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Beskrivning
Over two centuries ago, oxygen was discovered as "air vital": the component of the earth's atmosphere necessary for life. The deleterious ef fects of oxygen radicals and activated oxygen species on a variety of biological systems have now been described.
1. The Biology of Oxygen Radicals: Threats and Defenses.- 2. Biological Systems Which Suppress Lipid Peroxidatio.- 3. Contrasting Features of Peroxide Metabolism in Heart and Liver.- 4. Free Radical and Iron-Mediated Injury in Lysosomes.- 5. Myocardial Effects of Partially Reduced Forms of Oxygen.- 6. Oxygen Radical Mediated Protein Oxidation in Heart.- 7. Cardiac Defense Mechanisms against Oxidative Damage: The Role of Superoxide Dismutase and Glutathione-Related Enzymes.- 8. The Role of Oxygen Free Radicals during the Course of Myocardial Ischemia/Reperfusion Injury: An Analysis and Critique.- 9. The Role of the Polymorphonuclear Leukocyte in Mediating Myocardial Reperfusion Injury.- 10. Alterations of Glutathione Status during Myocardial Ischemia and Reperfusion.- 11. Alterations in Membrane Phospholipids, Mechanisms of Free Radical Damage and Antioxidant Protection during Myocardial Ischemia and Reperfusion.- 12. The Measurement of Conjugated Dienes in Ischemic and Reperfused Myocardium.- 13. Xanthine Oxidase is not Likely to be a Source of Injurious Free Radicals in the Ischemic Human Heart: A Study of Species Differences.- 14. Role of Oxy-Radicals in Postischemic Myocardial Dysfunction.- 15. Acute Effects of Antioxidants on in Vivo Models of Experimental Myocardial Ischemia and Infarction.- 16. Do Free Radicals Contribute to the Genesis of Reperfusion-Induced Arrhythmias?.- 17. Importance of Electron Transfer through Allopurinol in Protection from Reperfusion Injury.- 18. Role of Antioxidants in Hypoxia-Reoxygenation Injury in the Heart and in Cardiac Myocytes.- 19. The Role of Lipid Peroxidation in the Myocardium in Stress and Antioxidant Protection of the Heart.- 20. Reactive Oxygen Radical Processes in Diabetes.- 21. Anthracycline-Enhanced Cardiac Oxygen Radical Metabolism.- 22. Contributions of Leukocytes to Vascular Injury and Thrombosis.