Immunotoxicity Testing

Methods and Protocols

AvJamie C. DeWitt,Cheryl E. Rockwell

Häftad, Engelska, 2019

Del i serien Methods in Molecular Biology

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Beskrivning

This fully updated volume utilizes the expertise of scientists currently engaged in immunotoxicity testing to provide the reader with lab-ready procedures and the background information needed to identify effective testing approaches.

Produktinformation

Utgivningsdatum:2019-07-25
Mått:178 x 254 x 24 mm
Vikt:800 g
Format:Häftad
Språk:Engelska
Serie:Methods in Molecular Biology
Antal sidor:412
Upplaga:2
Förlag:Humana Press Inc.
ISBN:9781493993222

Utforska kategorier

Onkologi inom Medicin
Farmakologi inom Medicin

Innehållsförteckning

Immunotoxicology: A Brief History.- Clinical Immunotoxicology.- Investigative Immunotoxicology.- Developmental Immunotoxicity (DIT) Testing: Current Recommendations and the Future of DIT Testing.- Markers of Inflammation.- The Sheep Erythrocyte T-Dependent Antibody Response (TDAR).- Methylated-Bovine Serum Albumin (mBSA)-Induced Delayed-Type Hypersensitivity in Mice.- Use of the LLNA:BrdU-ELISA for Skin Sensitization Hazard Assessment.- Host Resistance Assays.- Enhanced Histopathology Evaluation of Lymphoid Organs.- Tumor Challenges in Immunotoxicity Testing.- Flow Cytometry for the Immunotoxicologist.- Evaluation of Cell-Mediated Immune Function Using the Cytotoxic T Lymphocyte Assay.- Evaluation of Cell Proliferation and Apoptosis in Immunotoxicity Testing.- Natural Killer (NK) Cell Assays in Immunotoxicity Testing.- Dendritic Cell Assays.- Evaluating Macrophages in Immunotoxicity Testing.- Evaluating Cytokines in Immunotoxicity Testing.- Functional Assays of Hematopoietic Stem Cellsin Toxicology Research.- CD4+ T Cell Differentiation and Activation.- Isolation and Identification of Innate Lymphoid Cells (ILCs) for Immunotoxicity Testing.- Evaluating Antigen-Specific IgE Using the Rat Basophil Leukemia Cell (RBL) Assay.- Challenges for Integrating Immunotoxicology into the 21st Century Toxicology Testing Paradigm.