C. Yan Cheng Ph.D. is a senior scientist at the Population Council’s Center for Biomedical Research, New York, affiliated with the Council's Reproductive Health program, where his research focuses on developing new male contraceptive methods through a better understanding of male fertility and infertility, and on the biology of the blood-testis barrier and the mechanism by which environmental toxicants induce testicular injury. He serves as an ad-hoc reviewer of grant proposals submitted to the National Institutes of Health’s Cellular, Molecular and Integrative Reproduction Study Section and the Endocrinology, Metabolism, Nutrition and Reproductive Sciences Study Section. He holds a Ph.D. in biochemistry and cell biology from the University of Newcastle, New South Wales, Australia, after an undergraduate degree from the Chinese University of Hong Kong. His research has been supported by the National Institute of Child Health and Human Development, National Institutes of Health, for the last three decades. He has published more than 400 peer-reviewed papers. He was awarded the Richard E. Weizman Memorial Award from the Endocrine Society in 1988 and received the Best Scientific Paper Award from the American Society of Andrology in 1997. He also served as the Editor-in-Chief of the peer-review journal Spermatogenesis from 2011 through 2016.

"This is a remarkable addition to the field of spermatogenesis, furthering ourunderstanding of meiosis and new developments in the conversion of earlyspermatocytes to haploid spermatids, a process clinically relevant to thetreatment of nonobstructive azoospermia. It uniquely addresses the contemporarychallenges of environmental spermatotoxins."Irvin H Hirsch, MD (Thomas Jefferson University)

• Preface Contributors 1. Golgi apparatus regulation of differentiation: A case study for male germ cells of the rat testis Louis Hermo, Regiana L. Oliveira, Charles E. Smith, Catherine E. Au, and John J. M. Bergeron2. Androgen regulation of spermatogenesis William H. Walker3. Testicular immunoregulation: The role of Tyro3, Axl, and Mer receptor tyrosine kinases and pattern recognition receptors Fei Wang, Qian Jiang, and Daishu Han4. Inflammation and Spermatogenesis Maria Susana Theas, Patricia Verónica Jacobo, Cecilia Valeria Pérez, Vanesa Anabella Guazzone, and Livia Lustig5. Junctional adhesion molecule (JAM) family: Recent findings and their role and regulation in spermatogenesis Kun Huang and Wing-Yee Lui6. Sertoli cell immune regulation within the testis Gurvinder Kaur, Kandis Wright, Robin Hannah Greer, Karl Mueller, Allan Haynes, and Jannette M. Dufour7. The mitotic phase of spermatogenesis: Recent advances and perspectives Kin Lam Fok and Hsiao Chang Chan8. Genetics of mammalian meiosis Fang Yang and P. Jeremy Wang9. Roles of membrane and nuclear estrogen receptors in spermatogenesis Paul S. Cooke, Manjunatha K. Nanjappa, Sergei G. Tevosian, and Rex A. Hess10. Regulation of fertility and infertility in humans Nahid Punjani, Ryan Flannigan, and Peter N. Schlegel11. Male infertility: Evaluation and treatment Ryan Flannigan and Marc Goldstein12. Effects of chemical pollutants on spermatogenesis and implications in male infertility Chris KC Wong13. Advances in our understanding of human spermatogenesis Qing Wen, Elizabeth I. Tang, Tito Jesus, Bruno Silvestrini, and C. Yan Cheng14. A look into the testis as a reservoir for HIV and ZIKV—A reproductive biologist’s perspective Elizabeth I. Tang, Christopher L. Robinson, Chi Nok Chong, Shuibing Chen, and C. Yan Cheng15. Cytoskeletons (F-actin) and spermatogenesis Liza O’Donnell and Peter G. Stanton16. Roles of mTOR signaling in spermatogenesis Lan Ye and Ke Zheng17. Does planar cell polarity matter during spermatogenesis? Linxi Li, Haiqi Chen, Qingquan Lian, Ren-Shan Ge, and C. Yan Cheng18. Computational characterization and integrative analysis of proteins involved in Spermatogenesis Pranitha Jenardhanan, Manivel Panneerselvam, and Premendu P. Mathur19. Effects of chemical exposures on testis cell-cell interactions and endocrine function Rachel C. Knight, Jennifer R. Panizzi, and Benson T. Akingbemi20. Environmental toxicants on Leydig cell function Leping Ye, Xiaoheng Li, Xiaomin Chen, Qingquan Lian, and Ren-Shan GeIndex

