Daniel R. Weinberger, Director: Genes, Cognition and Psychosis Program, National Institute of Mental  Health, National Institute of Health, Bethesda, USA Paul J. Harrison, University Department of Psychiatry, Warneford Hospital, Oxford, UK

"I thoroughly recommend this book as a well-integrated collection of thoughtful and up-to-date expositions on every aspect of schizophrenia, by some of the best scientists in the field. " (Psychological Medicine, 2012) “It will be of valuable to practising psychiatrists and to trainees, as well as to the clinical and neuroscience researchers interested in keeping up with this field or coming into it.”  (Buchtipps,  September 2012)"The contributing authors and editors constitute an international list of '"who's who" in contemporary schizophrenia research. Overall this book represents a highly systematic, comprehensive, scholarly, and critical appraisal of a core component of modern psychiatry and a major publice health challenge. It ably summarizes and evalutates efforts to better understand the nature, diagnosis, biology, psychology, sociology and clinical treatment of the group of largely "nonaffective" psychotic disorders currently considered within the nosological domain of schizophrenia. As such, it is an essential volume for students, researchers, clinicians, and administrators interested in improved understanding and care of persons diagnosed with psychotic disorders." (Journal of Clinical Psychiatry, 2012)

• Contributors viiEditor's Note xiPreface to the 3 Rd Edition xiiPreface to the First Edition xiiiPart 1 Descriptive Aspects 11 Concept of schizophrenia: past present and future 3Nancy C. Andreasen2 The schizophrenia construct: symptomatic presentation 9Celso Arango and William T. Carpenter3 Child and adolescent schizophrenia 24Chris Hollis and Judith Rapoport4 Late-onset schizophrenia 47Robert Howard and Dilip Jeste5 The schizophrenia spectrum personality disorders 62Eran Chemerinski and Larry J. Siever6 The prodrome of schizophrenia 91Jean Addington and Shôn W. Lewis7 Course and outcome 104Wolfram an der Heiden and Heinz Häfner8 Neurocognitive impairments in schizophrenia: their character and role in symptom formation 142Terry E. Goldberg Anthony David and James. M. GoldPart 2 Biological Aspects 1639 The secondary schizophrenias 165Thomas M. Hyde and Maria A. Ron10 Schizophrenia: the epidemiological horizon 185Assen Jablensky James B. Kirkbride and Peter B. Jones11 Environmental risk factors for schizophrenia 226John J. McGrath and Robin M. Murray12 Classical genetic studies of schizophrenia 245Brien Riley and Kenneth S. Kendler13 Genetic associations in schizophrenia 269Michael C. O'Donovan and Michael J. Owen14 Intermediate phenotypes in genetic studies of schizophrenia 289Michael F. Egan and Tyrone D. Cannon15 Electrophysiology of schizophrenia 311Georg Winterer and Robert W. McCarley16 Structural brain imaging in schizophrenia and related populations 334Stephen M. Lawrie and Christos Pantelis17 Functional brain imaging in schizophrenia 353Andreas Meyer-Lindenberg and Edward T. Bullmore18 Neuropathology of schizophrenia 372Paul J. Harrison David A. Lewis and Joel E. Kleinman19 Neurodevelopmental origins of schizophrenia 393Daniel R. Weinberger and Pat Levitt20 Dopamine and schizophrenia 413Anissa Abi-Dargham and Anthony A. Grace21 Contributions of glutamate and GABA systems to the neurobiology and treatment of schizophrenia 433John H. Krystal and Bita Moghaddam22 Animal models of schizophrenia 462Barbara K. Lipska and Joseph A. GogosPart 3 Physical Treatments 48323 Pharmacology and neuroscience of antipsychotic drugs 485John L. Waddington Colm M.P. O'Tuathaigh and Gary J. Remington24 Principles of pharmacological treatment in schizophrenia 515Thomas R.E. Barnes and Stephen R. Marder25 Comparative efficacy and effectiveness in the drug treatment of schizophrenia 525John R. Geddes T. Scott Stroup and Jeffrey A. Lieberman26 Approaches to treatment-resistant patients 540Stephan Leucht Christoph U. Correll and John M. Kane27 Neurological complications of antipsychotic drugs 561Peter M. Haddad and Venkata S. Mattay28 Metabolic adverse effects associated with antipsychotic medications 577John W. Newcomer and Stefan LeuchtPart 4 Psychosocial Aspects 59929 Schizophrenia and psychosocial stresses 601Paul E. Bebbington and Elizabeth Kuipers30 Mental health services for patients with schizophrenia 625Tom Burns and Bob Drake31 Societal outcomes in schizophrenia 644Iain Kooyman and Elizabeth Walsh32 Psychological treatment of psychosis 666Gillian Haddock and Will Spaulding33 Economics of the treatment of schizophrenia 687Nancy H. Covell Susan M. Essock and Linda K. FrismanIndex 701Colour plates are found facing page 338

