When trouble occurs in the hard luck Texas town of Sorrowful, young Wylie Fairchild is compelled to take up arms and begin chase of a murderous villain who flees across the Panhandle and takes refuge in the rugged Palo Duro Canyon. Chase the Devil is an old-time, rip-roaring western with cattle drives, good men and a scarred woman, murderous villains and a naive young Wylie who takes it upon himself to even the score.