luis García Ruano, and M. Belén CidSynthesis of N-Boc-N-Hydroxymethyl-L-phenylalaninal 358Jae Won Yoo, Youngran Seo, Dongwon Yoo, and Young Gyu KimSynthesis of Methyl trans-Oxazolidine-5-carboxylate, a Chiral Synthon for threo-β-Amino-α-hydroxy Acid 372Youngran Seo, Jae Won Yoo, Yoonjae Lee, Boram Lee, Bonghyun Kim, and Young Gyu KimPreparation of Benzyl((R)-2-(4-(benzyloxy)phenyl)-2-((tert- butoxycarbonyl)amino)acetyl)-D-phenylalaninate using Umpolung Amide Synthesis 388Matthew T. Knowe, Sergey V. Tsukanov, and Jeffrey N. Johnston