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Beskrivning
The G Protein-Coupled Receptors handbook provides a comprehensive overview of recent advances in the G protein-coupled receptor (GPCR) field. This volume reviews the recent advances and current knowledge regarding GPCR's from the basics of GPCR structure to dimerization and drug discovery.
"...provides an excellent resource to introduce the reader to many of the diverse areas and questions that drive research in the GCPR field." -TRENDS in Endocrinology and Metablosim
Innehållsförteckning
GPCRs: Structure and Function.- Structure—Function Relationships in G Protein-Coupled Receptors.- Molecular Mechanisms Involved in the Activation of Rhodopsin-Like Seven-Transmembrane Receptors.- GPCR Folding and Maturation.- Regulated Membrane Trafficking and Proteolysis of GPCRs.- GPCR Activity and Its Regulators.- Heterotrimeric G Proteins and Their Effector Pathways.- RGS Proteins.- G Protein-Coupled Receptor Kinases.- Regulators of GPCR Activity.- GPCR Interacting Proteins.- GPCR Dimerization/Oligomerization.- Biophysical and Biochemical Methods to Study GPCR Oligomerization.- Oligomerization Domains of G Protein-Coupled Receptors.- Functional Complementation and the Analysis of GPCR Dimerization.- The Role of Oligomerization in G Protein-Coupled Receptor Maturation.- Receptor Oligomerization and Trafficking.- Modulation of Receptor Pharmacology by G Protein-Coupled Receptor Dimerization.- Recent Developments in Drug Discovery.- Role of Heteromeric GPCR Interactions in Pain/Analgesia.- Conformational Plasticity of GPCR Binding Sites.- De-Orphanizing GPCRs and Drug Development.
