Läs direkt i Bokus Reader – eller ladda ned till din enhet (PDF kräver ofta zoom och scroll på små skärmar).
Beskrivning
Employing a wide range of examples from G-protein-coupled receptors and ligand-gated ion channels, this detailed, single-source reference illustrates the principles of pharmacological analysis and receptor classification that are the basis of rational drug design.Explains the experimental and theoretical methods used to characterize interactio
Introduction, James BlackPrinciples and Measurement of Drug-Receptor InteractionsThe Characterization and Classification of Receptors, Patrick P. A. HumphreyFunctional Methods for Quantifying Agonists and Antagonists, Iain G. DougallQuantification of Receptor Interactions Using Binding Methods, Sebastian LazarenoDrug Analysis Based on Signaling Responses to G-Protein-Coupled Receptors, T. Kendall Harden, Jose L. Boyer, and Robert W. DoughertyThe Use of Electrophysiology to Improve Understanding of Drug-Receptor Interactions, John G. Connolly and Charles KennedyReceptor-Based Drugs in MedicineSelective Adrenergic and Glucocorticoid Treatments for Asthma, David JackSerotonin 5-HT1B/D Receptor Agonists, Graeme R. MartinHistamine H2-Receptor Antagonists, Michael E. ParsonsAngiotensin Antagonists, Mark J. RobertsonExperimental and Emerging Drugs-Adrenoceptor Agonists and Antagonists, J. Paul Hieble and Robert R. Ruffolo, Jr.P2U-Purinoceptor Agonists: Emerging Therapy for Pulmonary Diseases, Eduardo R. Lazarowski, William C. Watt, T. Kendall Harden, and Richard C. BoucherMuscarinic Receptor Antagonists Pharmacological and Therapeutic Utility, Richard M. EglenNMDA Receptor Antagonists, John A. Kemp and James N. C. KewNew Trends in Drug DesignComputational Chemistry in Receptor-Based Drug Design, Ad P. IJzerman, Eleonora M. van der Wenden, and Wilma KuipersRecombinant G-Protein-Coupled Receptors as Screening Tools for Drug Discovery, A. Donny Strosberg and Prabhavathi B. FernandesInverse Agonists and G-Protein-Coupled Receptors, Richard A. Bond and Michel Bouvier