C. Yan Cheng Ph.D. is a senior scientist at the Population Council’s Center for Biomedical Research, New York, affiliated with the Council's Reproductive Health program, where his research focuses on developing new male contraceptive methods through a better understanding of male fertility and infertility, and on the biology of the blood-testis barrier and the mechanism by which environmental toxicants induce testicular injury. He serves as an ad-hoc reviewer of grant proposals submitted to the National Institutes of Health’s Cellular, Molecular and Integrative Reproduction Study Section and the Endocrinology, Metabolism, Nutrition and Reproductive Sciences Study Section. He holds a Ph.D. in biochemistry and cell biology from the University of Newcastle, New South Wales, Australia, after an undergraduate degree from the Chinese University of Hong Kong. His research has been supported by the National Institute of Child Health and Human Development, National Institutes of Health, for the last three decades. He has published more than 400 peer-reviewed papers. He was awarded the Richard E. Weizman Memorial Award from the Endocrine Society in 1988 and received the Best Scientific Paper Award from the American Society of Andrology in 1997. He also served as the Editor-in-Chief of the peer-review journal Spermatogenesis from 2011 through 2016.

"This is a remarkable addition to the field of spermatogenesis, furthering ourunderstanding of meiosis and new developments in the conversion of earlyspermatocytes to haploid spermatids, a process clinically relevant to thetreatment of nonobstructive azoospermia. It uniquely addresses the contemporarychallenges of environmental spermatotoxins."Irvin H Hirsch, MD (Thomas Jefferson University)

• Preface Contributors 1. Golgi apparatus regulation of differentiation: A case study for male germ cells of the rat testis Louis Hermo, Regiana L. Oliveira, Charles E. Smith, Catherine E. Au, and John J. M. Bergeron2. Androgen regulation of spermatogenesis William H. Walker3. Testicular immunoregulation: The role of Tyro3, Axl, and Mer receptor tyrosine kinases and pattern recognition receptors Fei Wang, Qian Jiang, and Daishu Han4. Inflammation and Spermatogenesis Maria Susana Theas, Patricia Verónica Jacobo, Cecilia Valeria Pérez, Vanesa Anabella Guazzone, and Livia Lustig5. Junctional adhesion molecule (JAM) family: Recent findings and their role and regulation in spermatogenesis Kun Huang and Wing-Yee Lui6. Sertoli cell immune regulation within the testis Gurvinder Kaur, Kandis Wright, Robin Hannah Greer, Karl Mueller, Allan Haynes, and Jannette M. Dufour7. The mitotic phase of spermatogenesis: Recent advances and perspectives Kin Lam Fok and Hsiao Chang Chan8. Genetics of mammalian meiosis Fang Yang and P. Jeremy Wang9. Roles of membrane and nuclear estrogen receptors in spermatogenesis Paul S. Cooke, Manjunatha K. Nanjappa, Sergei G. Tevosian, and Rex A. Hess10. Regulation of fertility and infertility in humans Nahid Punjani, Ryan Flannigan, and Peter N. Schlegel11. Male infertility: Evaluation and treatment Ryan Flannigan and Marc Goldstein12. Effects of chemical pollutants on spermatogenesis and implications in male infertility Chris KC Wong13. Advances in our understanding of human spermatogenesis Qing Wen, Elizabeth I. Tang, Tito Jesus, Bruno Silvestrini, and C. Yan Cheng14. A look into the testis as a reservoir for HIV and ZIKV—A reproductive biologist’s perspective Elizabeth I. Tang, Christopher L. Robinson, Chi Nok Chong, Shuibing Chen, and C. Yan Cheng15. Cytoskeletons (F-actin) and spermatogenesis Liza O’Donnell and Peter G. Stanton16. Roles of mTOR signaling in spermatogenesis Lan Ye and Ke Zheng17. Does planar cell polarity matter during spermatogenesis? Linxi Li, Haiqi Chen, Qingquan Lian, Ren-Shan Ge, and C. Yan Cheng18. Computational characterization and integrative analysis of proteins involved in Spermatogenesis Pranitha Jenardhanan, Manivel Panneerselvam, and Premendu P. Mathur19. Effects of chemical exposures on testis cell-cell interactions and endocrine function Rachel C. Knight, Jennifer R. Panizzi, and Benson T. Akingbemi20. Environmental toxicants on Leydig cell function Leping Ye, Xiaoheng Li, Xiaomin Chen, Qingquan Lian, and Ren-Shan GeIndex

