Metabolic Syndrome

Edited by Christopher D. Byrne, FRCP, FRCPath, PhD, Institute for Developmental Sciences, Southampton General Hospital, Southampton, UK Sarah H. Wild, FRCPE, FFPH, PhD, Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK

"It's rare to find an academic book as engaging as this one. While clearly focused on a specific disease entity, the magnitude of the metabolic disease epidemic coupled with the comprehensive review of the topic this book delivers, should make it interesting reading to a diverse audience." (Doody's, 3 February 2012) "This excellent book must be considered the flagship text in the Wiley series encompassing obesity, diabetes and insulin resistance." (Practical Diabetes, 2011)"In all, the text provides a valuable summary of current knowledge, and it may even convince doubters of the existence of the metabolic syndrome! The information that is provided will be of considerable interest to both applied scientists and clinicians who study and treat the epidemics of physical inactivity and obesity that currently afflict so many countries." (Faculty of Physical Education & Health, 2011)

• List of Contributors viiForeword, Professor Sir George Alberti xiPreface xiii1 The Epidemiology of the Metabolic Syndrome and its Association with Diabetes, Cardiovascular Disease and Other Conditions 1Sarah H. Wild and Christopher D. Byrne2 Metabolic Syndrome and Ethnicity 19Therese Tillin and Nita G. Forouhi3 Developmental Origins of Endothelial Dysfunction: a Key Step in Cardiometabolic Disease 45Christopher Torrens, Geraldine F. Clough and Mark A. Hanson4 Developmental Origins of Insulin Resistance and Type 2 Diabetes 60Susan E. Ozanne and Kenneth Siddle5 The Metabolic Syndrome in Childhood 81Ram Weiss and Sonia Caprio6 Assessment of Insulin Sensitivity 88Julia Szendroedi, Esther Phielix and Michael Roden7 Recent Progress in Identifying Genes Contributing to Type 2 Diabetes and Metabolic Syndrome 106Weijia Xie, Timothy M. Frayling and Michael N. Weedon8 Endocrine Aspects of the Metabolic Syndrome 120Richard I.G. Holt and Peter H. Sönksen9 Brain Insulin Resistance 139Katharine F. Hunt, Yee Seun Cheah and Stephanie A. Amiel10 Cardiorespiratory Fitness and the Metabolic Syndrome 165Paul A. McAuley and Steven N. Blair11 Metabolic Syndrome and Mental Illness 177Richard I.G. Holt and Robert C. Peveler12 Atherothrombosis and the Metabolic Syndrome 194Kristina F. Standeven and Peter J. Grant13 Inflammation and Metabolic Syndrome 210Sridevi Devaraj, David Siegel and Ishwarlal Jialal14 Adipocytokine Dysregulation, Obesity and the Metabolic Syndrome 229Ulf Smith and Xiaolin Yang15 Non-Alcoholic Fatty Liver Disease 245Mohamed H. Ahmed and Christopher D. Byrne16 Polycystic Ovary Syndrome 278Naveed Sattar17 Nutrition: Its Relevance in Development and Treatment of the Metabolic Syndrome 297Lisa Te Morenga and Jim Mann18 Treatments for the Metabolic Syndrome 327Markolf Hanefeld, Ulrike Schatz and Frank Schaper19 Metabolic/Bariatric Surgery Therapy for the Metabolic Syndrome 347Henry BuchwaldIndex 357