GEORGE OSOL, PhD, is Professor Emeritus in the Department of Obstetrics, Gynecology and Reproductive Sciences at the University of Vermont Larner College of Medicine, Burlington, VT, USA; a University Scholar and an Established Investigator of the American Heart Association, specializing in vascular physiology and preeclampsia.

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• Acknowledgement ixKey Concepts and Terms xiIntroduction 1 1 The Adult Male 31.1 Three Basic Requirements for Fertility in the Male 31.2 Endocrinology of the Male Reproductive System 41.3 Physiological Actions of Testosterone and Related Androgens 81.4 Spermatogenesis and Spermiogenesis 111.5 Production of Seminal Plasma 151.6 Testicular Thermoregulation; Varicocoele 161.7 Penile Erection 181.8 Cellular Mechanism of PDE-5 Inhibitors in Treating Erectile Dysfunction 201.9 Emission and Ejaculation 211.10 Infertility 222 The Nonpregnant Adult Female 25 2.1 The Menstrual Cycle: A Perspective 252.2 Oogenesis 26 2.3 Folliculogenesis 282.4 Follicular Production of Sex Steroid Hormones 312.5 Recruitment of the Dominant Follicle 322.6 Transition from the Follicular to the Ovulatory Phase: The LH Surge 332.7 The Luteal Phase 352.8 Corresponding Uterine Phases: Menstrual, Proliferative, Secretory 362.9 Estrogen 392.10 Progesterone 402.11 Putting It Together 413 Pregnancy, Parturition, Lactation 45 3.1 Fertilization and Early Embryogenesis 453.2 Implantation 513.3 Multiple Births 533.4 Placentation 543.5 The Endocrinology of Pregnancy 593.6 Prenatal Testing for Fetal Aneuplody and Other Maternal and Fetal Conditions 613.7 Maternal Adaptations During Pregnancy 633.8 Embryonic and Fetal Growth 653.9 Labor and Parturition 653.10 Lactation and Breastfeeding 683.11 Long-Term Health Effects of Pregnancy on Mother and Child 714 The Human Sexual Response 73 4.1 Desire Phase 734.2 Excitement Phase 744.3 Plateau Phase 754.4 Orgasmic Phase 754.5 Resolution Phase 775 Age-Related Changes in the Reproductive System 79 5.1 Childhood and Adolescence 795.2 Puberty 815.3 The Aging Male and Female 81Appendix A: Detailed Anatomy of the Male and Female Reproductive Systems 83Index 87

GEORGE OSOL, PhD, is Professor Emeritus in the Department of Obstetrics, Gynecology and Reproductive Sciences at the University of Vermont Larner College of Medicine, Burlington, VT, USA; a University Scholar and an Established Investigator of the American Heart Association, specializing in vascular physiology and preeclampsia.

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• Acknowledgement ixKey Concepts and Terms xiIntroduction 1 1 The Adult Male 31.1 Three Basic Requirements for Fertility in the Male 31.2 Endocrinology of the Male Reproductive System 41.3 Physiological Actions of Testosterone and Related Androgens 81.4 Spermatogenesis and Spermiogenesis 111.5 Production of Seminal Plasma 151.6 Testicular Thermoregulation; Varicocoele 161.7 Penile Erection 181.8 Cellular Mechanism of PDE-5 Inhibitors in Treating Erectile Dysfunction 201.9 Emission and Ejaculation 211.10 Infertility 222 The Nonpregnant Adult Female 25 2.1 The Menstrual Cycle: A Perspective 252.2 Oogenesis 26 2.3 Folliculogenesis 282.4 Follicular Production of Sex Steroid Hormones 312.5 Recruitment of the Dominant Follicle 322.6 Transition from the Follicular to the Ovulatory Phase: The LH Surge 332.7 The Luteal Phase 352.8 Corresponding Uterine Phases: Menstrual, Proliferative, Secretory 362.9 Estrogen 392.10 Progesterone 402.11 Putting It Together 413 Pregnancy, Parturition, Lactation 45 3.1 Fertilization and Early Embryogenesis 453.2 Implantation 513.3 Multiple Births 533.4 Placentation 543.5 The Endocrinology of Pregnancy 593.6 Prenatal Testing for Fetal Aneuplody and Other Maternal and Fetal Conditions 613.7 Maternal Adaptations During Pregnancy 633.8 Embryonic and Fetal Growth 653.9 Labor and Parturition 653.10 Lactation and Breastfeeding 683.11 Long-Term Health Effects of Pregnancy on Mother and Child 714 The Human Sexual Response 73 4.1 Desire Phase 734.2 Excitement Phase 744.3 Plateau Phase 754.4 Orgasmic Phase 754.5 Resolution Phase 775 Age-Related Changes in the Reproductive System 79 5.1 Childhood and Adolescence 795.2 Puberty 815.3 The Aging Male and Female 81Appendix A: Detailed Anatomy of the Male and Female Reproductive Systems 83Index 87

GEORGE OSOL, PhD, is Professor Emeritus in the Department of Obstetrics, Gynecology and Reproductive Sciences at the University of Vermont Larner College of Medicine, Burlington, VT, USA; a University Scholar and an Established Investigator of the American Heart Association, specializing in vascular physiology and preeclampsia.

Select Guide Rating

• Acknowledgement ixKey Concepts and Terms xiIntroduction 1 1 The Adult Male 31.1 Three Basic Requirements for Fertility in the Male 31.2 Endocrinology of the Male Reproductive System 41.3 Physiological Actions of Testosterone and Related Androgens 81.4 Spermatogenesis and Spermiogenesis 111.5 Production of Seminal Plasma 151.6 Testicular Thermoregulation; Varicocoele 161.7 Penile Erection 181.8 Cellular Mechanism of PDE-5 Inhibitors in Treating Erectile Dysfunction 201.9 Emission and Ejaculation 211.10 Infertility 222 The Nonpregnant Adult Female 25 2.1 The Menstrual Cycle: A Perspective 252.2 Oogenesis 26 2.3 Folliculogenesis 282.4 Follicular Production of Sex Steroid Hormones 312.5 Recruitment of the Dominant Follicle 322.6 Transition from the Follicular to the Ovulatory Phase: The LH Surge 332.7 The Luteal Phase 352.8 Corresponding Uterine Phases: Menstrual, Proliferative, Secretory 362.9 Estrogen 392.10 Progesterone 402.11 Putting It Together 413 Pregnancy, Parturition, Lactation 45 3.1 Fertilization and Early Embryogenesis 453.2 Implantation 513.3 Multiple Births 533.4 Placentation 543.5 The Endocrinology of Pregnancy 593.6 Prenatal Testing for Fetal Aneuplody and Other Maternal and Fetal Conditions 613.7 Maternal Adaptations During Pregnancy 633.8 Embryonic and Fetal Growth 653.9 Labor and Parturition 653.10 Lactation and Breastfeeding 683.11 Long-Term Health Effects of Pregnancy on Mother and Child 714 The Human Sexual Response 73 4.1 Desire Phase 734.2 Excitement Phase 744.3 Plateau Phase 754.4 Orgasmic Phase 754.5 Resolution Phase 775 Age-Related Changes in the Reproductive System 79 5.1 Childhood and Adolescence 795.2 Puberty 815.3 The Aging Male and Female 81Appendix A: Detailed Anatomy of the Male and Female Reproductive Systems 83Index 87