Malcolm Macleod, Reader and Head of Experimental Neuroscience, Centre for Clinical Brain Sciences, University of Edinburgh, and Honorary Consultant Neurologist and Clinical Lead for Neurology, NHS Forth Valley, Stirling Marion Simpson, Neurology Registrar, The Austin Hospital, Melbourne, Australia Suvankar Pal, Neurology Registrar, Western General Hospital, Edinburgh

• Preface viiAcknowledgements viiiHow to Use This Book ixList of Abbreviations xPart 1 Basics 1Basic science 1Approach to the patient 10Part 2 Cases 18Case 1 A 76-year-old man whose hand went weak 18Case 2 A 60-year-old man with back pain and weakness 22Case 3 A 25-year-old woman with weakness and tingling in her arms and legs 27Case 4 A 45-year-old man with uncontrollable seizures 32Case 5 A 24-year-old woman with headaches and abnormal optic fundi 36Case 6 A 37-year-old man with sudden severe headache 39Case 7 A 17-year-old girl who becomes unresponsive after a late night 46Case 8 A 30-year-old woman found fitting on the train 51Case 9 A 66-year-old woman with confusion and weakness 54Case 10 An 18-year-old girl with headache fever and confusion 58Case 11 A 30-year-old woman with double vision and fatigue 61Case 12 A 29-year-old woman with tingling weakness of the left arm and leg 67Case 13 A 45-year-old woman with pain in the leg 70Case 14 A 29-year-old woman thrown from her horse 73Case 15 A 67-year-old man who is unsteady on his feet 77Case 16 A 49-year old man with burning in the feet and difficulty walking 81Case 17 A 72-year-old woman with memory problems 86Case 18 A 54-year-old woman with tingling hands 90Case 19 A 26-year-old woman with right-sided weakness 93Case 20 A 19-year-old woman with acute headache and tingling 97Case 21 A 63-year-old man whose hands have got so weak he can’t work 101Case 22 A 55-year-old woman with episodes of excruciating facial pain 105Case 23 A 38-year-old man with heaviness of the legs 108Case 24 An 84-year-old man with confusion and unsteadiness 112Case 25 A 45-year-old man with constant headache 115Case 26 A 68-year-old man with a 2-week history of unsteadiness 118Case 27 A 15-year-old girl with fidgeting movements 121Part 3 Self-assessment 124MCQs 124EMQs 131SAQs 135Answers 140Index of cases by diagnosis 146Index 147