The most celebrated era in modern Spider-history continues, featuring a rotating who’s-who of top comic book talents!

Learn how Harry Osborn came back from the dead — and who’s been terrorizing people as Menace! Discover how an adventure from the past will have a profound effect on the future of Spider-Man and the Fantastic Four! And cower in fear as a new Vulture makes his highflying debut! But that’s all nothing compared to Norman Osborn ushering in his Dark Reign — and policing the nation with his Dark Avengers, one of whom is Venom! Peter Parker doesn’t like that one bit. But whose side is the armored American Son on? And what will it mean for Mister Negative? Spidey will go from one of his greatest enemies to another when Doctor Octopus makes a fateful comeback — like never before! Plus: Mary Jane returns! Jackpot goes solo! And Peter crosses the Black Cat’s path once more!

COLLECTING: Amazing Spider-Man (1999) 584-611; Amazing Spider-Man Annual (2009) 36; Amazing Spider-Man: Extra! (2008) 1 (C story), 3; Spider-Man: The Short Halloween One-Shot (2009); Spider-Man: A Chemical Romance Digital Comic (2009) 1; Spider-Man: The Root of All Annoyance Digital Comic (2009) 1; Dark Reign: Mr. Negative (2009) 1-3; Amazing Spider-Man Presents: Anti-Venom - New Ways to Live (2009) 1-3; Amazing Spider-Man Presents: Jackpot (2010) 1-3; Amazing Spider-Man Family (2008) 6-7 (A stories); Web of Spider-Man (2009) 1 (A story)