Bladder Pathology

Liang Cheng, MD, MS, is Professor and Vice Chair of Pathology, Professor of Surgery/Urology, Director of Anatomic Pathology, Director of Molecular Pathology in the Department of Pathology and Laboratory Medicine at the Brown University Warren Alpert Medical School and Brown University Health, Providence, Rhode Island. He also serves as the Associate Director of the Legorreta Cancer Center at Brown University. Dr. Cheng has published over 1,200 peer-reviewed SCI articles (h-index: 133) in high-impact scientific journals. He has been honored with prestigious awards, including the Arthur Purdy Stout Annual Award from the Society of Surgical Pathologists for his outstanding contributions to surgical pathology and the Koss Medal Award from the International Society of Urological Pathology (ISUP) for lifetime achievement in urological pathology. Dr. Cheng is the incoming President (2025-2027) of the International Society of Urological Pathology. Antonio Lopez-Beltran, MD, PhD, is Professor of Anatomic Pathology, Department of Morphological Sciences, Cordoba University Medical School, Cordoba, Spain. Antonio’s work is centered in genitourinary tumor pathology with emphasis on pathology of the urinary bladder. He is Past Chairman of the European Section of Uropathology of the European Association of Urology and Past Chairman of the Uropathology Working Group of the European Society of Pathology. He serves on the editorial boards of several international pathology journals. Rodolfo Montironi, MD, IFCAP, is Professor of Anatomic Pathology, Molecular Medicine and Cell Therapy Foundation, Polytechnic University of the Marche Region, Italy. Rodolfo’s work is centered in genitourinary tumor pathology. He is a Past President of the International Society of Urological Pathology. He serves on the editorial boards of several international pathology and urology journals, including European Urology.

• Preface vii1 Normal Anatomy and Histology 12 Inflammatory and Infectious Conditions 193 Urothelial Metaplasia and Hyperplasia 474 Polyps and Other Nonneoplastic Benign Conditions 755 Benign Epithelial Tumors 916 Flat Urothelial Lesions with Atypia and Urothelial Dysplasia 1057 Urothelial Carcinoma In Situ 1218 Bladder Cancer: General Features 1479 Classification and Grading of Bladder Cancer 17510 Stage pT1 Urothelial Carcinoma 20911 Staging of Bladder Cancer 24112 Histological Variants (Subtypes) of Urothelial Carcinoma 26313 Bladder Tumors with Inverted Growth 31114 Bladder Carcinoma in Specific Clinical Setting 32915 Sarcomatoid Carcinoma (Carcinosarcoma) 34516 Adenocarcinoma and Its Putative Precursors and Variants 37317 Squamous Cell Carcinoma and Other Squamous Lesions 39718 Neuroendocrine Tumors 41519 Handling and Reporting of Bladder Specimens 44920 Congenital Disorders and Pediatric Neoplasms 47321 Soft Tissue Tumors 49722 Lymphoid and Hematopoietic Tumors 53723 Other Rare Tumors 54724 Secondary Tumors 56125 Treatment Effects 57326 Pathology of the Urachus 59527 Pathology of Renal Pelvis, Ureter, and Urethra 61128 Diagnostic Immunohistochemistry 64929 Tissue- Based Biomarkers for Prognosis and to Guide Therapy for Bladder Cancer 67930 Molecular Pathology of Bladder Cancer 71731 Molecular Determinants for Tumor Prognosis and Targeted Therapy 76132 Urine- Based Biomarkers 78733 Evaluation of Hematuria and Urinalysis 81934 Urinary Cytology 829Index 857