Sande's HIV/AIDS Medicine

"In addition to the most important aspects of HIV infection, the book also covers global epidemiology, a real plus. Readers will be delighted with chapters on the biology of the virus, HIV prevention, antiretroviral therapy, and antiretroviral pharmacology. Much of the book is devoted to chapters on diseases associated with HIV infection. Special chapters detail management of mother-to-child transmission, adolescents, substance abuse, and travel medicine in the setting of HIV infection. This book is published in both print and electronic formats. The editors note that it is offered in a version for more resource-rich settings and in an overlapping but distinct version for "the resource-constrained 'South.There is no other book available that provides such an amount of detail in a compendium format. It is an excellent resource that will satisfy most readers." - Uriel Sandkovsky, MD, FACP(University of Nebraska Medical Center) Doody 4 stars"This is a comprehensive resource for infectious diseases physicians working in the developed and developing world. It's authored by a veritable 'who's who of global expertise' - the chapters stand out as they are written by real experts." - BMA Book Awards 2008 - Commended

• ContentsPreface viiContributors ixAcknowledgments xvSECTION 1: Epidemiology and biology of HIV infection1 The global epidemiology of HIV/AIDS 3Irum Zaidi, Kevin M De Cock2 The origins and diversification of HIV 15Michael Worobey, Guan-Zhu Han3 Molecular biology of HIV: implications for new therapies 25Warner C Greene, B Matija Peterlin, Matthew H Stremlau4 The immune response to HIV 45Clive M Gray, Pamela Gumbi, Lycias Zembe, Mopo Radebe, Bruce Walker5 Viral and host determinants of HIV-1 disease progression 59Danie¨lle van Manen, Ange´lique B van 't Wout, Hanneke Schuitemaker6 Acute HIV infection 77Anthony D Kelleher, David A Cooper7 Biology of HIV-1 transmission 89Julie OverbaughSECTION 2: Prevention, diagnosis, and treatment of HIV infection8 The design of a global HIV vaccine 97Jerome H Kim, Nelson L Michael9 HIV prevention 113Salim S Abdool Karim10 Laboratory testing for HIV infection 123James C Shepherd, Oliver Laeyendecker, Thomas C Quinn11 Overview of antiretroviral therapy 133Susa Coffey, Paul A Volberding12 Development and transmission of HIV drug resistance 155Mark A Wainberg, Gerasimos J Zaharatos13 Pharmacology of antiretroviral drugs 169Concepta Merry, Charles W Flexner14 Complications resulting from antiretroviral therapy for HIV infection 177David Nolan, Simon Mallal, Peter ReissSECTION 3: Diseases associated with HIV infection15 Oral complications of HIV infection 195John S Greenspan, Deborah Greenspan16 Ocular manifestations of AIDS 207James P Dunn17 Global HIV and dermatology 219Toby Maurer, Robert Michelleti18 Gastrointestinal disorders in HIV including diarrhea 237Marie-Louise C Vachon, Douglas T Dieterich19 Primary neurological manifestation of HIV/AIDS 249David B Clifford, Mengesha A Teshome20 Psychiatric barriers and the international AIDS epidemic 257Chiadi U Onyike, Andrew F Angelino,Glenn J Treisman21 Cardiovascular complications of HIV infection 267Rakesh K Mishra22 Endocrine complications of HIV infection 275Steven A Taylor, Carl Grunfeld,Morris Schambelan23 Renal complications of HIV infection 287Jula K Inrig, Lynda A Szczech,Trevor E Gerntholtz, Paul E Klotman24 Pneumocystis pneumonia 297Robert J Blount, J Lucian Davis,Laurence Huang25 Other HIV-related pneumonias 313John G Bartlett26 HIV-associated tuberculosis 325Leyla Azis, Edward C Jones-Lo´pez,Jerrold J Ellner27 Disseminated Mycobacterium avium complex and other atypical mycobacterial infections 349Mark A Jacobson28 Candida in HIV infection 359William G Powderly29 Cryptococcosis and other fungal infections(histoplasmosis and coccidioidomycosis)in HIV-infected patients 369Kathleen R Page, Richard E Chaisson,Merle Sande30 Infection due to Penicillium marneffei 389Thira Sirisanthana, Khuanchai Supparatpinyo31 AIDS-associated toxoplasmosis 397Pablo A Moncada, Jose G Montoya32 Hepatitis virus infections 411Marion G Peters, Monika Sarkar33 Bartonella infections in HIV-infected individuals 421Jane E Koehler34 Management of herpesvirus infections(cytomegalovirus, herpes simplex virus, and varicella-zoster virus) 433W Lawrence Drew, Kim S Erlich35 HIV-associated malignancies 455Ronald T Mitsuyasu36 STDs and syphilis 467Elysia Larson, Jeffrey D KlausnerSECTION 4: Prevention and management37 Prevention of mother-to-child transmission of HIV-1 485Lynne M Mofenson38 Managing HIV infection in children and adolescents 509Elizabeth H Doby, Andrew T Pavia39 Special issues regarding women with HIV infection 521Ruth M Greenblatt, Monica Gandhi40 HIV disease among substance users:treatment issues 537R Douglas Bruce, Frederick L Altice,Gerald Friedland41 The HIV-infected international traveler 551Malcolm JohnIndex 561