C. Yan Cheng Ph.D. is a senior scientist at the Population Council’s Center for Biomedical Research, New York, affiliated with the Council's Reproductive Health program, where his research focuses on developing new male contraceptive methods through a better understanding of male fertility and infertility, and on the biology of the blood-testis barrier and the mechanism by which environmental toxicants induce testicular injury. He serves as an ad-hoc reviewer of grant proposals submitted to the National Institutes of Health’s Cellular, Molecular and Integrative Reproduction Study Section and the Endocrinology, Metabolism, Nutrition and Reproductive Sciences Study Section. He holds a Ph.D. in biochemistry and cell biology from the University of Newcastle, New South Wales, Australia, after an undergraduate degree from the Chinese University of Hong Kong. His research has been supported by the National Institute of Child Health and Human Development, National Institutes of Health, for the last three decades. He has published more than 400 peer-reviewed papers. He was awarded the Richard E. Weizman Memorial Award from the Endocrine Society in 1988 and received the Best Scientific Paper Award from the American Society of Andrology in 1997. He also served as the Editor-in-Chief of the peer-review journal Spermatogenesis from 2011 through 2016.

"This is a remarkable addition to the field of spermatogenesis, furthering ourunderstanding of meiosis and new developments in the conversion of earlyspermatocytes to haploid spermatids, a process clinically relevant to thetreatment of nonobstructive azoospermia. It uniquely addresses the contemporarychallenges of environmental spermatotoxins."Irvin H Hirsch, MD (Thomas Jefferson University)

• Preface Contributors 1. Golgi apparatus regulation of differentiation: A case study for male germ cells of the rat testis Louis Hermo, Regiana L. Oliveira, Charles E. Smith, Catherine E. Au, and John J. M. Bergeron2. Androgen regulation of spermatogenesis William H. Walker3. Testicular immunoregulation: The role of Tyro3, Axl, and Mer receptor tyrosine kinases and pattern recognition receptors Fei Wang, Qian Jiang, and Daishu Han4. Inflammation and Spermatogenesis Maria Susana Theas, Patricia Verónica Jacobo, Cecilia Valeria Pérez, Vanesa Anabella Guazzone, and Livia Lustig5. Junctional adhesion molecule (JAM) family: Recent findings and their role and regulation in spermatogenesis Kun Huang and Wing-Yee Lui6. Sertoli cell immune regulation within the testis Gurvinder Kaur, Kandis Wright, Robin Hannah Greer, Karl Mueller, Allan Haynes, and Jannette M. Dufour7. The mitotic phase of spermatogenesis: Recent advances and perspectives Kin Lam Fok and Hsiao Chang Chan8. Genetics of mammalian meiosis Fang Yang and P. Jeremy Wang9. Roles of membrane and nuclear estrogen receptors in spermatogenesis Paul S. Cooke, Manjunatha K. Nanjappa, Sergei G. Tevosian, and Rex A. Hess10. Regulation of fertility and infertility in humans Nahid Punjani, Ryan Flannigan, and Peter N. Schlegel11. Male infertility: Evaluation and treatment Ryan Flannigan and Marc Goldstein12. Effects of chemical pollutants on spermatogenesis and implications in male infertility Chris KC Wong13. Advances in our understanding of human spermatogenesis Qing Wen, Elizabeth I. Tang, Tito Jesus, Bruno Silvestrini, and C. Yan Cheng14. A look into the testis as a reservoir for HIV and ZIKV—A reproductive biologist’s perspective Elizabeth I. Tang, Christopher L. Robinson, Chi Nok Chong, Shuibing Chen, and C. Yan Cheng15. Cytoskeletons (F-actin) and spermatogenesis Liza O’Donnell and Peter G. Stanton16. Roles of mTOR signaling in spermatogenesis Lan Ye and Ke Zheng17. Does planar cell polarity matter during spermatogenesis? Linxi Li, Haiqi Chen, Qingquan Lian, Ren-Shan Ge, and C. Yan Cheng18. Computational characterization and integrative analysis of proteins involved in Spermatogenesis Pranitha Jenardhanan, Manivel Panneerselvam, and Premendu P. Mathur19. Effects of chemical exposures on testis cell-cell interactions and endocrine function Rachel C. Knight, Jennifer R. Panizzi, and Benson T. Akingbemi20. Environmental toxicants on Leydig cell function Leping Ye, Xiaoheng Li, Xiaomin Chen, Qingquan Lian, and Ren-Shan GeIndex