Daniel R. Weinberger, Director: Genes, Cognition and Psychosis Program, National Institute of Mental  Health, National Institute of Health, Bethesda, USA Paul J. Harrison, University Department of Psychiatry, Warneford Hospital, Oxford, UK

"I thoroughly recommend this book as a well-integrated collection of thoughtful and up-to-date expositions on every aspect of schizophrenia, by some of the best scientists in the field. " (Psychological Medicine, 2012) “It will be of valuable to practising psychiatrists and to trainees, as well as to the clinical and neuroscience researchers interested in keeping up with this field or coming into it.”  (Buchtipps,  September 2012)"The contributing authors and editors constitute an international list of '"who's who" in contemporary schizophrenia research. Overall this book represents a highly systematic, comprehensive, scholarly, and critical appraisal of a core component of modern psychiatry and a major publice health challenge. It ably summarizes and evalutates efforts to better understand the nature, diagnosis, biology, psychology, sociology and clinical treatment of the group of largely "nonaffective" psychotic disorders currently considered within the nosological domain of schizophrenia. As such, it is an essential volume for students, researchers, clinicians, and administrators interested in improved understanding and care of persons diagnosed with psychotic disorders." (Journal of Clinical Psychiatry, 2012)

• Contributors viiEditor's Note xiPreface to the 3 Rd Edition xiiPreface to the First Edition xiiiPart 1 Descriptive Aspects 11 Concept of schizophrenia: past present and future 3Nancy C. Andreasen2 The schizophrenia construct: symptomatic presentation 9Celso Arango and William T. Carpenter3 Child and adolescent schizophrenia 24Chris Hollis and Judith Rapoport4 Late-onset schizophrenia 47Robert Howard and Dilip Jeste5 The schizophrenia spectrum personality disorders 62Eran Chemerinski and Larry J. Siever6 The prodrome of schizophrenia 91Jean Addington and Shôn W. Lewis7 Course and outcome 104Wolfram an der Heiden and Heinz Häfner8 Neurocognitive impairments in schizophrenia: their character and role in symptom formation 142Terry E. Goldberg Anthony David and James. M. GoldPart 2 Biological Aspects 1639 The secondary schizophrenias 165Thomas M. Hyde and Maria A. Ron10 Schizophrenia: the epidemiological horizon 185Assen Jablensky James B. Kirkbride and Peter B. Jones11 Environmental risk factors for schizophrenia 226John J. McGrath and Robin M. Murray12 Classical genetic studies of schizophrenia 245Brien Riley and Kenneth S. Kendler13 Genetic associations in schizophrenia 269Michael C. O'Donovan and Michael J. Owen14 Intermediate phenotypes in genetic studies of schizophrenia 289Michael F. Egan and Tyrone D. Cannon15 Electrophysiology of schizophrenia 311Georg Winterer and Robert W. McCarley16 Structural brain imaging in schizophrenia and related populations 334Stephen M. Lawrie and Christos Pantelis17 Functional brain imaging in schizophrenia 353Andreas Meyer-Lindenberg and Edward T. Bullmore18 Neuropathology of schizophrenia 372Paul J. Harrison David A. Lewis and Joel E. Kleinman19 Neurodevelopmental origins of schizophrenia 393Daniel R. Weinberger and Pat Levitt20 Dopamine and schizophrenia 413Anissa Abi-Dargham and Anthony A. Grace21 Contributions of glutamate and GABA systems to the neurobiology and treatment of schizophrenia 433John H. Krystal and Bita Moghaddam22 Animal models of schizophrenia 462Barbara K. Lipska and Joseph A. GogosPart 3 Physical Treatments 48323 Pharmacology and neuroscience of antipsychotic drugs 485John L. Waddington Colm M.P. O'Tuathaigh and Gary J. Remington24 Principles of pharmacological treatment in schizophrenia 515Thomas R.E. Barnes and Stephen R. Marder25 Comparative efficacy and effectiveness in the drug treatment of schizophrenia 525John R. Geddes T. Scott Stroup and Jeffrey A. Lieberman26 Approaches to treatment-resistant patients 540Stephan Leucht Christoph U. Correll and John M. Kane27 Neurological complications of antipsychotic drugs 561Peter M. Haddad and Venkata S. Mattay28 Metabolic adverse effects associated with antipsychotic medications 577John W. Newcomer and Stefan LeuchtPart 4 Psychosocial Aspects 59929 Schizophrenia and psychosocial stresses 601Paul E. Bebbington and Elizabeth Kuipers30 Mental health services for patients with schizophrenia 625Tom Burns and Bob Drake31 Societal outcomes in schizophrenia 644Iain Kooyman and Elizabeth Walsh32 Psychological treatment of psychosis 666Gillian Haddock and Will Spaulding33 Economics of the treatment of schizophrenia 687Nancy H. Covell Susan M. Essock and Linda K. FrismanIndex 701Colour plates are found facing page 338

