Peter Thomson is Professor of Oral and Maxillofacial Surgery at Newcastle University and Honorary Consultant in Oral and Maxillofacial Surgery at Newcastle upon Tyne Hospitals NHS Foundation Trust. In recognition of his research into oral cancer & precancer, he has been awarded both a Hunterian Professorship from the Royal College of Surgeons of England & a King James IV Professorship from the Royal College of Surgeons in Edinburgh.

“I would highly recommend the book for those wishing to expand their knowledge on oral malignancy at a specialist trainee or higher level.”  (British Dental Journal, 12 October 2013)

• List of Contributors PrefaceAcknowledgements1. IntroductionGeneral IntroductionEpidemiologyPrevention Treatment StrategiesTerminologySummaryReferences2. Structure and Function of Oral MucosaIntroductionApplied Anatomy of the Oral CavityFunction of the Oral MucosaThe Microanatomy of Oral MucosaRegional Variation of Oral MucosaOral Epithelial Cell KineticsOral Epithelial Cell Proliferative ActivityAnatomical Site Predilection for Oral CarcinogenesisSummaryReferences3. Oral CarcinogenesisIntroductionOral Cancer and PrecancerThe ‘Progression Model’ for Oral CancerAetiology and Risk FactorsPatient and Risk Factor ProfilingSummaryReferences4. Clinical Presentation of Oral PrecancerIntroductionClinical TerminologyPrecancerous (Premalignant) LesionsPrecancerous (Premalignant) ConditionsMultiple Lesion DiseaseSummaryReferences5. Diagnostic MethodsIntroductionScreeningClinical Examination TechniquesVital Tissue StainingLight Based Detection SystemsBrush Biopsy and Exfoliative CytologyClinical Diagnosis in PracticeSummaryReferences6. Pathological Aspects of Oral PrecancerIntroductionBiopsy TechniquesThe Role of the PathologistHistopathological Features of Oral Potentially Malignant DisordersGrading of DysplasiaLimitations in Conventional Pathological TechniquesSummaryReferences7. Management of Oral PrecancerIntroductionRisk Factor ModificationObservation versus InterventionMedical TreatmentSurgical TreatmentInterventional Laser SurgeryCombined Treatment ModalitiesPatient Follow Up and SurveillanceSummaryReferences8. Clinical OutcomeIntroductionClinical Outcome StudiesPatient Cohort StudiesDefinitions of Clinical OutcomeNewcastle Patient Cohort StudiesPatient Follow UpPrediction of Clinical OutcomeSummaryReferences9. Malignant Transformation and Oral Cancer DevelopmentIntroductionThe Risk of Progression to Oral CarcinomaMalignant Transformation versus Oral Cancer DevelopmentInterventional Laser Surgery and Oral Cancer PreventionThe Newcastle 10 Year Follow Up StudyHigh and Low Risk PatientsClinical Signs of Oral Squamous Cell CarcinomaDiagnosis and Management of ‘Unexpected Malignancy’Prognosis for the ‘Transformed Patient’SummaryReferences10. The FutureIntroductionPrevention of Oral PrecancerEarly Diagnosis of Potentially Malignant DiseaseInterventional Management Strategies in the FutureIndividualised Patient Treatments – Biomarkers and Targeted ChemopreventionFuture Research DirectionsSummaryReferences11. Case HistoriesIntroductionDiagnosis of Unexpected MalignancyMultiple Lesion Disease Responding to Conservative ManagementMultiple Lesion Disease Requiring Repeated Laser TreatmentsProliferative Verrucous LeukoplakiaLocalised Oral Lichenoid ReactionMultiple Oral Lichenoid ReactionsWidespread Dysplastic Oral Lichenoid ReactionsAn Immunosuppressed PatientChronic Hyperplastic CandidosisTobacco Associated HyperkeratosisMalignant Transformation in Longstanding Non-erosive Lichen PlanusSummary12. ConclusionsOral Cancer Potentially Malignant DisordersClinical ManagementPatient Care PathwaysPublic Health StrategiesFuture DirectionsIndex

Peter Thomson is Professor of Oral and Maxillofacial Surgery at Newcastle University and Honorary Consultant in Oral and Maxillofacial Surgery at Newcastle upon Tyne Hospitals NHS Foundation Trust. In recognition of his research into oral cancer & precancer, he has been awarded both a Hunterian Professorship from the Royal College of Surgeons of England & a King James IV Professorship from the Royal College of Surgeons in Edinburgh.

