In late 2012, the CSIS Global Health Policy Center organized a working group to analyze the opportunities for global health diplomacy in Barack Obama’s second term. This volume presents those analyses. Taken together, the studies show that the world of global health diplomacy is quite dynamic at the moment, with new partners setting trends while traditional actors are reconfiguring their views and practices. As the Obama administration moves into a second term, there are numerous opportunities for U.S. diplomats to coordinate on global health goals with middle income countries such as Brazil, Chile, Mexico, and South Korea; to learn more about how Russia and China continue to build their outreach and assistance capacities; and to strengthen existing relationships with Canada, Japan, and Europe to shore up support and innovation in the global commitment to public health.