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Beskrivning
This volume is a valuable and timely resource for a broad audience with interests in basic and translational cancer biology, cancer drug development, as well as in the practice of personalized oncology.
Introduction- Cancer Gene Networks.- Emerging Methods in Chemoproteomics with Relevance to Drug Discovery.- ANXA7-GTPase as Tumor Suppressor: Mechanisms and Therapeutic Opportunities.- Experimental and Study Design Considerations for Uncovering Oncometabolites.- Targeting Deubiquitinating Enzymes and Autophagy in Cancer.- Quantitative Clinical Imaging Methods for Monitoring Intratumoral Evolution.- Transcriptome and Proteome Analyses of TNFAIP8 Knockdown Cancer Cells Reveal New Insights into Molecular Determinants of Cell Survival and Tumor Progression.- Network-oriented Approaches to Anti-cancer Drug Response.- CRISPR/Cas-mediated Knockin in Human Pluripotent Stem Cells.- Complete Transcriptome RNA-Seq.- Computational Methods and Correlation of Exon-skipping Events with Splicing, Transcription and Epigenetic Factors.- Tissue Engineering Platforms to Replicate the Tumor Microenvironment of Multiple Myeloma.- microRNA Target Prediction.- Evaluating the Delivery of Proteins to the Cytosol of Mammalian Cells.- Validation of Biomarker Proteins using Reverse Capture Protein Microarrays.- Chemical Synthesis of Activity-Based Diubiquitin Probes.- Profiling the Dual Enzymatic Activities of the Serine/Threonine Kinase IRE1α.