Hematologist/oncologists rely heavily upon the discipline of hematopathology for the care and management of their patients. Whether interpreting a lymph node or bone marrow biopsy, directing a high throughput automated hematology laboratory, or translating testing modalities from the research bench to the clinical laboratory, hematopathologists and other laboratory medicine specialists provide a steady stream of critical data for the clinical practitioner. Recently the rapid advances in diagnosis and treatment of hematological disorders including the need to evaluate patients' eligibility for and monitor responses to rapidly evolving targeted therapies have made the close collaboration between pathologists and clinician practitioners even more essential. Our goal is to provide outstanding reviews of selected topics in hematopathology in a format that provides both general and historical background, as well as an overview of the state-of-the-art in diagnostic hematopathology, with an eye on future potential and future developments.