“I would highly recommend the book for those wishing to expand their knowledge on oral malignancy at a specialist trainee or higher level.”  (British Dental Journal, 12 October 2013)

• List of Contributors PrefaceAcknowledgements1. IntroductionGeneral IntroductionEpidemiologyPrevention Treatment StrategiesTerminologySummaryReferences2. Structure and Function of Oral MucosaIntroductionApplied Anatomy of the Oral CavityFunction of the Oral MucosaThe Microanatomy of Oral MucosaRegional Variation of Oral MucosaOral Epithelial Cell KineticsOral Epithelial Cell Proliferative ActivityAnatomical Site Predilection for Oral CarcinogenesisSummaryReferences3. Oral CarcinogenesisIntroductionOral Cancer and PrecancerThe ‘Progression Model’ for Oral CancerAetiology and Risk FactorsPatient and Risk Factor ProfilingSummaryReferences4. Clinical Presentation of Oral PrecancerIntroductionClinical TerminologyPrecancerous (Premalignant) LesionsPrecancerous (Premalignant) ConditionsMultiple Lesion DiseaseSummaryReferences5. Diagnostic MethodsIntroductionScreeningClinical Examination TechniquesVital Tissue StainingLight Based Detection SystemsBrush Biopsy and Exfoliative CytologyClinical Diagnosis in PracticeSummaryReferences6. Pathological Aspects of Oral PrecancerIntroductionBiopsy TechniquesThe Role of the PathologistHistopathological Features of Oral Potentially Malignant DisordersGrading of DysplasiaLimitations in Conventional Pathological TechniquesSummaryReferences7. Management of Oral PrecancerIntroductionRisk Factor ModificationObservation versus InterventionMedical TreatmentSurgical TreatmentInterventional Laser SurgeryCombined Treatment ModalitiesPatient Follow Up and SurveillanceSummaryReferences8. Clinical OutcomeIntroductionClinical Outcome StudiesPatient Cohort StudiesDefinitions of Clinical OutcomeNewcastle Patient Cohort StudiesPatient Follow UpPrediction of Clinical OutcomeSummaryReferences9. Malignant Transformation and Oral Cancer DevelopmentIntroductionThe Risk of Progression to Oral CarcinomaMalignant Transformation versus Oral Cancer DevelopmentInterventional Laser Surgery and Oral Cancer PreventionThe Newcastle 10 Year Follow Up StudyHigh and Low Risk PatientsClinical Signs of Oral Squamous Cell CarcinomaDiagnosis and Management of ‘Unexpected Malignancy’Prognosis for the ‘Transformed Patient’SummaryReferences10. The FutureIntroductionPrevention of Oral PrecancerEarly Diagnosis of Potentially Malignant DiseaseInterventional Management Strategies in the FutureIndividualised Patient Treatments – Biomarkers and Targeted ChemopreventionFuture Research DirectionsSummaryReferences11. Case HistoriesIntroductionDiagnosis of Unexpected MalignancyMultiple Lesion Disease Responding to Conservative ManagementMultiple Lesion Disease Requiring Repeated Laser TreatmentsProliferative Verrucous LeukoplakiaLocalised Oral Lichenoid ReactionMultiple Oral Lichenoid ReactionsWidespread Dysplastic Oral Lichenoid ReactionsAn Immunosuppressed PatientChronic Hyperplastic CandidosisTobacco Associated HyperkeratosisMalignant Transformation in Longstanding Non-erosive Lichen PlanusSummary12. ConclusionsOral Cancer Potentially Malignant DisordersClinical ManagementPatient Care PathwaysPublic Health StrategiesFuture DirectionsIndex

Peter Thomson is Professor of Oral and Maxillofacial Surgery at Newcastle University and Honorary Consultant in Oral and Maxillofacial Surgery at Newcastle upon Tyne Hospitals NHS Foundation Trust. In recognition of his research into oral cancer & precancer, he has been awarded both a Hunterian Professorship from the Royal College of Surgeons of England & a King James IV Professorship from the Royal College of Surgeons in Edinburgh.

