Noel R. Rose, MD, PhD, Professor of Pathology and of Molecular Microbiology and Immunology; Director, Center for Autoimmune Disease Research, The Johns Hopkins University

• The proper study: preface to The Year in Immunology vNoel R. RoseThe long pentraxin PTX3: a paradigm for humoral pattern recognition molecules 1Alberto Mantovani, Sonia Valentino, Stefania Gentile, Antonio Inforzato, Barbara Bottazzi, and Cecilia GarlandaThe role of autoimmunity in thromboangiitis obliterans (Buerger’s disease) 15Siva S. Ketha and Leslie T. CooperWiskott-Aldrich syndrome: a comprehensive review 26Michel J. Massaad, Narayanaswamy Ramesh, and Raif S. GehaAnti-β₂-glcoprotein I antibodies 44Rohan Willis and Silvia S. PierangeliGetting away with murder: how does the BCL-2 family of proteins kill with immunity? 59Thibaud T. Ranault and Jerry E. ChipukControl of inflammatory heart disease by CD4+ T cells 80Jobert G. Barin and Daniela ČihákováHuman B-1 cells take the stage 97Thomas L. Rothstein, Daniel O. Griffin, Nichol E. Holodick, Tam D. Quach, and Hiroaki KakuReverse vaccinology in the 21st century: improvements over the original design 115Claudio Donati and Rino RappuoliThe National Institutes of Health Center for Human Immunology, Autoimmunity, and Inflammation: history and progress 133Howard B. Dickler, J. Philip McCoy, Robert Nussenblatt, Shira Perl, Pamela A. Schwartzberg, John S. Tsang, Ena Wang, and Neil S. Young