Daniel R. Weinberger, Director: Genes, Cognition and Psychosis Program, National Institute of Mental  Health, National Institute of Health, Bethesda, USA Paul J. Harrison, University Department of Psychiatry, Warneford Hospital, Oxford, UK

"I thoroughly recommend this book as a well-integrated collection of thoughtful and up-to-date expositions on every aspect of schizophrenia, by some of the best scientists in the field. " (Psychological Medicine, 2012) “It will be of valuable to practising psychiatrists and to trainees, as well as to the clinical and neuroscience researchers interested in keeping up with this field or coming into it.”  (Buchtipps,  September 2012)"The contributing authors and editors constitute an international list of '"who's who" in contemporary schizophrenia research. Overall this book represents a highly systematic, comprehensive, scholarly, and critical appraisal of a core component of modern psychiatry and a major publice health challenge. It ably summarizes and evalutates efforts to better understand the nature, diagnosis, biology, psychology, sociology and clinical treatment of the group of largely "nonaffective" psychotic disorders currently considered within the nosological domain of schizophrenia. As such, it is an essential volume for students, researchers, clinicians, and administrators interested in improved understanding and care of persons diagnosed with psychotic disorders." (Journal of Clinical Psychiatry, 2012)

• Contributors viiEditor's Note xiPreface to the 3 Rd Edition xiiPreface to the First Edition xiiiPart 1 Descriptive Aspects 11 Concept of schizophrenia: past present and future 3Nancy C. Andreasen2 The schizophrenia construct: symptomatic presentation 9Celso Arango and William T. Carpenter3 Child and adolescent schizophrenia 24Chris Hollis and Judith Rapoport4 Late-onset schizophrenia 47Robert Howard and Dilip Jeste5 The schizophrenia spectrum personality disorders 62Eran Chemerinski and Larry J. Siever6 The prodrome of schizophrenia 91Jean Addington and Shôn W. Lewis7 Course and outcome 104Wolfram an der Heiden and Heinz Häfner8 Neurocognitive impairments in schizophrenia: their character and role in symptom formation 142Terry E. Goldberg Anthony David and James. M. GoldPart 2 Biological Aspects 1639 The secondary schizophrenias 165Thomas M. Hyde and Maria A. Ron10 Schizophrenia: the epidemiological horizon 185Assen Jablensky James B. Kirkbride and Peter B. Jones11 Environmental risk factors for schizophrenia 226John J. McGrath and Robin M. Murray12 Classical genetic studies of schizophrenia 245Brien Riley and Kenneth S. Kendler13 Genetic associations in schizophrenia 269Michael C. O'Donovan and Michael J. Owen14 Intermediate phenotypes in genetic studies of schizophrenia 289Michael F. Egan and Tyrone D. Cannon15 Electrophysiology of schizophrenia 311Georg Winterer and Robert W. McCarley16 Structural brain imaging in schizophrenia and related populations 334Stephen M. Lawrie and Christos Pantelis17 Functional brain imaging in schizophrenia 353Andreas Meyer-Lindenberg and Edward T. Bullmore18 Neuropathology of schizophrenia 372Paul J. Harrison David A. Lewis and Joel E. Kleinman19 Neurodevelopmental origins of schizophrenia 393Daniel R. Weinberger and Pat Levitt20 Dopamine and schizophrenia 413Anissa Abi-Dargham and Anthony A. Grace21 Contributions of glutamate and GABA systems to the neurobiology and treatment of schizophrenia 433John H. Krystal and Bita Moghaddam22 Animal models of schizophrenia 462Barbara K. Lipska and Joseph A. GogosPart 3 Physical Treatments 48323 Pharmacology and neuroscience of antipsychotic drugs 485John L. Waddington Colm M.P. O'Tuathaigh and Gary J. Remington24 Principles of pharmacological treatment in schizophrenia 515Thomas R.E. Barnes and Stephen R. Marder25 Comparative efficacy and effectiveness in the drug treatment of schizophrenia 525John R. Geddes T. Scott Stroup and Jeffrey A. Lieberman26 Approaches to treatment-resistant patients 540Stephan Leucht Christoph U. Correll and John M. Kane27 Neurological complications of antipsychotic drugs 561Peter M. Haddad and Venkata S. Mattay28 Metabolic adverse effects associated with antipsychotic medications 577John W. Newcomer and Stefan LeuchtPart 4 Psychosocial Aspects 59929 Schizophrenia and psychosocial stresses 601Paul E. Bebbington and Elizabeth Kuipers30 Mental health services for patients with schizophrenia 625Tom Burns and Bob Drake31 Societal outcomes in schizophrenia 644Iain Kooyman and Elizabeth Walsh32 Psychological treatment of psychosis 666Gillian Haddock and Will Spaulding33 Economics of the treatment of schizophrenia 687Nancy H. Covell Susan M. Essock and Linda K. FrismanIndex 701Colour plates are found facing page 338