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Beskrivning
In the embrace of modern molecular biology and bridging the gap between the clinical and the genomic, cardiovascular medicine has seen major strides in the understanding of the molecular mechanisms that drive disease progression.
Johann Gregor Mendel “Father of modern genetics”.- Gene therapy: hopes and problems.- VEGFs, FGFs and PDGF coordinate embryonic coronary vascularization.- The E2F pathway in cardiac development and disease.- Cardiac sodium-calcium exchanger expression.- Scleraxis: a new regulator of extracellular matrix formation.- Gender impact on pathophysiology of the heart.- Mitochondrial DNA and heart disease.- A novel algorithm from personal genome to the pathogenic mutant causing mitochondrial cardiomyopathy.- MELAS Syndrome: mediated by impaired taurinomethyluridine synthesis.- Genetics of myocardial infarction.- Genetic background of myocardial infarction.- I/D ACE polymorphism and cardiovascular risk: disclosed story.- PPARs and myocardial response to ischemia in normal and diseased heart.- Genes and plasma lipids in Czech Slavic population.- Genetic basis of salt-sensitive hypertension in humans.- Gene-environment interactions: their role in hypertension development.- Phenotypic overlap of lethal arrhythmias associated with cardiac sodium mutations: Individual-specific or mutation-specific?.- CLP-1 mediated transcriptional control of hypertrophic gene programs underlying cardiac hypertrophy.- Molecular mechanisms of subcellular remodeling in congestive heart failure.- Cardiomyopathy, sarcomeropathy and Z-discopathy.- Left ventricular assist device: morphological, molecular and genetic changes after mechanical support.- Vascular Ehlers-Danlos syndrome: a good experimental model is needed for development of treatment strategies.- Multi-scale, multi-physics heart simulator as a tool to link bench and bedside.