“I would highly recommend the book for those wishing to expand their knowledge on oral malignancy at a specialist trainee or higher level.”  (British Dental Journal, 12 October 2013)

• List of Contributors PrefaceAcknowledgements1. IntroductionGeneral IntroductionEpidemiologyPrevention Treatment StrategiesTerminologySummaryReferences2. Structure and Function of Oral MucosaIntroductionApplied Anatomy of the Oral CavityFunction of the Oral MucosaThe Microanatomy of Oral MucosaRegional Variation of Oral MucosaOral Epithelial Cell KineticsOral Epithelial Cell Proliferative ActivityAnatomical Site Predilection for Oral CarcinogenesisSummaryReferences3. Oral CarcinogenesisIntroductionOral Cancer and PrecancerThe ‘Progression Model’ for Oral CancerAetiology and Risk FactorsPatient and Risk Factor ProfilingSummaryReferences4. Clinical Presentation of Oral PrecancerIntroductionClinical TerminologyPrecancerous (Premalignant) LesionsPrecancerous (Premalignant) ConditionsMultiple Lesion DiseaseSummaryReferences5. Diagnostic MethodsIntroductionScreeningClinical Examination TechniquesVital Tissue StainingLight Based Detection SystemsBrush Biopsy and Exfoliative CytologyClinical Diagnosis in PracticeSummaryReferences6. Pathological Aspects of Oral PrecancerIntroductionBiopsy TechniquesThe Role of the PathologistHistopathological Features of Oral Potentially Malignant DisordersGrading of DysplasiaLimitations in Conventional Pathological TechniquesSummaryReferences7. Management of Oral PrecancerIntroductionRisk Factor ModificationObservation versus InterventionMedical TreatmentSurgical TreatmentInterventional Laser SurgeryCombined Treatment ModalitiesPatient Follow Up and SurveillanceSummaryReferences8. Clinical OutcomeIntroductionClinical Outcome StudiesPatient Cohort StudiesDefinitions of Clinical OutcomeNewcastle Patient Cohort StudiesPatient Follow UpPrediction of Clinical OutcomeSummaryReferences9. Malignant Transformation and Oral Cancer DevelopmentIntroductionThe Risk of Progression to Oral CarcinomaMalignant Transformation versus Oral Cancer DevelopmentInterventional Laser Surgery and Oral Cancer PreventionThe Newcastle 10 Year Follow Up StudyHigh and Low Risk PatientsClinical Signs of Oral Squamous Cell CarcinomaDiagnosis and Management of ‘Unexpected Malignancy’Prognosis for the ‘Transformed Patient’SummaryReferences10. The FutureIntroductionPrevention of Oral PrecancerEarly Diagnosis of Potentially Malignant DiseaseInterventional Management Strategies in the FutureIndividualised Patient Treatments – Biomarkers and Targeted ChemopreventionFuture Research DirectionsSummaryReferences11. Case HistoriesIntroductionDiagnosis of Unexpected MalignancyMultiple Lesion Disease Responding to Conservative ManagementMultiple Lesion Disease Requiring Repeated Laser TreatmentsProliferative Verrucous LeukoplakiaLocalised Oral Lichenoid ReactionMultiple Oral Lichenoid ReactionsWidespread Dysplastic Oral Lichenoid ReactionsAn Immunosuppressed PatientChronic Hyperplastic CandidosisTobacco Associated HyperkeratosisMalignant Transformation in Longstanding Non-erosive Lichen PlanusSummary12. ConclusionsOral Cancer Potentially Malignant DisordersClinical ManagementPatient Care PathwaysPublic Health StrategiesFuture DirectionsIndex