A Barry Kay, National Heart and Lung Institute, London, UK Allan P Kaplan, National Allergy and Asthma Centre, South Carolina, USA Jean Bousquet, Hopital Arnaud dde Villeneuve, Montpellier, France Patrick G Holt, Telethon Institute for Child Health, Perth, Australia

"All allergists will benefit from owning this reference. It is an excellent source for learning or brushing up on the most recent knowledge for understanding what causes allergic diseases." (Doody's, 8 April 2011)

• List of Contributors ixForeword xviiPreface xviiiVOLUME 1 The Scientific Basis of AllergyPart 1 Immunology of the Allergic Response1 Allergy and Hypersensitivity: History and Concepts 3A. Barry Kay2 Development of Allergy and Atopy 23Catherine Thornton and Patrick G. Holt3 T Cells and Cytokines in Asthma and Allergic Inflammation 48Chris Corrigan4 Regulatory T Cells and Other Tolerogenic Mechanisms in Allergy and Asthma 83Catherine Hawrylowicz and Cezmi A. Akdis5 IgE and IgE Receptors 103Brian J. Sutton, Andrew J. Beavil, Rebecca L. Beavil, and James Hunt6 Immunoglobulin Gene Organization and Expression and Regulation of IgE 119Hannah J. Gould and David J. Fear7 Environmental Factors in IgE Production 141Anne Tsicopoulos, Catherine Duez, and Andrew Saxon8 Antigen-presenting Dendritic Cells and Macrophages 166Bart N. Lambrecht and Hamida Hammad9 Innate Immunity in Allergic Disease 187Ian Sabroe10 Signal Transduction in Allergic and Inflammatory Cells 203Rafeul AlamPart 2 Inflammatory Cells and Mediators11 Mast Cells: Biological Properties and Role in Health and Allergic Diseases 217Peter Bradding and Glenn Cruse12 Eosinophils: Biological Properties and Role in Health and Disease 258Simon P. Hogan, Helene F. Rosenberg, Redwan Moqbel, Simon Phipps, Paul S. Foster, Paige Lacy, A. Barry Kay, and Marc E. Rothenberg13 Neutrophils: Biological Properties and Role in Health and Allergic Diseases 295Alison M. Condliffe, Andrew S. Cowburn, and Edwin R. Chilvers14 Basophils: Biological Properties and Role in Allergic Diseases 320Gianni Marone, Giuseppe Spadaro, and Arturo Genovese15 Leukocyte Adhesion in Allergic Inflammation 337Michelle J. Muessel and Andrew J. Wardlaw16 Airway Epithelium 366Pedro C. Avila and Robert P. Schleimer17 Airway Vascularity in Asthma 398John W. Wilson18 Fibroblasts and the Extracellular Matrix 412Lynne A. Murray, William G. Glass, Anuk M. Das, and Geoffrey J. Laurent19 Immune Complexes and Complement: Their Role in Host Defense and in Disease 436Michael M. Frank and C. Garren Hester20 Bradykinin Pathways and Allergic Disease 451Allen P. Kaplan21 Chemokines 471James E. Pease and Timothy J. Williams22 Neurotrophins 494Wolfgang A. Nockher, Sanchaita Sonar, and Harald Renz23 Neuropeptides 511David A. Groneberg and Axel Fischer24 Late-phase Allergic Reactions in Humans 524Yee-Ean Ong and A. Barry KayPart 3 Pharmacology25 Antihistamines 551F. Estelle, R. Simons, and Keith J. Simons26 Lipid Mediators: Leukotrienes Prostanoids Lipoxins and Platelet-activating Factor 566Sophie P. Farooque, Jonathan P. Arm, and Tak H. Lee27 Theophylline and Isoenzyme-selective Phosphodiesterase Inhibitors 634Mark A. Giembycz28 Adrenergic Agonists