Receptor - Based Drug Design

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PDF, Engelska, 1998

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Beskrivning

Employing a wide range of examples from G-protein-coupled receptors and ligand-gated ion channels, this detailed, single-source reference illustrates the principles of pharmacological analysis and receptor classification that are the basis of rational drug design.Explains the experimental and theoretical methods used to characterize interactio

Produktinformation

Utgivningsdatum:1998-04-10
Språk:Engelska
Filformat:PDF
Kopieringsskydd:LCP
ISBN:9781420001136
Förlag:Taylor & Francis Inc

Utforska kategorier

Farmakologi inom Medicin
Kemi inom Naturvetenskap och teknik
Fysikalisk kemi inom Naturvetenskap och teknik

Innehållsförteckning

Introduction, James BlackPrinciples and Measurement of Drug-Receptor InteractionsThe Characterization and Classification of Receptors, Patrick P. A. HumphreyFunctional Methods for Quantifying Agonists and Antagonists, Iain G. DougallQuantification of Receptor Interactions Using Binding Methods, Sebastian LazarenoDrug Analysis Based on Signaling Responses to G-Protein-Coupled Receptors, T. Kendall Harden, Jose L. Boyer, and Robert W. DoughertyThe Use of Electrophysiology to Improve Understanding of Drug-Receptor Interactions, John G. Connolly and Charles KennedyReceptor-Based Drugs in MedicineSelective Adrenergic and Glucocorticoid Treatments for Asthma, David JackSerotonin 5-HT1B/D Receptor Agonists, Graeme R. MartinHistamine H2-Receptor Antagonists, Michael E. ParsonsAngiotensin Antagonists, Mark J. RobertsonExperimental and Emerging Drugs-Adrenoceptor Agonists and Antagonists, J. Paul Hieble and Robert R. Ruffolo, Jr.P2U-Purinoceptor Agonists: Emerging Therapy for Pulmonary Diseases, Eduardo R. Lazarowski, William C. Watt, T. Kendall Harden, and Richard C. BoucherMuscarinic Receptor Antagonists Pharmacological and Therapeutic Utility, Richard M. EglenNMDA Receptor Antagonists, John A. Kemp and James N. C. KewNew Trends in Drug DesignComputational Chemistry in Receptor-Based Drug Design, Ad P. IJzerman, Eleonora M. van der Wenden, and Wilma KuipersRecombinant G-Protein-Coupled Receptors as Screening Tools for Drug Discovery, A. Donny Strosberg and Prabhavathi B. FernandesInverse Agonists and G-Protein-Coupled Receptors, Richard A. Bond and Michel Bouvier