Inflammation and Allergy Drug Design

Edited byK. Izuhara, MD, PhD, Saga Medical School, Nabeshima, JapanStephen T. Holgate, MD, DSc, FRCP, Southampton General Hospital, UKMarsha Wills-Karp, PhD, Children’s Hospital Medical Center, Cincinnati, USA

• Contributors, vii Preface, xiiiPart I: Cells contributing to the pathogenesis of allergic diseases in the respiratory tract1 Novel anti-infl ammatory drugs based on targeting lung dendritic cells and airway epithelial cells, 3Bart N. Lambrecht, Maud Plantinga, Monique Willart, and Hamida Hammad2 Role of Th2 cells in the allergic diathesis, 15Marsha Wills-Karp3 Importance of Th17- and Th1-associated responses for the development of asthma, 27Tomohiro Yoshimoto, Hiroko Tsutsui, and Kenji Nakanishi4 Regulatory T cells, 39Chris Corrigan and Kimuli Ryanna5 A role for natural killer T-cell subsets in the pathogenesis of various allergic disorders, 59Hiroshi Watarai, Michishige Harada, Mayumi Tamari, and Masaru Taniguchi6 Regulatory roles of B cells in allergy and infl ammation, 67Kiyoshi Takatsu, Masashi Ikutani and Yoshinori Nagai7 Mast cells, 79Mindy Tsai and Stephen J. Galli8 Eosinophils, 107Nancy A. Lee, Mark V. Dahl, Elizabeth A. Jacobsen, and Sergei I. Ochkur9 Basophils in infl ammation and allergy drug design, 123Donald MacGlashan, Jr.10 Epithelial cells, 139Tillie-Louise Hackett, Stephanie Warner, Dorota Stefanowicz, and Darryl Knight11 Fibroblasts, 149Alastair G. Stewart, Lilian Soon, and Michael Schuliga12 Airway smooth muscle cells, 163Andrew J. Halayko and Pawan SharmaPart II: Cytokines contributing to the pathogenesis of allergic diseases in the respiratory tract13 Interleukin 4, interleukin 13, and interleukin 9, 175Kenji Izuhara, Shoichiro Ohta, Hiroshi Shiraishi, and Shoichi Suzuki14 Interleukin 3, interleukin 5, and granulocyte–macrophage colony-stimulating factor, 187Alba Llop-Guevara, Josip Marcinko, Ramzi Fattouh, and Manel Jordana15 Interleukin 15, interleukin 17, and interleukin 25, 197Hiroshi Nakajima and Itsuo Iwamoto16 Thymic stromal lymphopoietin, 205Kazuhiko Arima and Yong-Jun Liu17 Interleukin 10, 215Whitney W. Stevens, Larry Borish, and John W. Steinke18 Tumor necrosis factor alpha, 225Christopher Brightling, Latifa Chachi, Dhan Desai, and Yassine Amrani19 Profi brotic and angiogenic factors in asthma, 237Neville Berkman and Francesca Levi-Schaffer20 Chemokines, 253Luis M. Teran and Juan R. Velazquez21 Epithelial growth factors, 263Yasuhiro Gon and Shu HashimotoPart III: Other mediators contributing to the pathogenesis of allergic diseases in the respiratory tract22 Prostanoids, 273Sarah A. Maher, Deborah L. Clarke, and Maria G. Belvisi23 Leukotrienes, 285Katsuhide Okunishi and Marc Peters-Golden24 Proteases in allergy, 297Keisuke Oboki and Hirohisa Saito25 Toll-like receptors, 307Jessica L. Allen, Aurelien Trompette, and Christopher L. KarpIndex, 317