and Antagonists 668Tony R. Bai29 Cholinergic Antagonists 683Nicholas J. Gross30 Antileukotriene Agents 694Graeme P. Currie and Brian J. Lipworth31 Glucocorticosteroids 715Peter J. Barnes32 Immunomodulating Drugs 732Iain A.M. MacPheePart 4 Physiology33 Physiologic Aspects of Asthma 749Philip W. Ind and Neil B. Pride34 Aerosol Delivery Systems 768Thomas G. O’Riordan and Gerald C. Smaldone35 Bronchial Hyperresponsiveness 783Guy F. Joos36 Exercise-induced Bronchoconstriction: Animal Models 794Arthur N. Freed and Sandra D. Anderson37 Exercise-induced Bronchoconstriction: Human Models 808Arthur N. Freed and Sandra D. Anderson38 Sensory and Autonomic Nervous System in Asthma and Rhinitis 823Bradley J. Undem and Kevin Kwong39 Mucus and Mucociliary Clearance in Asthma and Allergic Rhinitis 840Duncan F. Rogers40 Biology of Vascular Permeability 857Peter Clark41 Airway Smooth Muscle 874Stuart J. HirstPart 5 Allergens42 Biochemistry of Allergens and Recombinant Allergens 895Rudolf Valenta43 Host Responses to Allergens 913Wayne R. Thomas and Belinda J. Hales44 Allergen Extracts and Standardization 928Ronald van Ree45 Grass Tree and Weed Pollen 942Jean Emberlin46 Fungi as Allergens 963Cathryn C. Hassett, W. Elliott Horner, Estelle Levetin, Laurianne G. Wild, W. Edward Davis, Samuel B. Lehrer, and John Lacey47 Dust Mites and Asthma 984Thomas A.E. Platts-Mills and Judith A. Woodfolk48 Animal Allergens 997Adnan Custovic and Angela Simpson49 Airborne Allergens and Irritants in the Workplace 1017Xaver Baur50 Allergens from Stinging Insects: Ants Bees and Vespids 1123Te Piao King and Rafael I. Monsalve51 Cockroach Allergens Environmental Exposure and Asthma 1131Martin D. Chapman and Anna Pomés52 Food Allergens 1146Ricki M. Helm and A. Wesley Burks53 Latex Allergy 1164Robyn E. O’Hehir, Michael F. Sutherland, Alexander C. Drew, and Jennifer M. RollandPart 6 Animal Models of Asthma54 Primate Models of Allergic Asthma 1187Charles G. Plopper, Suzette M. Smiley-Jewell, Lisa A. Miller, Michelle V. Fanucchi, Michael J. Evans, Alan R. Buckpitt, Mark V. Avdalovic, Laurel J. Gershwin, Jesse P. Joad, Radhika Kajekar, Shawnessy D. Larson, Kent E. Pinkerton, Laura S. Van Winkle, Edward S. Schelegle, Emily M. Pieczarka, Reen Wu, and Dallas M. Hyde55 Airway Remodeling in Small Animal Models 1202Clare M. Lloyd56 Are Animal Models of Asthma Useful? 1214Reinhard PabstIndexVOLUME 2 Allergic Diseases: Etiology Diagnosis and TreatmentPart 7 Etiology and Pathology57 Genetics of Asthma and Atopic Dermatitis 1225Saffron A.G. Willis-Owen, Miriam F. Moffatt, and William O.C. Cookson58 Epidemiology of Asthma Atopy and Atopic Disease 1239Debbie L. Jarvis, Seif O. Shaheen, and Peter Burney59 The Allergy March 1259Ulrich Wahn60 Outdoor Air Pollution and Allergic Airway Disease 1266Gennaro D’Amato61 Indoor Air Pollution 1279Paul Harrison, Rebecca Slack, and Sanjeev Bagga62 Molecular Immunopathology of Allergic Disease 1290Susan Foley and Qutayba HamidPart 8 Diagnosis of Allergic Disease63 Principles and Practice of Diagnosis and Treatment of Allergic Disease 1321Anthony J. Frew and A. Barry Kay64 Skin Testing in Diagnosis and Management of Respiratory Allergic