Lithium

Its Role in Psychiatric Research and Treatment

Häftad, Engelska, 2012

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Beskrivning

The introduction of the lithium ion in 1949 as a psychoactive drug preceded the advent of reserpine or chlorprom azine and placed it as the first agent in the modern era of pharmacopsy chiatry.

Produktinformation

Utgivningsdatum:2012-03-30
Mått:152 x 229 x 21 mm
Vikt:538 g
Format:Häftad
Språk:Engelska
Antal sidor:358
Förlag:Springer-Verlag New York Inc.
ISBN:9781468420241

Utforska kategorier

Psykiatri inom Medicin

Innehållsförteckning

1 A Narrative Account of Lithium Usage in Psychiatry.- I. Discovery.- II. Uses of Lithium.- III. Commercial Production of Lithium.- IV. Conclusion.- V. References.- 2 The Chemistry and Biochemistry of Lithium.- I. Introduction.- II. General Properties of Cations.- III. Chemistry of Lithium.- IV. The Biochemistry of Lithium.- V. Concluding Remarks.- VI. References.- 3 Pharmacology—Lithium Absorption, Distribution, Renal Handling, and Effect on Body Electrolytes.- I. Absorption.- II. Distribution.- III. Renal Handling.- IV. Effect on Body Electrolytes.- V. Summary.- VI. References.- 4 Pharmacology—The Effects of Lithium on Biogenic Amines.- I. Introduction.- II. Catecholamines.- III. Indoleamines.- IV. Conclusion.- V. Acknowledgments.- VI. References.- 5 Pharmacology—Lithium’s Effects on Cyclic AMP, Membrane Transport, and Cholinergic Mechanisms.- I. Cyclic AMP.- II. Membrane Transport.- III. Cholinergic Mechanisms.- IV. Acknowledgment.- V. References.- 6 Pharmacology—Neurophysiology of Lithium.- I. Introduction.- II. Microelectrode Studies.- III. Animal Studies.- IV. Human Studies.- V. Summary and Conclusions.- VI. References.- 7 Pharmacology—Toxicology of the Lithium Ion.- I. Introduction.- II. Mild-Moderate Toxic Side Effects: Minor Lithium Intolerance.- III. Lithium Poisoning.- IV. General Considerations.- V. Complications of Lithium Treatment.- VI. Other Effects of Lithium Treatment.- VII. References.- 8 Pharmacology—Lithium Teratology.- I. Introduction.- II. General Principles.- III. Studies in Premammalian Species.- IV. Studies in Mammals Other than Man.- V. Chromosome Studies.- VI. Human Studies.- VII. The Use of Lithium in Pregnancy.- VIII. Acknowledgment.- IX. References.- 9 Pharmacology—The Biology of Lithium.- I. Introduction.- II. LithiumTreatment and Electrolyte Balance.- III. Lithium Metabolism.- IV. Central Effect of Lithium.- V. Acknowledgment.- VI. References.- 10 Preparations, Dosage, and Control.- I. Preparations.- II. Initial Treatment of Mania: Dosage and Control.- III. Maintenance Treatment.- IV. References.- 11 The Affective Disorders: Clinical and Epidemiological Aspects.- I. Introduction.- II. The Classification Problem.- III. Epidemiology.- IV. Clinical Depressions.- V. Mania and Elations.- VI. Conclusions.- VII. Acknowledgment.- VIII. References.- 12 Lithium in Mania: Clinical Trials and Controlled Studies.- I. Introduction.- II. Uncontrolled and Single-Blind Studies.- III. Controlled Studies.- IV. Experimental Drugs in the Treatment of Mania.- V. Summary and Conclusions.- VI. References.- 13 Lithium and Depression.- I. Introduction.- II. Uncontrolled Studies.- III. Controlled Studies.- IV. Discussion.- V. Summary.- VI. Acknowledgment.- VII. References.- 14 Prophylactic Lithium Maintenance Treatment in Recurrent Endogenous Affective Disorders.- I. Introduction.- II. Terminology.- III. Lithium Maintenance Treatment.- IV. Remarks.- V. Acknowledgments.- VI. References.- 15 Lithium in Other Psychiatric Disorders.- I. Introduction.- II. The Use of Lithium in Schizophrenia.- III. The Use of Lithium in Neuroses and Personality Disorders without an Affective Component.- IV. The Use of Lithium in Neuroses and Personality Disorders with an Aggressive or Affective Component.- V. The Use of Lithium in Epilepsy.- VI. The Use of Lithium in Childhood Disorders.- VII. The Use of Lithium for Premenstrual Tension.- VIII. The Use of Lithium in Normals.- IX. Summary and Discussion.- X. References.- 16 Overview of Therapeutic and Prophylactic Trials with Lithium in Psychiatric Patients.- I. Introductory Analysis.- II. Confusion in Classification of the Affective Disorders: A Proposed Model for Biogenetic Investigations.- III. Therapeutic Effects in Mania.- IV. Effects in Depression.- V. Effects in Other Psychiatric Disorders.- VI. Effects on Normals, Productive Cyclothymics, and the Creative Personality.- VII. Prophylaxis.- VIII. Lithium versus Electroshock Therapy.- IX. Summary.- X. References.