Diseases 1335Pascal Demoly, Anaïs Pipet, and Jean Bousquet65 Allergy Testing in the Laboratory 1346Steven O. Stapel and Jörg Kleine-Tebbe66 Measurement of Markers of Inflammation in Induced Sputum and Exhaled Air 1368Ian D. Pavord and Dominick E. ShawPart 9 Allergic Rhinoconjunctivitis and Immunotherapy67 Definition and Classification of Allergic Rhinitis and Upper Airways Diseases 1383Wytske Fokkens and Jean Bousquet68 Pathophysiology of Allergic Rhinitis 1402Peter H. Howarth69 Management and Treatment of Allergic Rhinitis 1430Jean Bousquet and Michael A. Kaliner70 Nasal Polyps and Rhinosinusitis 1454Wouter Huvenne, Paul Van Cauwenberge, and Claus Bachert71 Ocular Allergy 1482Avinash Gurbaxani, Virginia L. Calder, and Susan Lightman72 Mechanisms in Allergen Injection Immunotherapy 1510Stephen J. Till and Stephen R. Durham73 Allergen Injection Immunotherapy: Indications and Practice 1522Hans-Jørgen Malling74 Sublingual Immunotherapy 1543G. Walter Canonica and Giovanni Passalacqua75 Novel Approaches to Allergen Immunotherapy 1555Mark LarchéPart 10 Asthma and its Treatment76 Definition Clinical Features Investigations and Differential Diagnosis of Asthma 1567Piero Maestrelli, Gaetano Caramori, Francesca Franco, and Leonardo M. Fabbri77 Asthma in Infancy and Childhood 1591John O. Warner78 Pathogenesis of Asthma 1608Stephen T. Holgate79 Pathology of Asthma 1632Peter K. Jeffery, A. Barry Kay, and Qutayba Hamid80 Management of Chronic Asthma 1650Peter J. Barnes81 Anti-IgE in Persistent Severe Allergic Asthma 1661Marc Humbert, Stephen T. Holgate, Howard Fox, and Jean Bousquet82 Occupational Asthma 1687Paul Cullinan and Anthony J. Newman Taylor83 New Drugs for the Treatment of Allergy and Asthma 1712Trevor T. Hansel, Ed Erin Onn, Min Kon, and Peter J. BarnesPart 11 Eosinophil-associated Disease and Hypersensitivity Pneumonitis84 Allergic Bronchopulmonary Aspergillosis 1743André-Bernard Tonnel, Stéphanie, Pouwels-Frys, and Isabelle Tillie-Leblond85 Extrinsic Allergic Alveolitis/Hypersensitivity Pneumonitis 1757Michael C. Zacharisen and Jordan N. Fink86 Pulmonary Eosinophilia 1779Jean-François Cordier and Vincent Cottin87 Hypereosinophilic Syndromes 1802Hans-Uwe SimonPart 12 Allergy and the Skin88 Atopic Dermatitis 1813Julia D. Proelss and Thomas Bieber89 Contact Dermatitis 1831David I. Orton and Carolyn M. Willis90 Urticaria and Angioedema 1853Allen P. Kaplan91 Mastocytosis 1878Nataliya M. Kushnir-Sukhov, Dean D. Metcalfe, and Jamie A. RobynPart 13 Anaphylaxis and Allergy to Food and Drugs92 Anaphylaxis 1897M. Rosario Caballero, Stephen J. Lane, and Tak H. Lee93 Food Allergy and Eosinophilic Gastroenteropathies 1921Scott H. Sicherer and Hugh A. Sampson94 Drug Hypersensitivity 1943Werner J. Pichler95 Hypersensitivity to Aspirin and other NSAIDs 1966Andrzej Szczeklik, Ewa NiLankowska-Mogilnicka, and Marek Sanak96 Insect Sting Allergy 1980Ulrich R. MüllerPart 14 Prevention of Allergic Disease97 Prevention of Allergic Disease 1997Susan L. Prescott and Bengt Björkstén98 Prevalence of Atopic Disorders in a Developing World: Pitfalls and Opportunities 2020Maria Yazdanbakhsh, Taniawati Supali, and Laura C. RodriguesIndex